CN111093772B - 偏头痛的治疗 - Google Patents

偏头痛的治疗 Download PDF

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Publication number
CN111093772B
CN111093772B CN201880039532.2A CN201880039532A CN111093772B CN 111093772 B CN111093772 B CN 111093772B CN 201880039532 A CN201880039532 A CN 201880039532A CN 111093772 B CN111093772 B CN 111093772B
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CN
China
Prior art keywords
migraine
acetylleucine
application
pharmaceutically acceptable
leucine
Prior art date
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Active
Application number
CN201880039532.2A
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English (en)
Chinese (zh)
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CN111093772A (zh
Inventor
M·施特鲁普
M·法克拓尔
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Intrabio Ltd
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Intrabio Ltd
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Publication of CN111093772A publication Critical patent/CN111093772A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880039532.2A 2017-06-14 2018-06-25 偏头痛的治疗 Active CN111093772B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709459.0A GB201709459D0 (en) 2017-06-14 2017-06-14 Treatment for migraine
PCT/IB2018/054676 WO2018229738A1 (en) 2017-06-14 2018-06-25 Treatment for migraine

Publications (2)

Publication Number Publication Date
CN111093772A CN111093772A (zh) 2020-05-01
CN111093772B true CN111093772B (zh) 2023-11-03

Family

ID=59358204

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880039532.2A Active CN111093772B (zh) 2017-06-14 2018-06-25 偏头痛的治疗

Country Status (25)

Country Link
US (1) US11471434B2 (https=)
EP (1) EP3638370B1 (https=)
JP (1) JP7130739B2 (https=)
KR (1) KR102594130B1 (https=)
CN (1) CN111093772B (https=)
AU (1) AU2018284330B2 (https=)
CY (1) CY1123860T1 (https=)
DK (1) DK3638370T3 (https=)
ES (1) ES2847169T3 (https=)
GB (1) GB201709459D0 (https=)
HR (1) HRP20210108T1 (https=)
HU (1) HUE053089T2 (https=)
IL (1) IL271211B2 (https=)
LT (1) LT3638370T (https=)
MA (1) MA49396B1 (https=)
MD (1) MD3638370T2 (https=)
MX (1) MX387909B (https=)
PL (1) PL3638370T3 (https=)
PT (1) PT3638370T (https=)
RS (1) RS61481B1 (https=)
SG (1) SG11201912146RA (https=)
SI (1) SI3638370T1 (https=)
SM (1) SMT202100037T1 (https=)
WO (1) WO2018229738A1 (https=)
ZA (1) ZA201908087B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7337081B2 (ja) * 2018-02-15 2023-09-01 イントラバイオ リミティド レストレスレッグズ症候群を治療するための治療薬
JP7471298B2 (ja) * 2018-12-06 2024-04-19 イントラビオ エルティーディー アセチル－ロイシンの重水素化類似体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962121A (en) * 1987-04-22 1990-10-09 Anders Hamberger Method and composition for treating neurological diseases such as migraine
WO2008032222A2 (en) * 2006-09-13 2008-03-20 Pierre Fabre Medicament Treatment of vertigo with acetyl-l-leucine
CN103200940A (zh) * 2010-11-09 2013-07-10 曼金德公司 用于治疗偏头痛的包含血清素受体激动剂和二酮哌嗪的组合物

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US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
US20060063827A1 (en) 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
MY142655A (en) * 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
SI1641775T1 (sl) * 2003-07-03 2009-08-31 Euro Celtique Sa 2-piridin alkinski derivati, uporabni za zdravljenje bolečine
SI1867644T1 (sl) * 2003-07-24 2009-10-31 Euro Celtique Sa Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine
EP1664041B1 (en) * 2003-09-22 2008-07-02 Euro-Celtique S.A. Phenyl-carboxamide compounds useful for treating pain
PL1664016T3 (pl) * 2003-09-22 2009-04-30 Euro Celtique Sa Środki terapeutyczne przydatne do leczenia bólu
ES2322907T3 (es) * 2003-12-30 2009-07-01 Euro-Celtique S.A. Piperazinas utiles para el tratamiento de dolor.
TN2010000251A1 (fr) 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
WO2011162409A1 (en) * 2010-06-22 2011-12-29 Shionogi & Co., Ltd. Compounds having trpv1 antagonistic activity and uses thereof
SMT201600385T1 (it) 2010-06-25 2017-03-08 Shire Human Genetic Therapies Trasporto di agenti terapeutici all’snc
US9394293B2 (en) * 2011-08-10 2016-07-19 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
US10905670B2 (en) 2016-04-19 2021-02-02 Intrabio Ltd. Acetyl-leucine or a pharmaceutically acceptable salt thereof for improved mobility and cognitive function
NZ750391A (en) 2016-08-11 2026-03-27 Intrabio Ltd Pharmaceutical compositions and uses directed to lysosomal storage disorders
WO2018029658A1 (en) 2016-08-11 2018-02-15 Intrabio Limited Therapeutic agents for neurodegenerative diseases
FI3600276T3 (fi) 2017-03-28 2023-06-29 Intrabio Ltd Betahistiini tai sen farmaseuttisesti hyväksyttävä suola ja monoamiinioksidaasin inhibiittori käytettäväksi yhden tai useamman huimausoireen hoitamisessa tai ehkäisemisessä kohteessa
LT3697399T (lt) 2017-10-18 2026-01-12 Intrabio Ltd Terapiniai agentai, skirti panaudoti gydant neramių kojų sindromą
US12458614B2 (en) 2017-10-18 2025-11-04 Intrabio Ltd Therapeutic agents for improved mobility and cognitive function and for treating neurodegenerative diseases and lysosomal storage disorders
JP7337081B2 (ja) 2018-02-15 2023-09-01 イントラバイオ リミティド レストレスレッグズ症候群を治療するための治療薬
JP7471298B2 (ja) 2018-12-06 2024-04-19 イントラビオ エルティーディー アセチル－ロイシンの重水素化類似体
WO2020178721A1 (en) 2019-03-02 2020-09-10 Intrabio Ltd. Leucine, acetyl leucine, and related analogs for treating disease
SI3989962T1 (sl) 2019-06-28 2025-11-28 Intrabio Ltd Kombinirano zdravljenje z acetil-levcinom in miglustatom za zdravljenje lizosomske bolezni kopičenja
US20230051742A1 (en) 2020-01-13 2023-02-16 Intrabio Ltd. Treatment of late-onset neurodegenerative diseases in heterozygous npc1 gene mutation carriers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962121A (en) * 1987-04-22 1990-10-09 Anders Hamberger Method and composition for treating neurological diseases such as migraine
WO2008032222A2 (en) * 2006-09-13 2008-03-20 Pierre Fabre Medicament Treatment of vertigo with acetyl-l-leucine
CN103200940A (zh) * 2010-11-09 2013-07-10 曼金德公司 用于治疗偏头痛的包含血清素受体激动剂和二酮哌嗪的组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis;Izabela Domitrz等;CNS & Neurological Disorders - Drug Targets;第14卷(第3期);345-349 *

Also Published As

Publication number Publication date
CY1123860T1 (el) 2022-05-27
HUE053089T2 (hu) 2021-06-28
WO2018229738A1 (en) 2018-12-20
GB201709459D0 (en) 2017-07-26
RU2020100475A (ru) 2021-07-14
RS61481B1 (sr) 2021-03-31
CN111093772A (zh) 2020-05-01
JP7130739B2 (ja) 2022-09-05
ZA201908087B (en) 2024-11-27
PL3638370T3 (pl) 2021-05-17
RU2020100475A3 (https=) 2021-10-22
KR20210013518A (ko) 2021-02-04
AU2018284330B2 (en) 2024-03-14
SI3638370T1 (sl) 2021-04-30
ES2847169T3 (es) 2021-08-02
EP3638370A1 (en) 2020-04-22
HRP20210108T1 (hr) 2021-03-19
US11471434B2 (en) 2022-10-18
MA49396A (fr) 2020-04-22
IL271211B1 (en) 2023-09-01
MX2019014784A (es) 2021-11-16
DK3638370T3 (da) 2021-01-25
AU2018284330A1 (en) 2020-01-02
MD3638370T2 (ro) 2021-04-30
IL271211A (en) 2020-01-30
LT3638370T (lt) 2021-03-25
CA3067321A1 (en) 2018-12-20
EP3638370B1 (en) 2020-11-11
PT3638370T (pt) 2021-01-26
JP2020526575A (ja) 2020-08-31
US20200253905A1 (en) 2020-08-13
IL271211B2 (en) 2024-01-01
KR102594130B1 (ko) 2023-10-24
BR112019026660A2 (pt) 2020-07-14
MX387909B (es) 2025-03-19
MA49396B1 (fr) 2021-03-31
SG11201912146RA (en) 2020-01-30
SMT202100037T1 (it) 2021-03-15

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Address after: England Atsushi

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Address before: Ushizu gun

Applicant before: INTRABIO Ltd.

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