MD960288A - Metodă de separare a formelor DNazei, DNaza omului, compoziţie farmaceutică, metodă de păstrare a DNazei, metodă de tratare - Google Patents
Metodă de separare a formelor DNazei, DNaza omului, compoziţie farmaceutică, metodă de păstrare a DNazei, metodă de tratareInfo
- Publication number
- MD960288A MD960288A MD96-0288A MD960288A MD960288A MD 960288 A MD960288 A MD 960288A MD 960288 A MD960288 A MD 960288A MD 960288 A MD960288 A MD 960288A
- Authority
- MD
- Moldova
- Prior art keywords
- dnase
- separating
- pharmaceutical composition
- forms
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
- C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Prezenta invenţie se referă la identificarea şi caracterizarea a două componente ale preparatului DNazei recombinante. Aceste componente reprezintă DNaza umană purificată dezaminată şi DNaza umană purificată nedezaminată. În prezenta invenţie sunt studiate metodele de separare a acestor componente şi utilizarea în scopuri farmaceutice a formei nedezaminate, în special în componenţa compoziţiilor, atunci când formele sunt situate în fiole de masă plastică, pentru administrare pacienţilor care suferă de dereglări cu caracter pulmonar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/895,300 US5279823A (en) | 1992-06-08 | 1992-06-08 | Purified forms of DNASE |
PCT/US1993/005136 WO1993025670A1 (en) | 1992-06-08 | 1993-05-28 | Purified forms of dnase |
Publications (1)
Publication Number | Publication Date |
---|---|
MD960288A true MD960288A (ro) | 1998-01-31 |
Family
ID=25404292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD96-0288A MD960288A (ro) | 1992-06-08 | 1993-05-28 | Metodă de separare a formelor DNazei, DNaza omului, compoziţie farmaceutică, metodă de păstrare a DNazei, metodă de tratare |
Country Status (30)
Country | Link |
---|---|
US (4) | US5279823A (ro) |
EP (2) | EP0644932B1 (ro) |
JP (1) | JP3383307B2 (ro) |
KR (2) | KR100302092B1 (ro) |
AT (2) | ATE195340T1 (ro) |
AU (1) | AU682822B2 (ro) |
BG (1) | BG62335B1 (ro) |
BR (1) | BR9306670A (ro) |
CA (1) | CA2137237C (ro) |
CZ (1) | CZ293105B6 (ro) |
DE (3) | DE69334317D1 (ro) |
DK (1) | DK0644932T3 (ro) |
ES (1) | ES2150447T3 (ro) |
FI (1) | FI945549A (ro) |
GB (1) | GB2282140B (ro) |
GE (1) | GEP20002300B (ro) |
GR (1) | GR3034718T3 (ro) |
HU (1) | HU219549B (ro) |
IL (1) | IL105724A (ro) |
MD (1) | MD960288A (ro) |
NO (1) | NO318644B1 (ro) |
NZ (1) | NZ253559A (ro) |
PL (1) | PL175873B1 (ro) |
PT (1) | PT644932E (ro) |
RO (1) | RO117188B1 (ro) |
RU (1) | RU2238320C2 (ro) |
SK (1) | SK282957B6 (ro) |
TJ (1) | TJ396B (ro) |
UA (1) | UA46693C2 (ro) |
WO (1) | WO1993025670A1 (ro) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD20010375A (ro) * | 2001-11-19 | 2003-06-30 | АНДРИЕВСКИ Сергей | Malaxor |
MD2260C2 (ro) * | 2001-11-22 | 2004-03-31 | АНДРИЕВСКИ Сергей | Malaxor |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0853121B1 (en) * | 1988-12-23 | 2007-03-28 | Genentech, Inc. | Human DNase |
US5279823A (en) * | 1992-06-08 | 1994-01-18 | Genentech, Inc. | Purified forms of DNASE |
WO1995023613A1 (en) * | 1994-03-04 | 1995-09-08 | Genentech, Inc. | PHARMACEUTICALLY ACCEPTABLE DNase FORMULATION |
US6383788B1 (en) * | 1994-03-04 | 2002-05-07 | Genentech, Inc. | Minimizing thermally induced aggregation of DNase in solution with calcium |
US6251648B1 (en) | 1998-04-03 | 2001-06-26 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
US5830744A (en) * | 1995-06-06 | 1998-11-03 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
EP0817839A1 (en) * | 1994-05-05 | 1998-01-14 | Human Genome Sciences, Inc. | Human dnase |
US5602110A (en) * | 1994-08-31 | 1997-02-11 | Case Western Reserve University | Method and composition for treating cystic fibrosis |
US5821103A (en) * | 1994-09-06 | 1998-10-13 | Tanuma; Sei-Ichi | Deoxyribonuclease |
US5863563A (en) * | 1994-10-20 | 1999-01-26 | Alphagene Inc. | Treatment of pulmonary conditions associated with insufficient secretion of surfactant |
US6348343B2 (en) | 1995-02-24 | 2002-02-19 | Genentech, Inc. | Human DNase I variants |
SK284191B6 (sk) | 1995-02-24 | 2004-10-05 | Genentech, Inc. | Aktín-rezistentný variant humánnej DNázy I |
ATE332379T1 (de) * | 1996-02-05 | 2006-07-15 | Genentech Inc | Menschliche dnase resistent gegen actininhibitoren |
US6482626B2 (en) * | 1996-02-05 | 2002-11-19 | Genentech, Inc. | Human DNase |
US6391607B1 (en) | 1996-06-14 | 2002-05-21 | Genentech, Inc. | Human DNase I hyperactive variants |
IL139035A0 (en) * | 1998-05-06 | 2001-11-25 | Genentech Inc | Protein purification by ion exchange chromatography |
NZ521051A (en) * | 2000-02-11 | 2003-07-25 | Profile Respiratory Systems Lt | Drug delivery apparatus |
US8820316B2 (en) * | 2000-02-11 | 2014-09-02 | Respironics Respiratory Drug Delivery (Uk) Ltd | Drug delivery apparatus |
DE60135983D1 (de) * | 2000-05-31 | 2008-11-13 | Novartis Vaccines & Diagnostic | Verfahren zur reinigung von alphaviralen replikon partikeln |
ES2629602T5 (es) | 2002-09-11 | 2021-06-08 | Genentech Inc | Purificación de proteínas |
US7067298B2 (en) | 2003-03-31 | 2006-06-27 | Ambion, Inc. | Compositions and methods of using a synthetic Dnase I |
US7595179B2 (en) | 2004-04-19 | 2009-09-29 | Applied Biosystems, Llc | Recombinant reverse transcriptases |
US20080160577A1 (en) * | 2005-02-04 | 2008-07-03 | Glaxo Group Limited | Optimization of Heterologous Polypeptide Expression |
KR100655438B1 (ko) * | 2005-08-25 | 2006-12-08 | 삼성전자주식회사 | 자기 기억 소자 및 그 형성 방법 |
WO2007143206A2 (en) * | 2006-06-02 | 2007-12-13 | Epicentre Technologies | Compositions and methods for removal of dna from a sample |
PT2086642E (pt) | 2006-10-18 | 2014-09-30 | Periness Ltd | Dnase para o tratamento de subfertilidade masculina |
BRPI0817182A2 (pt) | 2007-10-30 | 2015-03-17 | Genentech Inc | Método para purificar um anticorpo e composições |
WO2009123950A2 (en) * | 2008-03-31 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Chimera comprising bacterial cytotoxin and methods of using the same |
GB2474225A (en) * | 2009-07-21 | 2011-04-13 | Biotec Pharmacon Asa | DNase for decontamination of reverse transcription and amplification reactions |
EP3318635A1 (en) | 2011-04-21 | 2018-05-09 | University of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
WO2013114371A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dry powder formulations of dnase i |
CN103920144B (zh) * | 2013-01-15 | 2016-09-14 | 吴庄民 | 重组人的脱氧核糖核酸酶i的新应用 |
RU2017101727A (ru) * | 2014-06-25 | 2018-07-25 | ДжейЭйчЭл БИОТЕК, ИНК. | Способы и реагенты для очистки белков |
EP3214172B1 (en) | 2014-10-31 | 2019-02-13 | JCR Pharmaceuticals CO., LTD. | Method for producing remcombinant human dnasei |
WO2017019876A1 (en) * | 2015-07-28 | 2017-02-02 | University Of Massachusetts | Transgenic expression of dnase i in vivo delivered by an adeno-associated virus vector |
US11060088B2 (en) | 2016-02-12 | 2021-07-13 | University Of Massachusetts | Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
MX2019005617A (es) | 2016-11-17 | 2019-08-14 | Iovance Biotherapeutics Inc | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. |
EP3351263A1 (en) | 2017-01-20 | 2018-07-25 | Universitätsklinikum Hamburg-Eppendorf | Pharmaceutical preparation for treating or preventing tissue adhesion |
WO2021244964A1 (en) | 2020-06-01 | 2021-12-09 | Black Cat Bio Limited | Compositions and methods for treating infections and netopathy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2801956A (en) * | 1954-08-24 | 1957-08-06 | Merck & Co Inc | Process for preparing pancreatic desoxyribonuclease |
US2834710A (en) * | 1955-06-29 | 1958-05-13 | Merck & Co Inc | Pancreatic desoxyribonuclease penicillin composition and process of preparation |
US3208908A (en) * | 1961-11-16 | 1965-09-28 | Parke Davis & Co | Fibrinolysin-desoxyribonuclease for enzymatic debridement |
US3663690A (en) * | 1969-08-12 | 1972-05-16 | Hoechst Co American | Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith |
CA1059937A (en) * | 1975-03-25 | 1979-08-07 | Boen T. Khouw | Isolation and purification of deoxyribonuclease |
US5077211A (en) * | 1988-07-06 | 1991-12-31 | Applied Genetics, Inc. | Purification and administration of dna repair enzymes |
EP0853121B1 (en) * | 1988-12-23 | 2007-03-28 | Genentech, Inc. | Human DNase |
US5279823A (en) * | 1992-06-08 | 1994-01-18 | Genentech, Inc. | Purified forms of DNASE |
-
1992
- 1992-06-08 US US07/895,300 patent/US5279823A/en not_active Expired - Lifetime
-
1993
- 1993-05-18 IL IL105724A patent/IL105724A/xx not_active IP Right Cessation
- 1993-05-28 AU AU43981/93A patent/AU682822B2/en not_active Expired
- 1993-05-28 SK SK1495-94A patent/SK282957B6/sk not_active IP Right Cessation
- 1993-05-28 KR KR1019940704462A patent/KR100302092B1/ko not_active IP Right Cessation
- 1993-05-28 DE DE69334317T patent/DE69334317D1/de not_active Expired - Lifetime
- 1993-05-28 NZ NZ253559A patent/NZ253559A/en not_active IP Right Cessation
- 1993-05-28 CZ CZ19943032A patent/CZ293105B6/cs not_active IP Right Cessation
- 1993-05-28 DE DE69329200T patent/DE69329200T2/de not_active Expired - Lifetime
- 1993-05-28 JP JP50152894A patent/JP3383307B2/ja not_active Expired - Lifetime
- 1993-05-28 HU HU9403512A patent/HU219549B/hu unknown
- 1993-05-28 AT AT93914258T patent/ATE195340T1/de active
- 1993-05-28 EP EP93914258A patent/EP0644932B1/en not_active Expired - Lifetime
- 1993-05-28 RO RO94-01956A patent/RO117188B1/ro unknown
- 1993-05-28 CA CA002137237A patent/CA2137237C/en not_active Expired - Lifetime
- 1993-05-28 GE GEAP19932382A patent/GEP20002300B/en unknown
- 1993-05-28 DE DE4392749T patent/DE4392749T1/de not_active Ceased
- 1993-05-28 UA UA95018026A patent/UA46693C2/uk unknown
- 1993-05-28 EP EP00101817A patent/EP1013284B1/en not_active Expired - Lifetime
- 1993-05-28 PL PL93306723A patent/PL175873B1/pl unknown
- 1993-05-28 KR KR1020017003922A patent/KR100323357B1/ko not_active IP Right Cessation
- 1993-05-28 BR BR9306670A patent/BR9306670A/pt not_active Application Discontinuation
- 1993-05-28 ES ES93914258T patent/ES2150447T3/es not_active Expired - Lifetime
- 1993-05-28 RU RU94046424A patent/RU2238320C2/ru active
- 1993-05-28 PT PT93914258T patent/PT644932E/pt unknown
- 1993-05-28 MD MD96-0288A patent/MD960288A/ro unknown
- 1993-05-28 TJ TJ96000330A patent/TJ396B/xx unknown
- 1993-05-28 WO PCT/US1993/005136 patent/WO1993025670A1/en active IP Right Grant
- 1993-05-28 GB GB9423695A patent/GB2282140B/en not_active Expired - Lifetime
- 1993-05-28 AT AT00101817T patent/ATE455557T1/de active
- 1993-05-28 DK DK93914258T patent/DK0644932T3/da active
-
1994
- 1994-11-25 FI FI945549A patent/FI945549A/fi not_active IP Right Cessation
- 1994-12-02 BG BG99234A patent/BG62335B1/bg unknown
- 1994-12-08 NO NO19944752A patent/NO318644B1/no not_active IP Right Cessation
-
1995
- 1995-06-02 US US08/458,367 patent/US5783433A/en not_active Expired - Lifetime
-
2000
- 2000-08-11 US US09/638,112 patent/US6440412B1/en not_active Expired - Fee Related
- 2000-10-30 GR GR20000402407T patent/GR3034718T3/el unknown
-
2002
- 2002-05-22 US US10/155,407 patent/US6932965B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD20010375A (ro) * | 2001-11-19 | 2003-06-30 | АНДРИЕВСКИ Сергей | Malaxor |
MD2260C2 (ro) * | 2001-11-22 | 2004-03-31 | АНДРИЕВСКИ Сергей | Malaxor |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD99 | Pending application |