CN103655538B - Hippolachnin A在治疗急性肾衰药物中的应用 - Google Patents
Hippolachnin A在治疗急性肾衰药物中的应用 Download PDFInfo
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- CN103655538B CN103655538B CN201310652101.2A CN201310652101A CN103655538B CN 103655538 B CN103655538 B CN 103655538B CN 201310652101 A CN201310652101 A CN 201310652101A CN 103655538 B CN103655538 B CN 103655538B
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- renal failure
- hippolachnin
- acute renal
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- medicine
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- 208000033626 Renal failure acute Diseases 0.000 title claims abstract description 31
- 201000011040 acute kidney failure Diseases 0.000 title claims abstract description 31
- 208000009304 Acute Kidney Injury Diseases 0.000 title claims abstract description 30
- 208000012998 acute renal failure Diseases 0.000 title claims abstract description 30
- QJEFDFUVBWNBLH-NYHZXQEESA-N hippolachnin a Chemical compound O1\C(=C/C(=O)OC)[C@@]2(CC)[C@H](CC)[C@]3(C)[C@@]2(C)[C@@]1(CC)C[C@H]3CC QJEFDFUVBWNBLH-NYHZXQEESA-N 0.000 title claims abstract description 28
- QRFJLYNQGMBFHB-ZONPTYSKSA-N hippolachnin A Natural products CC[C@@H]1C[C@@]2(CC)OC(=C/C(=O)OC)[C@@]3(CC)[C@H](CC)[C@@H]1[C@@H]23 QRFJLYNQGMBFHB-ZONPTYSKSA-N 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 12
- 230000000694 effects Effects 0.000 abstract description 4
- 241000700159 Rattus Species 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 230000003907 kidney function Effects 0.000 description 5
- 206010030302 Oliguria Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 201000003126 Anuria Diseases 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- 229940121375 antifungal agent Drugs 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 229930001119 polyketide Natural products 0.000 description 3
- 150000003881 polyketide derivatives Chemical class 0.000 description 3
- 230000008327 renal blood flow Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000005084 renal tissue Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241001593780 Hippospongia lachne Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310652101.2A CN103655538B (zh) | 2013-12-05 | 2013-12-05 | Hippolachnin A在治疗急性肾衰药物中的应用 |
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CN201310652101.2A CN103655538B (zh) | 2013-12-05 | 2013-12-05 | Hippolachnin A在治疗急性肾衰药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103655538A CN103655538A (zh) | 2014-03-26 |
CN103655538B true CN103655538B (zh) | 2015-09-23 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN201310652101.2A Active CN103655538B (zh) | 2013-12-05 | 2013-12-05 | Hippolachnin A在治疗急性肾衰药物中的应用 |
Country Status (1)
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CN (1) | CN103655538B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102603689A (zh) * | 2011-05-31 | 2012-07-25 | 上海长征医院 | 降二萜类化合物莱茄萜a及其制备方法和用途 |
-
2013
- 2013-12-05 CN CN201310652101.2A patent/CN103655538B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102603689A (zh) * | 2011-05-31 | 2012-07-25 | 上海长征医院 | 降二萜类化合物莱茄萜a及其制备方法和用途 |
Non-Patent Citations (3)
Title |
---|
Hippolachnin A, a new antifungal polyketide from the south china sea sponge hippospongia lachne;Shu-juan Piao等;《organic letters》;20130705;第15卷(第14期);3526-3529 * |
急性肾衰发病机制及肾保护研究新进展;王爱忠 等;《国外医学》;20001231;第21卷(第2期);84-86 * |
急性肾衰竭的治疗;张莉华;《中外健康文摘》;20130430;第10卷(第17期);6-8 * |
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CN103655538A (zh) | 2014-03-26 |
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