MEP0208A - Aptameri koji vezuje trombin sa visokim afininitetom - Google Patents

Aptameri koji vezuje trombin sa visokim afininitetom

Info

Publication number
MEP0208A
MEP0208A MEP-02/08A MEP0208A MEP0208A ME P0208 A MEP0208 A ME P0208A ME P0208 A MEP0208 A ME P0208A ME P0208 A MEP0208 A ME P0208A
Authority
ME
Montenegro
Prior art keywords
aptamers
thrombin
high affinity
bind thrombin
binding
Prior art date
Application number
MEP-02/08A
Other languages
English (en)
Inventor
John L Diener
Jess Wagner-Whyte
David Fontana
Original Assignee
Archemix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archemix Corp filed Critical Archemix Corp
Publication of MEP0208A publication Critical patent/MEP0208A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

Abstract

Pronalazak obezbjeđuje aptamere koji mogu da vežu trobmin, a koji su korisni kao terapeutici za i dojagnostici poremećaja povezanih sa koaguacijom i/ili drugih bolesti gdje je uključen trombin. Pronalazak dalje obezbjeđuje materijale i postupke za administraciju aptamera koji je sposoban da se veže za trombin.
MEP-02/08A 2005-08-26 2006-08-23 Aptameri koji vezuje trombin sa visokim afininitetom MEP0208A (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71176805P 2005-08-26 2005-08-26
US80859006P 2006-05-26 2006-05-26
PCT/US2006/033092 WO2007025049A2 (en) 2005-08-26 2006-08-23 Aptamers that bind thrombin with high affinity

Publications (1)

Publication Number Publication Date
MEP0208A true MEP0208A (xx) 2010-02-10

Family

ID=37772390

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-02/08A MEP0208A (xx) 2005-08-26 2006-08-23 Aptameri koji vezuje trombin sa visokim afininitetom
MEP-2008-2A ME00016B (me) 2005-08-26 2006-08-23 Aptameri koji vezuje trombin sa visokim afininitetom

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-2A ME00016B (me) 2005-08-26 2006-08-23 Aptameri koji vezuje trombin sa visokim afininitetom

Country Status (12)

Country Link
US (2) US7998939B2 (bs)
EP (1) EP1928505A4 (bs)
JP (1) JP2009508473A (bs)
KR (1) KR20080042091A (bs)
AU (1) AU2006283025A1 (bs)
BR (1) BRPI0614961A2 (bs)
CA (1) CA2617782A1 (bs)
EA (1) EA200800667A1 (bs)
IL (1) IL188797A0 (bs)
ME (2) MEP0208A (bs)
RS (1) RS20080075A (bs)
WO (1) WO2007025049A2 (bs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008134069A2 (en) * 2007-04-26 2008-11-06 University Of Florida Research Foundation Anchored ligand agents
WO2009149921A2 (en) * 2008-06-11 2009-12-17 Bionucleon S.R.L. Inhibition of hrp-3 using modified oligonucleotides
US20110275701A1 (en) * 2008-09-18 2011-11-10 Archemix Corp. Anti-thrombin aptamer formulations and methods for use
EP2497828A1 (en) * 2011-03-07 2012-09-12 Charité - Universitätsmedizin Berlin Use of aptamers in therapy and/or diagnosis of autoimmune diseases
FR2983212A1 (fr) * 2011-11-28 2013-05-31 Lfb Biotechnologies Aptameres anti-fh, procede pour leur obtention et utilisations
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
WO2014210546A1 (en) * 2013-06-27 2014-12-31 University Of Washington Through Its Center For Commercialization Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders
BR102013021701A2 (pt) 2013-08-26 2015-07-28 Univ São Paulo Usp Polinucleotídeos quimicamente modificados e processo de produção de polinucleotídeos quimicamente modificados
JP6680760B2 (ja) * 2014-07-31 2020-04-15 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ アンタゴニストｉｃ ｐｄ−１アプタマー及びその癌治療関連用途への応用
EP2982756A1 (en) * 2014-08-04 2016-02-10 Berlin Cures Holding AG Aptamers for use against autoantibody-associated diseases
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US20230012024A1 (en) * 2019-12-04 2023-01-12 Duke University Methods for controlling extracorporeal membrane oxygenation (ecmo) coagulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920561A1 (en) 1991-02-21 1992-08-26 Gilead Sciences Aptamer specific for thrombin and methods of use
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
JPH10510540A (ja) * 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US20030054360A1 (en) 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
EP1481090A4 (en) * 2002-02-15 2006-08-09 Somalogic Inc METHOD AND REAGENTS FOR DETECTING BINDING OF TARGET MOLECULES BY NUCLEIC ACID ELECTRODES
US20050037394A1 (en) 2002-12-03 2005-02-17 Keefe Anthony D. Method for in vitro selection of 2'-substituted nucleic acids
WO2004050899A2 (en) 2002-12-03 2004-06-17 Archemix Corporation Method for in vitro selection of 2’-substituted nucleic acids
JP2007525661A (ja) * 2003-12-12 2007-09-06 セントルイス ユニバーシティー 大分子その他の分析物の検出用生物センサー
EP1942911A4 (en) 2005-09-29 2009-08-19 Replicor Inc THERAPEUTIC MOLECULES AND USES THEREOF
US7807648B2 (en) 2005-10-06 2010-10-05 University Of Delaware G-rich polynucleotides for the treatment of Huntington's Disease

Also Published As

Publication number Publication date
US20120149764A1 (en) 2012-06-14
JP2009508473A (ja) 2009-03-05
EP1928505A2 (en) 2008-06-11
KR20080042091A (ko) 2008-05-14
RS20080075A (en) 2009-07-15
AU2006283025A1 (en) 2007-03-01
IL188797A0 (en) 2008-08-07
US7998939B2 (en) 2011-08-16
EP1928505A4 (en) 2010-10-27
WO2007025049A2 (en) 2007-03-01
US20090221680A1 (en) 2009-09-03
ME00016B (me) 2010-06-10
CA2617782A1 (en) 2007-03-01
BRPI0614961A2 (pt) 2016-09-13
EA200800667A1 (ru) 2008-08-29
WO2007025049A3 (en) 2009-04-16

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