MD4232C1 - Remediu medicamentos pe bază de troxerutin şi carbazocrom pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă - Google Patents
Remediu medicamentos pe bază de troxerutin şi carbazocrom pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă Download PDFInfo
- Publication number
- MD4232C1 MD4232C1 MDA20120103A MD20120103A MD4232C1 MD 4232 C1 MD4232 C1 MD 4232C1 MD A20120103 A MDA20120103 A MD A20120103A MD 20120103 A MD20120103 A MD 20120103A MD 4232 C1 MD4232 C1 MD 4232C1
- Authority
- MD
- Moldova
- Prior art keywords
- treatment
- heart failure
- troxerutin
- carbazochrome
- hepatic cirrhosis
- Prior art date
Links
- 208000019425 cirrhosis of liver Diseases 0.000 title claims abstract description 18
- 206010019280 Heart failures Diseases 0.000 title claims abstract description 9
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 title claims abstract description 8
- 229960003232 troxerutin Drugs 0.000 title claims abstract description 8
- XSXCZNVKFKNLPR-SDQBBNPISA-N carbazochrome Chemical compound NC(=O)N/N=C/1C(=O)C=C2N(C)CC(O)C2=C\1 XSXCZNVKFKNLPR-SDQBBNPISA-N 0.000 title claims abstract description 7
- 229960002631 carbazochrome Drugs 0.000 title claims abstract description 7
- 239000003814 drug Substances 0.000 title abstract description 5
- 230000000750 progressive effect Effects 0.000 title abstract 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 2
- 206010018092 Generalised oedema Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000002425 cardiocirculatory effect Effects 0.000 description 2
- 201000002816 chronic venous insufficiency Diseases 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 208000008423 pleurisy Diseases 0.000 description 2
- 210000003240 portal vein Anatomy 0.000 description 2
- 208000027185 varicose disease Diseases 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 201000002282 venous insufficiency Diseases 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010065929 Cardiovascular insufficiency Diseases 0.000 description 1
- 208000000624 Esophageal and Gastric Varices Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 1
- 206010057267 Periphlebitis Diseases 0.000 description 1
- 208000014306 Trophic disease Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046996 Varicose vein Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000024783 anasarca Diseases 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960001476 pentoxifylline Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 210000003281 pleural cavity Anatomy 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120103A MD4232C1 (ro) | 2012-11-08 | 2012-11-08 | Remediu medicamentos pe bază de troxerutin şi carbazocrom pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20120103A MD4232C1 (ro) | 2012-11-08 | 2012-11-08 | Remediu medicamentos pe bază de troxerutin şi carbazocrom pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4232B1 MD4232B1 (en) | 2013-06-30 |
| MD4232C1 true MD4232C1 (ro) | 2014-01-31 |
Family
ID=48749683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20120103A MD4232C1 (ro) | 2012-11-08 | 2012-11-08 | Remediu medicamentos pe bază de troxerutin şi carbazocrom pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4232C1 (mo) |
Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985003864A1 (en) * | 1984-03-01 | 1985-09-12 | Casley Smith John Royle | Treatment of high protein oedemas by direct application of benzo-pyrones |
| CH671021A5 (en) * | 1987-05-07 | 1989-07-31 | Espanola Prod Quimicos | Prodn. of hydroxy:ethylated diosmin mixts. - useful for treating intoxication |
| FR2661610A1 (fr) * | 1990-05-02 | 1991-11-08 | Rhone Poulenc Sante | Nouvelle forme lyophilisee de la diosmine et sa preparation. |
| FR2668705A1 (fr) * | 1990-11-06 | 1992-05-07 | Bouchara Sa | Nouvelles preparations dermiques a action phlebotonique et leur procede de preparation. |
| EP0541874A1 (fr) * | 1990-05-11 | 1993-05-19 | Jérôme CORBIERE | Compositions à base de diosmine |
| FR2692145A1 (fr) * | 1992-06-10 | 1993-12-17 | Bellon Labor Sa Roger | Nouvelle composition à usage topique contenant de la diosmine. |
| JPH08301757A (ja) * | 1995-05-10 | 1996-11-19 | Kureha Chem Ind Co Ltd | Ｈｓｐ４７合成抑制剤 |
| NZ280418A (en) * | 1994-11-08 | 1997-03-24 | Adir | Diosmin composition; effervescent granule, in tablet or sachet form containing micronised diosmin |
| CA2287363A1 (en) * | 1997-05-13 | 1998-11-19 | Remacle, Jose | Use of a pharmaceutical composition for treating and/or preventing ischemia |
| DE19922287A1 (de) * | 1998-05-15 | 1999-11-25 | Coletica Lyon | Flavonoidverbindungen und ihre Verwendung insbesondere in Kosmetika |
| JP2000023635A (ja) * | 1998-07-10 | 2000-01-25 | M P G Kk | 粉粒体栄養補助食品 |
| WO2000015237A1 (en) * | 1998-09-15 | 2000-03-23 | Korea Research Institute Of Bioscience And Biotechnology | Composition containing rutin and quercetin for preventing or treating elevated blood lipid level-related diseases |
| KR20000019719A (ko) * | 1998-09-15 | 2000-04-15 | 박호군 | 디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및 치료용조성물 |
| KR20010007625A (ko) * | 2000-10-06 | 2001-01-26 | 박호군 | 디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 |
| KR20010007624A (ko) * | 2000-10-06 | 2001-01-26 | 박호군 | 네오헤스페리딘 디하이드로칼콘을 포함하는 동맥경화증,고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물 |
| WO2002020030A2 (en) * | 2000-09-11 | 2002-03-14 | Michael D Stander | Use of buchu extracts for hypertension |
| WO2004032942A1 (fr) * | 2002-10-11 | 2004-04-22 | Laboratoires Innothera Sas | Formulation orale seche a visee phlebotonique et vasculoprotectrice pour le traitement de l'insuffisance veineuse, de la fragilite capillaire et de la crise hemorroidaire, sous forme pharmaceutique de comprime a croquer contenant de la diosmine |
| FR2857665A1 (fr) * | 2003-07-16 | 2005-01-21 | Centre Nat Rech Scient | Nouveaux derives de flavones, leur procede de preparation et compositions pharmaceutiques les contenant |
| US20060040911A1 (en) * | 2003-01-06 | 2006-02-23 | Liao Benedict S | Method for preventing and/or treating the cardiovascular and hepatic diseases induced by hyperlipidemia which comprises administered an effective amount of bioflavonoids extract derived from fructus crataegus (lipid metabolism and fructus crataegus) |
| CN1823807A (zh) * | 2006-01-11 | 2006-08-30 | 刘展欣 | 一种微粒化地奥司明和橙皮甙组合物栓剂 |
| EP1707192A2 (en) * | 2005-03-30 | 2006-10-04 | Therapicon Srl | Pharmaceutical composition |
| MX2007011002A (es) * | 2007-09-07 | 2009-03-09 | World Trade Imp Export Wtie Ag | Composicion farmaceutica que comprende la combinacion de diversos agentes venotonicos y vasoprotectores para el tratamiento de la insuficiencia venosa cronica. |
| MD3987C2 (ro) * | 2009-09-03 | 2010-07-31 | Георге АНГЕЛИЧ | Utilizare a Diosminei pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă |
-
2012
- 2012-11-08 MD MDA20120103A patent/MD4232C1/ro not_active IP Right Cessation
Patent Citations (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985003864A1 (en) * | 1984-03-01 | 1985-09-12 | Casley Smith John Royle | Treatment of high protein oedemas by direct application of benzo-pyrones |
| CH671021A5 (en) * | 1987-05-07 | 1989-07-31 | Espanola Prod Quimicos | Prodn. of hydroxy:ethylated diosmin mixts. - useful for treating intoxication |
| FR2661610A1 (fr) * | 1990-05-02 | 1991-11-08 | Rhone Poulenc Sante | Nouvelle forme lyophilisee de la diosmine et sa preparation. |
| EP0541874A1 (fr) * | 1990-05-11 | 1993-05-19 | Jérôme CORBIERE | Compositions à base de diosmine |
| FR2668705A1 (fr) * | 1990-11-06 | 1992-05-07 | Bouchara Sa | Nouvelles preparations dermiques a action phlebotonique et leur procede de preparation. |
| FR2692145A1 (fr) * | 1992-06-10 | 1993-12-17 | Bellon Labor Sa Roger | Nouvelle composition à usage topique contenant de la diosmine. |
| FR2692145B1 (fr) * | 1992-06-10 | 1995-05-05 | Bellon Labor Sa Roger | Nouvelle composition à usage topique contenant de la diosmine. |
| NZ280418A (en) * | 1994-11-08 | 1997-03-24 | Adir | Diosmin composition; effervescent granule, in tablet or sachet form containing micronised diosmin |
| JPH08301757A (ja) * | 1995-05-10 | 1996-11-19 | Kureha Chem Ind Co Ltd | Ｈｓｐ４７合成抑制剤 |
| CA2287363A1 (en) * | 1997-05-13 | 1998-11-19 | Remacle, Jose | Use of a pharmaceutical composition for treating and/or preventing ischemia |
| DE19922287A1 (de) * | 1998-05-15 | 1999-11-25 | Coletica Lyon | Flavonoidverbindungen und ihre Verwendung insbesondere in Kosmetika |
| JP2000023635A (ja) * | 1998-07-10 | 2000-01-25 | M P G Kk | 粉粒体栄養補助食品 |
| WO2000015237A1 (en) * | 1998-09-15 | 2000-03-23 | Korea Research Institute Of Bioscience And Biotechnology | Composition containing rutin and quercetin for preventing or treating elevated blood lipid level-related diseases |
| KR20000019719A (ko) * | 1998-09-15 | 2000-04-15 | 박호군 | 디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및 치료용조성물 |
| WO2002020030A2 (en) * | 2000-09-11 | 2002-03-14 | Michael D Stander | Use of buchu extracts for hypertension |
| KR20010007625A (ko) * | 2000-10-06 | 2001-01-26 | 박호군 | 디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 |
| KR20010007624A (ko) * | 2000-10-06 | 2001-01-26 | 박호군 | 네오헤스페리딘 디하이드로칼콘을 포함하는 동맥경화증,고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물 |
| WO2004032942A1 (fr) * | 2002-10-11 | 2004-04-22 | Laboratoires Innothera Sas | Formulation orale seche a visee phlebotonique et vasculoprotectrice pour le traitement de l'insuffisance veineuse, de la fragilite capillaire et de la crise hemorroidaire, sous forme pharmaceutique de comprime a croquer contenant de la diosmine |
| US20060040911A1 (en) * | 2003-01-06 | 2006-02-23 | Liao Benedict S | Method for preventing and/or treating the cardiovascular and hepatic diseases induced by hyperlipidemia which comprises administered an effective amount of bioflavonoids extract derived from fructus crataegus (lipid metabolism and fructus crataegus) |
| FR2857665A1 (fr) * | 2003-07-16 | 2005-01-21 | Centre Nat Rech Scient | Nouveaux derives de flavones, leur procede de preparation et compositions pharmaceutiques les contenant |
| EP1707192A2 (en) * | 2005-03-30 | 2006-10-04 | Therapicon Srl | Pharmaceutical composition |
| CN1823807A (zh) * | 2006-01-11 | 2006-08-30 | 刘展欣 | 一种微粒化地奥司明和橙皮甙组合物栓剂 |
| MX2007011002A (es) * | 2007-09-07 | 2009-03-09 | World Trade Imp Export Wtie Ag | Composicion farmaceutica que comprende la combinacion de diversos agentes venotonicos y vasoprotectores para el tratamiento de la insuficiencia venosa cronica. |
| MD3987C2 (ro) * | 2009-09-03 | 2010-07-31 | Георге АНГЕЛИЧ | Utilizare a Diosminei pentru tratamentul cirozei hepatice avansate asociate cu insuficienţă cardiacă |
Non-Patent Citations (1)
| Title |
|---|
| Matcovschi C., Procopişin V., Parii B. Compendium Medicamentorum. Tipografia Centrală, Chişinău, 2001, p. 759 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4232B1 (en) | 2013-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) |