MD3638370T2 - Tratamentul migrenei cu acetil-leucină - Google Patents
Tratamentul migrenei cu acetil-leucină Download PDFInfo
- Publication number
- MD3638370T2 MD3638370T2 MDE20200433T MDE20200433T MD3638370T2 MD 3638370 T2 MD3638370 T2 MD 3638370T2 MD E20200433 T MDE20200433 T MD E20200433T MD E20200433 T MDE20200433 T MD E20200433T MD 3638370 T2 MD3638370 T2 MD 3638370T2
- Authority
- MD
- Moldova
- Prior art keywords
- leucine
- acetyl
- pharmaceutically acceptable
- migraine
- acceptable salt
- Prior art date
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1709459.0A GB201709459D0 (en) | 2017-06-14 | 2017-06-14 | Treatment for migraine |
| PCT/IB2018/054676 WO2018229738A1 (en) | 2017-06-14 | 2018-06-25 | Treatment for migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3638370T2 true MD3638370T2 (ro) | 2021-04-30 |
Family
ID=59358204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20200433T MD3638370T2 (ro) | 2017-06-14 | 2018-06-25 | Tratamentul migrenei cu acetil-leucină |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11471434B2 (https=) |
| EP (1) | EP3638370B1 (https=) |
| JP (1) | JP7130739B2 (https=) |
| KR (1) | KR102594130B1 (https=) |
| CN (1) | CN111093772B (https=) |
| AU (1) | AU2018284330B2 (https=) |
| CY (1) | CY1123860T1 (https=) |
| DK (1) | DK3638370T3 (https=) |
| ES (1) | ES2847169T3 (https=) |
| GB (1) | GB201709459D0 (https=) |
| HR (1) | HRP20210108T1 (https=) |
| HU (1) | HUE053089T2 (https=) |
| IL (1) | IL271211B2 (https=) |
| LT (1) | LT3638370T (https=) |
| MA (1) | MA49396B1 (https=) |
| MD (1) | MD3638370T2 (https=) |
| MX (1) | MX387909B (https=) |
| PL (1) | PL3638370T3 (https=) |
| PT (1) | PT3638370T (https=) |
| RS (1) | RS61481B1 (https=) |
| SG (1) | SG11201912146RA (https=) |
| SI (1) | SI3638370T1 (https=) |
| SM (1) | SMT202100037T1 (https=) |
| WO (1) | WO2018229738A1 (https=) |
| ZA (1) | ZA201908087B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA51836B1 (fr) * | 2018-02-15 | 2025-01-31 | Intrabio Ltd | Agents thérapeutiques permettant de traiter le syndrome des jambes sans repos |
| EP3886986A1 (en) | 2018-12-06 | 2021-10-06 | IntraBio Ltd | Deuterated analogs of acetyl-leucine |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8701662L (sv) * | 1987-04-22 | 1988-10-23 | Gelder Nico M Van | Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| US20060063827A1 (en) | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| SI1641775T1 (sl) * | 2003-07-03 | 2009-08-31 | Euro Celtique Sa | 2-piridin alkinski derivati, uporabni za zdravljenje bolečine |
| DE602004017316D1 (de) * | 2003-07-24 | 2008-12-04 | Euro Celtique Sa | Heteroaryl-tetrahydropyridylverbindungen, die sich für die behandlung bzw. die prävention von schmerzen eignen |
| SI1664016T1 (sl) * | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Terapevtska sredstva, uporabna za zdravljenje bolečine |
| PL1664041T3 (pl) * | 2003-09-22 | 2008-12-31 | Euro Celtique Sa | Przydatne do leczenia bólu związki fenylowo-karboksyamidowe |
| PL1727801T3 (pl) * | 2003-12-30 | 2009-08-31 | Euro Celtique Sa | Piperazyny użyteczne do leczenia bólu |
| FR2905600B1 (fr) * | 2006-09-13 | 2010-01-15 | Pf Medicament | Traitement des vertiges par l'acetyl-l-leucine. |
| TN2010000251A1 (fr) | 2010-06-03 | 2011-11-11 | Rekik Raouf | N-acetyl-dl-leucine medicament neuro et retino protecteur |
| US8921373B2 (en) * | 2010-06-22 | 2014-12-30 | Shionogi & Co., Ltd. | Compounds having TRPV1 antagonistic activity and uses thereof |
| LT2588130T (lt) | 2010-06-25 | 2016-12-12 | Shire Human Genetic Therapies, Inc. | Terapinės priemonės pristatymas cns |
| MX340112B (es) * | 2010-11-09 | 2016-06-27 | Mannkind Corp | Composicion que comprende un agonista de receptor de serotonina y una dicetopiperazina para el tratamiento de migrañas. |
| AU2012293417A1 (en) * | 2011-08-10 | 2013-05-02 | Purdue Pharma L.P. | TRPV1 antagonists including dihydroxy substituent and uses thereof |
| ES2994242T3 (en) | 2016-04-19 | 2025-02-05 | Intrabio Ltd | Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility |
| DK3359146T3 (en) | 2016-08-11 | 2019-04-08 | Intrabio Ltd | PHARMACEUTICAL COMPOSITIONS AND USES AGAINST LYSOSOMAL STORAGE DISEASES |
| WO2018029658A1 (en) | 2016-08-11 | 2018-02-15 | Intrabio Limited | Therapeutic agents for neurodegenerative diseases |
| HUE062729T2 (hu) | 2017-03-28 | 2023-12-28 | Intrabio Ltd | Betahisztin, vagy gyógyászatilag elfogadható sója, és egy monoamin-oxidáz inhibitor, egy alanyban szédülés egy vagy több tünete kezelésében vagy megelõzésében történõ alkalmazásra |
| IL273929B2 (en) | 2017-10-18 | 2024-11-01 | Intrabio Ltd | Therapeutic agents for neurodegenerative diseases |
| US12458614B2 (en) | 2017-10-18 | 2025-11-04 | Intrabio Ltd | Therapeutic agents for improved mobility and cognitive function and for treating neurodegenerative diseases and lysosomal storage disorders |
| MA51836B1 (fr) | 2018-02-15 | 2025-01-31 | Intrabio Ltd | Agents thérapeutiques permettant de traiter le syndrome des jambes sans repos |
| EP3886986A1 (en) | 2018-12-06 | 2021-10-06 | IntraBio Ltd | Deuterated analogs of acetyl-leucine |
| SMT202400334T1 (it) | 2019-03-02 | 2024-09-16 | Intrabio Ltd | (n-)acetil-l-leucina per il trattamento di lesioni cerebrali traumatiche |
| RS67283B1 (sr) | 2019-06-28 | 2025-11-28 | Intrabio Ltd | Kombinovana terapija sa acetil-leucinom i miglustatom za lečenje bolesti lizozomskog skladištenja |
| WO2021144720A1 (en) | 2020-01-13 | 2021-07-22 | Intrabio Ltd | Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers |
-
2017
- 2017-06-14 GB GBGB1709459.0A patent/GB201709459D0/en not_active Ceased
-
2018
- 2018-06-25 LT LTEP18749124.6T patent/LT3638370T/lt unknown
- 2018-06-25 ES ES18749124T patent/ES2847169T3/es active Active
- 2018-06-25 WO PCT/IB2018/054676 patent/WO2018229738A1/en not_active Ceased
- 2018-06-25 HR HRP20210108TT patent/HRP20210108T1/hr unknown
- 2018-06-25 JP JP2020519196A patent/JP7130739B2/ja active Active
- 2018-06-25 US US16/622,785 patent/US11471434B2/en active Active
- 2018-06-25 MD MDE20200433T patent/MD3638370T2/ro unknown
- 2018-06-25 PL PL18749124T patent/PL3638370T3/pl unknown
- 2018-06-25 AU AU2018284330A patent/AU2018284330B2/en active Active
- 2018-06-25 MX MX2019014784A patent/MX387909B/es unknown
- 2018-06-25 RS RS20210046A patent/RS61481B1/sr unknown
- 2018-06-25 PT PT187491246T patent/PT3638370T/pt unknown
- 2018-06-25 HU HUE18749124A patent/HUE053089T2/hu unknown
- 2018-06-25 SG SG11201912146RA patent/SG11201912146RA/en unknown
- 2018-06-25 MA MA49396A patent/MA49396B1/fr unknown
- 2018-06-25 DK DK18749124.6T patent/DK3638370T3/da active
- 2018-06-25 SI SI201830195T patent/SI3638370T1/sl unknown
- 2018-06-25 CN CN201880039532.2A patent/CN111093772B/zh active Active
- 2018-06-25 EP EP18749124.6A patent/EP3638370B1/en active Active
- 2018-06-25 IL IL271211A patent/IL271211B2/en unknown
- 2018-06-25 SM SM20210037T patent/SMT202100037T1/it unknown
- 2018-06-25 KR KR1020197038730A patent/KR102594130B1/ko active Active
-
2019
- 2019-12-05 ZA ZA2019/08087A patent/ZA201908087B/en unknown
-
2021
- 2021-01-18 CY CY20211100033T patent/CY1123860T1/el unknown
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