MD4642C1 - Полимерный материал с антимикробной активностью в отношении Proteus vulgaris - Google Patents
Полимерный материал с антимикробной активностью в отношении Proteus vulgaris Download PDFInfo
- Publication number
- MD4642C1 MD4642C1 MDA20180009A MD20180009A MD4642C1 MD 4642 C1 MD4642 C1 MD 4642C1 MD A20180009 A MDA20180009 A MD A20180009A MD 20180009 A MD20180009 A MD 20180009A MD 4642 C1 MD4642 C1 MD 4642C1
- Authority
- MD
- Moldova
- Prior art keywords
- furacilin
- proteus vulgaris
- dextran
- polymeric material
- activity against
- Prior art date
Links
- 241000588767 Proteus vulgaris Species 0.000 title claims abstract description 7
- 229940007042 proteus vulgaris Drugs 0.000 title claims abstract description 7
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 5
- 239000000463 material Substances 0.000 title claims description 7
- 229960001907 nitrofurazone Drugs 0.000 claims description 19
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 13
- 229920002307 Dextran Polymers 0.000 claims description 10
- 229920002521 macromolecule Polymers 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- 230000000844 anti-bacterial effect Effects 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000010899 nucleation Methods 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229940027988 antiseptic and disinfectant nitrofuran derivative Drugs 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 150000005676 cyclic carbonates Chemical class 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 1
- 229960001625 furazolidone Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000079 pharmacotherapeutic effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Изобретение относится к медицине и химии, в частности к разработке препаратов с антибактериальными свойствами в отношении Proteus vulgaris.Сущность изобретения состоит в том, что полимерный материал с антимикробной активностью в отношении Proteus vulgaris содержитфурацилин, привитый к макромолекулам декстрана в соотношении 50/50 мас.%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20180009A MD4642C1 (ru) | 2018-02-16 | 2018-02-16 | Полимерный материал с антимикробной активностью в отношении Proteus vulgaris |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20180009A MD4642C1 (ru) | 2018-02-16 | 2018-02-16 | Полимерный материал с антимикробной активностью в отношении Proteus vulgaris |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4642B1 MD4642B1 (ru) | 2019-08-31 |
| MD4642C1 true MD4642C1 (ru) | 2020-03-31 |
Family
ID=67874162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20180009A MD4642C1 (ru) | 2018-02-16 | 2018-02-16 | Полимерный материал с антимикробной активностью в отношении Proteus vulgaris |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4642C1 (ru) |
-
2018
- 2018-02-16 MD MDA20180009A patent/MD4642C1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MD4642B1 (ru) | 2019-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |