MD4399C1 - Полимерный материал с антибактериальными свойствами - Google Patents
Полимерный материал с антибактериальными свойствами Download PDFInfo
- Publication number
- MD4399C1 MD4399C1 MDA20150029A MD20150029A MD4399C1 MD 4399 C1 MD4399 C1 MD 4399C1 MD A20150029 A MDA20150029 A MD A20150029A MD 20150029 A MD20150029 A MD 20150029A MD 4399 C1 MD4399 C1 MD 4399C1
- Authority
- MD
- Moldova
- Prior art keywords
- polymeric material
- isofural
- mol
- antibacterial
- antibacterial properties
- Prior art date
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 title claims abstract description 21
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 21
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920001577 copolymer Polymers 0.000 claims abstract description 8
- -1 compound (E) -N '- ((5-nitrofuran- 2-yl) methylene) isonicotinhydrazide Chemical class 0.000 claims abstract description 4
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims abstract description 3
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000002861 polymer material Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 6
- 244000005700 microbiome Species 0.000 description 5
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229960001907 nitrofurazone Drugs 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 238000010899 nucleation Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 241000588767 Proteus vulgaris Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- PLHJDBGFXBMTGZ-WEVVVXLNSA-N furazolidone Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OCC1 PLHJDBGFXBMTGZ-WEVVVXLNSA-N 0.000 description 2
- 229960001625 furazolidone Drugs 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 229940007042 proteus vulgaris Drugs 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 201000000628 Gas Gangrene Diseases 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000370 acceptor Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 229920002118 antimicrobial polymer Polymers 0.000 description 1
- 229940027988 antiseptic and disinfectant nitrofuran derivative Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000004098 cellular respiration Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
Landscapes
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Изобретение относится к полимерному материалу с антибактериальными свойствами и может найти применение в медицине и ветеринарии.Полимерный материал, согласно изобретению, состоит из сополимера N-винилпирролидона с метакриловой или кротоновой кислотой, привитого соединением (E)-N'-((5-нитрофуран-2-ил)метилен)изоникотингидразид (изофурал).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20150029A MD4399C1 (ru) | 2015-02-19 | 2015-02-19 | Полимерный материал с антибактериальными свойствами |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20150029A MD4399C1 (ru) | 2015-02-19 | 2015-02-19 | Полимерный материал с антибактериальными свойствами |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4399B1 MD4399B1 (ru) | 2016-02-29 |
| MD4399C1 true MD4399C1 (ru) | 2016-09-30 |
Family
ID=55447191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20150029A MD4399C1 (ru) | 2015-02-19 | 2015-02-19 | Полимерный материал с антибактериальными свойствами |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4399C1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4506C1 (ru) * | 2016-11-24 | 2018-03-31 | Государственный Университет Молд0 | Полимерный материал с антибактериальными свойствами на основе лигнина привитый N'-(5-нитрофурфурилиден)изоникотингидразидом |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2042892A (en) * | 1979-02-05 | 1980-10-01 | Chinoin Gyogyszer Es Vegyeszet | Compositions of Improved Dispersability and Preparation Thereof |
| SU1731037A3 (ru) * | 1986-04-11 | 1992-04-30 | Басф Аг (Фирма) | Способ получени таблеток |
| MD196B1 (ro) * | 1994-07-22 | 1995-05-31 | Univ De Stat De Medicina N Tes | Izonicotinoilhidrazona a aldehidei 5-nitro-2-furanice |
| MD2380B2 (en) * | 2001-03-22 | 2004-02-29 | Heraeus Kulzer Gmbh & Co Kg | Polymer combination of antibiotic(s) and use thereof |
| RU2519679C2 (ru) * | 2008-06-30 | 2014-06-20 | Эббетт ГмбХ унд Ко. КГ | Фармацевтическая дозированная форма, содержащая полимерную композицию-носитель |
-
2015
- 2015-02-19 MD MDA20150029A patent/MD4399C1/ru not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2042892A (en) * | 1979-02-05 | 1980-10-01 | Chinoin Gyogyszer Es Vegyeszet | Compositions of Improved Dispersability and Preparation Thereof |
| SU1731037A3 (ru) * | 1986-04-11 | 1992-04-30 | Басф Аг (Фирма) | Способ получени таблеток |
| MD196B1 (ro) * | 1994-07-22 | 1995-05-31 | Univ De Stat De Medicina N Tes | Izonicotinoilhidrazona a aldehidei 5-nitro-2-furanice |
| MD2380B2 (en) * | 2001-03-22 | 2004-02-29 | Heraeus Kulzer Gmbh & Co Kg | Polymer combination of antibiotic(s) and use thereof |
| RU2519679C2 (ru) * | 2008-06-30 | 2014-06-20 | Эббетт ГмбХ унд Ко. КГ | Фармацевтическая дозированная форма, содержащая полимерную композицию-носитель |
Non-Patent Citations (1)
| Title |
|---|
| Timofeeva L., Kleshcheva N. Antimicrobial polymers: mechanism of action, factors of activity, and applications. Applied Microbiology and Biotechnology, 2011, vol. 89, nr. 3, p. 475-492 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4399B1 (ru) | 2016-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |