CN103446119B - Fluevirosines A在制备治疗急性肾衰药物中的应用 - Google Patents
Fluevirosines A在制备治疗急性肾衰药物中的应用 Download PDFInfo
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- CN103446119B CN103446119B CN201310432836.4A CN201310432836A CN103446119B CN 103446119 B CN103446119 B CN 103446119B CN 201310432836 A CN201310432836 A CN 201310432836A CN 103446119 B CN103446119 B CN 103446119B
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- fluevirosines
- renal failure
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- 208000033626 Renal failure acute Diseases 0.000 title claims abstract description 32
- 201000011040 acute kidney failure Diseases 0.000 title claims abstract description 32
- 208000009304 Acute Kidney Injury Diseases 0.000 title claims abstract description 31
- 208000012998 acute renal failure Diseases 0.000 title claims abstract description 31
- 229930193033 fluevirosine Natural products 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 229940079593 drug Drugs 0.000 title abstract description 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 12
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- 241000700159 Rattus Species 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 206010030302 Oliguria Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000003907 kidney function Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 201000003126 Anuria Diseases 0.000 description 3
- 240000007003 Flueggea virosa Species 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 230000008436 biogenesis Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
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- 238000010255 intramuscular injection Methods 0.000 description 3
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- 230000008327 renal blood flow Effects 0.000 description 3
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- 230000017531 blood circulation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000005084 renal tissue Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
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- 208000037887 cell injury Diseases 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310432836.4A CN103446119B (zh) | 2013-09-22 | 2013-09-22 | Fluevirosines A在制备治疗急性肾衰药物中的应用 |
Applications Claiming Priority (1)
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CN201310432836.4A CN103446119B (zh) | 2013-09-22 | 2013-09-22 | Fluevirosines A在制备治疗急性肾衰药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103446119A CN103446119A (zh) | 2013-12-18 |
CN103446119B true CN103446119B (zh) | 2015-07-15 |
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CN201310432836.4A Expired - Fee Related CN103446119B (zh) | 2013-09-22 | 2013-09-22 | Fluevirosines A在制备治疗急性肾衰药物中的应用 |
Country Status (1)
Country | Link |
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CN (1) | CN103446119B (zh) |
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2013
- 2013-09-22 CN CN201310432836.4A patent/CN103446119B/zh not_active Expired - Fee Related
Non-Patent Citations (3)
Title |
---|
Chemical synthesis and biological activities of securinega alkaloids;Wen Zhang;《Journal of Chinese Pharmaceutical Sciences》;20111230;第20卷;全文 * |
Fluevirosines A-C:A Biogenesis Inspired;Hua Zhang;《ORGANIC LETTERS》;20130130;第15卷(第1期);第121页及123页和表1 * |
新型海洋双吲哚类生物碱的研究进展;谷晓辉;《有机化学》;20000228;第20卷(第2期);全文 * |
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