MD335Z - Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью - Google Patents
Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью Download PDFInfo
- Publication number
- MD335Z MD335Z MDS20100194A MDS20100194A MD335Z MD 335 Z MD335 Z MD 335Z MD S20100194 A MDS20100194 A MD S20100194A MD S20100194 A MDS20100194 A MD S20100194A MD 335 Z MD335 Z MD 335Z
- Authority
- MD
- Moldova
- Prior art keywords
- cervix
- labor
- induction
- pregnancy
- dose
- Prior art date
Links
- 230000006698 induction Effects 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims description 22
- 206010036877 Prolonged Pregnancy Diseases 0.000 title claims description 7
- 210000004291 uterus Anatomy 0.000 title description 3
- 208000032749 Pregnancy Diseases 0.000 title 1
- 210000003679 cervix uteri Anatomy 0.000 claims abstract description 23
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000006 Nitroglycerin Substances 0.000 claims description 12
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 12
- 210000001215 vagina Anatomy 0.000 claims description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 27
- 150000003180 prostaglandins Chemical class 0.000 description 27
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 11
- 230000005070 ripening Effects 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 210000003754 fetus Anatomy 0.000 description 8
- 230000035800 maturation Effects 0.000 description 8
- 230000000977 initiatory effect Effects 0.000 description 7
- 230000008774 maternal effect Effects 0.000 description 7
- 230000035935 pregnancy Effects 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 5
- 101800000989 Oxytocin Proteins 0.000 description 5
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000001605 fetal effect Effects 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 5
- 229960001723 oxytocin Drugs 0.000 description 5
- 206010067484 Adverse reaction Diseases 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 230000006838 adverse reaction Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 206010046790 Uterine hypertonus Diseases 0.000 description 3
- 210000001691 amnion Anatomy 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 229960005249 misoprostol Drugs 0.000 description 3
- 230000009984 peri-natal effect Effects 0.000 description 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 206010016855 Foetal distress syndrome Diseases 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 210000001136 chorion Anatomy 0.000 description 2
- 230000010339 dilation Effects 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 229930182833 estradiol Natural products 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000010297 mechanical methods and process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 1
- -1 Ca2+ ions Chemical class 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 108091000069 Cystinyl Aminopeptidase Proteins 0.000 description 1
- 102000030900 Cystinyl aminopeptidase Human genes 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- 208000032943 Fetal Distress Diseases 0.000 description 1
- 208000006893 Fetal Hypoxia Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 102000002397 Kinins Human genes 0.000 description 1
- 108010093008 Kinins Proteins 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 206010046820 Uterine rupture Diseases 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 230000001648 edemagenic effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008949 local secretion Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000968 medical method and process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 210000001883 posterior pituitary gland Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000004648 relaxation of smooth muscle Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000000276 sedentary effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009677 vaginal delivery Effects 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к медицине, в частности к акушерству и может быть использовано для подготовки шейки матки для индуцирования родов у беременных с беременностьюболее чем 41 неделя.Сущность изобретения состоит в том, что вводят таблетки Нитроглицерина ретард в задний форникс влагалища, в дозе 2,6…7,8 мг один раз в 12 часов, 1…3 раза.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20100194A MD335Z (ru) | 2010-11-19 | 2010-11-19 | Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20100194A MD335Z (ru) | 2010-11-19 | 2010-11-19 | Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD335Y MD335Y (en) | 2011-02-28 |
| MD335Z true MD335Z (ru) | 2011-10-31 |
Family
ID=45815032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDS20100194A MD335Z (ru) | 2010-11-19 | 2010-11-19 | Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD335Z (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4183C1 (ru) * | 2011-03-30 | 2013-05-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Метод лечения угрозы преждевременных родов при многоплодной монохориональной беременности |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD237G2 (ru) * | 1995-01-20 | 1995-12-31 | Intreprinderea Individuala "Medifarm-Diug" | Гидрогель для созревания шейки матки "Enzaprogel" |
| EA012391B1 (ru) * | 2004-11-11 | 2009-10-30 | Хсб Хэппи Чайлд Бёрт Холдинг Аг | Композиция для облегчения человеческих родов |
-
2010
- 2010-11-19 MD MDS20100194A patent/MD335Z/ru not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD237G2 (ru) * | 1995-01-20 | 1995-12-31 | Intreprinderea Individuala "Medifarm-Diug" | Гидрогель для созревания шейки матки "Enzaprogel" |
| EA012391B1 (ru) * | 2004-11-11 | 2009-10-30 | Хсб Хэппи Чайлд Бёрт Холдинг Аг | Композиция для облегчения человеческих родов |
Non-Patent Citations (9)
| Title |
|---|
| analysis of cervical softening. Am. J. Obstet. Gynecol., 1996, p.719-723 * |
| Bygdeman M., Marions L., Swahn M. Pregnancy termination. Steroids, 2000, p. 801-805. * |
| Bygdeman M., Marions L., Swahn M. Pregnancy termination. Steroids. 2000, p. 801-805 * |
| Gelber S., Sciscione A. Mechanical methods of cervical ripening and labor induction. Clin. Obstet. Gynecol., 2006, p. 642-657 * |
| Gelber S., Sciscione A. Mechanical methods of cervical ripening and labor induction. Clin. Obstet. Gynecol., 2006, p.642-657 * |
| Rechberger T., Abramson S.R., Woessner J.F. Jr. Onapristone and prostaglandin E2 induction of delivery in the rat in late pregnancy: a model for the * |
| Rechberger T., Abramson S.R., Woessner J.F. Jr. Onapristone and prostaglandin E2 induction of delivery in the rat in late pregnancy: a model for the analysis of cervical softening. Am. J. Obstet. Gynecol., 1996, p. 719-723 * |
| Аксененко В.А., Никольская Т.Н. Применение мизопростола для подготовки к родам. Материалы Российского форума «Мать и * |
| Аксененко В.А., Никольская Т.Н. Применение мизопростола для подготовки к родам. Материалы Российского форума «Мать и Дитя», Мoсква, 2001, с. 10-17 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4183C1 (ru) * | 2011-03-30 | 2013-05-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Метод лечения угрозы преждевременных родов при многоплодной монохориональной беременности |
Also Published As
| Publication number | Publication date |
|---|---|
| MD335Y (en) | 2011-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Athawale et al. | Effect of mifepristone in cervical ripening for induction of labour | |
| RU2012154445A (ru) | Интравагинальное введение мизопростола | |
| Calder | Prostaglandins and biological control of cervical function | |
| Berkane et al. | Use of mifepristone to ripen the cervix and induce labor in term pregnancies | |
| Aarnoudse et al. | Complications of cerclage | |
| Webster et al. | Interruption of first trimester human pregnancy following epostane therapy. Effect of prostaglandin E2 pessaries | |
| Herabutya et al. | A comparison of intravaginal misoprostol and intracervical prostaglandin E2 gel for ripening of unfavorable cervix and labor induction | |
| Barkai et al. | Induction of labor with use of a Foley catheter and extraamniotic corticosteroids | |
| Steiner et al. | Methods of cervical priming | |
| MD335Z (ru) | Метод подготовки шейки матки для индуцирования родов у беременных с переношенной беременностью | |
| MEIKLE et al. | A retrospective review of the efficacy and safety of prostaglandin E2 with premature rupture of the membranes at term | |
| RU2408375C1 (ru) | Способ подготовки к родам беременных с преждевременным излитием околоплодных вод при доношенном сроке | |
| Lyndrup et al. | Induction of labor by prostaglandin E2: intracervical gel or vaginal pessaries? | |
| EA031594B1 (ru) | Способ уменьшения дородового применения окситоцина и применение внутривлагалищного вкладыша по указанному назначению | |
| Aryana et al. | Magnesium sulphate and nifedipine in management of preterm premature rupture of membranes | |
| Amrutha | Comparative study of efficacy and safety of Mifepristone and Foley’s catheter in induction of labour | |
| Vellanki et al. | Is mifepristone a game changer in induction of labour | |
| Hofmeyr | Induction and augmentation of labour | |
| Fuchs | Prevention of premature birth | |
| Khatri et al. | Oral: Vaginal Misoprostol: Which route for induction of term labor? | |
| Fuller | Management of premature labor | |
| KESANI | COMPARATIVE STUDY OF 25 μg INTRAVAGINAL MISOPROSTOL AND 0.5 mg INTRACERVICAL DINOPROSTONE FOR INDUCTION OF LABOUR | |
| Gupta et al. | INDUCTION OF LABOUR—RECENT UPDATES | |
| Iqbal et al. | COMPARISON OF EFFICACY OF SUBLINGUAL MISOPROSTOL AND INTRACERVICAL DINOPROSTONE GEL FOR INDUCTION OF LABOUR | |
| RU2682574C1 (ru) | Способ подготовки шейки матки к родам с использованием комбинации мифепристона и осмотических расширителей. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KA4Y | Short-term patent lapsed due to non-payment of fees (with right of restoration) |