MD24Y - Method of differentiated treatment of non-invasive carcinoma of the mammary gland - Google Patents
Method of differentiated treatment of non-invasive carcinoma of the mammary gland Download PDFInfo
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- MD24Y MD24Y MDS20080029A MDS20080029A MD24Y MD 24 Y MD24 Y MD 24Y MD S20080029 A MDS20080029 A MD S20080029A MD S20080029 A MDS20080029 A MD S20080029A MD 24 Y MD24 Y MD 24Y
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- examination
- fibroadenomatosis
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- 210000005075 mammary gland Anatomy 0.000 title claims abstract description 11
- 201000004933 in situ carcinoma Diseases 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 39
- 201000003159 intraductal papilloma Diseases 0.000 claims abstract description 16
- 238000002604 ultrasonography Methods 0.000 claims abstract description 10
- 238000002271 resection Methods 0.000 claims abstract description 8
- 238000011835 investigation Methods 0.000 claims abstract description 7
- 210000001165 lymph node Anatomy 0.000 claims abstract description 5
- 208000004434 Calcinosis Diseases 0.000 claims description 28
- 206010057687 Bloody discharge Diseases 0.000 claims description 13
- 238000009607 mammography Methods 0.000 claims description 5
- 201000009030 Carcinoma Diseases 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract 2
- 208000003154 papilloma Diseases 0.000 abstract 2
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 description 8
- 238000002555 auscultation Methods 0.000 description 6
- 206010006187 Breast cancer Diseases 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 208000035211 Heart Murmurs Diseases 0.000 description 2
- 208000037656 Respiratory Sounds Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 238000012332 laboratory investigation Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000004115 mitral valve Anatomy 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 239000000082 organ preservation Substances 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 238000009527 percussion Methods 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 230000001020 rhythmical effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 201000005389 breast carcinoma in situ Diseases 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000011206 morphological examination Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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Abstract
Inventia se refera la medicina, in special la oncologia glandei mamare si poate fi utilizata pentru tratamentul diferentiat al carcinomului neinvaziv al glandei mamare. Esenta inventiei consta in aceea ca se efectueaza investigatii clinice, examenul ultrasonografic si mamografic si daca clinic se determina prezenta de tumoare sau induratie cu sau fara eliminari sangvinolente, la examenul ultrasonografic se determina prezenta de tumoare sau fibroadenomatoza localizata cu sau fara papilom intraductal cu microcalcifieri, la examenul mamografic se determina tumoare cu microcalcifieri mai mult de 15 cm2 si dupa Le Gal tipul IV-V, se efectueaza mastectomie. Daca se determina prezenta de tumoare sau induratie cu sau fara eliminari sangvinolente, la examenul ultrasonografic se determina prezenta de tumoare sau fibroadenomatoza localizata cu sau fara papilom intraductal cu microcalcifieri, la examenul mamografic se determina fibroadenomatoza localizata cu microcalcifieri de 10…15 cm2 si dupa Le Gal tipul III, se efectueaza rezectie sectoriala cu inlaturarea ganglionilor limfatici regionali. Daca se determina prezenta de tumoare cu sau fara eliminari sangvinolente, la examenul ultrasonografic se determina prezenta de fibroadenomatoza localizata cu sau fara papilom intraductal cu microcalcifieri, la examenul mamografic se determina prezenta de papilom intraductal cu microcalcifieri mai putin de 10 cm2, se efectueaza rezectie sectoriala cu margini de siguranta.The invention relates to medicine, in particular to mammary gland oncology and may be used for the differential treatment of non-invasive mammary gland carcinoma. The essence of the invention is that clinical investigations, ultrasonographic and mammographic examination are performed and if the presence of tumors or induration with or without bleeding is determined clinically, the ultrasonographic examination determines the presence of tumors or fibroadenomatosis localized with or without intraductal microcalyx papilloma, at the mammographic examination, tumors with microcalci ie more than 15 cm2 are determined and after Le Gal type IV-V, a mastectomy is performed. If the presence of tumor or induration is determined with or without bloody eliminations, the ultrasound examination determines the presence of tumor or localized fibroadenomatosis with or without intraductal papilloma with microcalcium, at the mammographic examination determine the localized fibroadenomatosis with microcalcium of 10 ... 15 cm2 and of 10 ... 15 cm2 At type III, sectoral resection is performed with the removal of the regional lymph nodes. If the presence of tumors with or without bleeding is determined, the ultrasonographic examination determines the presence of localized fibroadenomatosis with or without intraductal papilloma with microcalcium, at the mammographic examination the presence of intraductal papillom with microcalc ie less than 10 cm2, the sector is performed with safety edges.
Description
Invenţia se referă la medicină, în special la oncologia glandei mamare şi poate fi utilizată pentru determinarea tacticii de tratament intraoperator la pacientele cu suspecţie de carcinom neinvaziv al glandei mamare. The invention relates to medicine, in particular to breast oncology and can be used to determine intraoperative treatment tactics in patients with suspected non-invasive breast carcinoma.
Este cunoscută metoda de tratament combinat al cancerului glandei mamare, care constă în aceea că se efectuează radioterapia glandei mamare şi a sectoarelor de metastazare regională, în următoarea zi se efectuează mastectomia, după care urmează radioterapia postoperatorie [1]. The combined treatment method for breast cancer is known, which consists of performing radiotherapy to the breast and the areas of regional metastasis, followed by mastectomy the next day, followed by postoperative radiotherapy [1].
Este cunoscută metoda de tratament combinat, care constă în aceea că în perioada preoperatorie se efectuează radioterapia timp de 5 zile, câte 2 Gy în săptămână. Glanda mamară se iradiază pe două câmpuri opuse cu o doză sumară de 40…45 Gy. După aceasta, peste 1…2 săptămâni, se efectuează mastectomia radicală şi radioterapia plăgii postoperatorii sau se introduce aur coloidal radioactiv [2]. The combined treatment method is known, which consists in the fact that in the preoperative period radiotherapy is performed for 5 days, 2 Gy per week. The mammary gland is irradiated in two opposite fields with a total dose of 40…45 Gy. After this, in 1…2 weeks, radical mastectomy and radiotherapy of the postoperative wound are performed or radioactive colloidal gold is introduced [2].
Dezavantajele metodelor cunoscute constau în radioterapie în doze mari, care se răsfrânge negativ asupra stării generale a pacientei, se înrăutăţeşte starea imună a organismului, intervenţia chirurgicală efectuată nu este argumentată în unele forme de cancer de diferit stadiu, care se răsfrânge negativ asupra reabilitării pacientei, care provoacă dereglări estetice şi psihice la pacientele tinere. The disadvantages of known methods include high-dose radiotherapy, which negatively affects the patient's general condition, worsens the body's immune status, and surgical intervention is not justified in some forms of cancer of different stages, which negatively affects the patient's rehabilitation, causing aesthetic and psychological disorders in young patients.
Problema pe care o rezolvă invenţia constă în elaborarea unei metode de determinare a tacticii de tratament al carcinomului neinvaziv al glandei mamare pentru efectuarea unui tratament eficient pentru fiecare formă de cancer în parte, pentru a micşora numărul de recidive în formele cu o rată înaltă de recidivizare, pentru un tratament cosmetic eficient în unele forme care permit păstrarea organului, pentru eficientizarea triajului femeilor primar stabilite cu carcinom neinvaziv pentru efectuarea tratamentului eficient, pentru evitarea cheltuielilor şi a timpului pentru investigaţii suplimentare, care duce la micşorarea termenului de spitalizare. The problem solved by the invention consists in developing a method for determining the treatment tactics of non-invasive carcinoma of the mammary gland in order to perform an effective treatment for each form of cancer, to reduce the number of relapses in forms with a high relapse rate, for an effective cosmetic treatment in some forms that allow organ preservation, to streamline the triage of women with primary non-invasive carcinoma in order to perform effective treatment, to avoid expenses and time for additional investigations, which leads to a reduction in the length of hospitalization.
Esenţa invenţiei constă în aceea că se efectuează investigaţii clinice, examenul ultrasonografic şi mamografic şi dacă clinic se determină prezenţa de tumoare sau induraţie cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de tumoare sau fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină tumoare cu microcalcifieri mai mult de 15 cm2 şi după Le Gal tipul IV-V, se efectuează mastectomie. Dacă se determină prezenţa de tumoare sau induraţie cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de tumoare sau fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină fibroadenomatoză localizată cu microcalcifieri de 10…15 cm2 şi după Le Gal tipul III, se efectuează rezecţie sectorială cu înlăturarea ganglionilor limfatici regionali. Dacă se determină prezenţa de tumoare cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină prezenţa de papilom intraductal cu microcalcifieri mai puţin de 10 cm2, se efectuează rezecţie sectorială cu margini de siguranţă. The essence of the invention is that clinical investigations, ultrasonographic and mammographic examination are performed and if clinically the presence of tumor or induration with or without bloody discharges is determined, the ultrasonographic examination determines the presence of tumor or localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines tumor with microcalcifications more than 15 cm2 and according to Le Gal type IV-V, mastectomy is performed. If the presence of tumor or induration with or without bloody discharges is determined, the ultrasonographic examination determines the presence of tumor or localized fibroadenomatosis with or without bloody discharges, the mammographic examination determines tumor or localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines localized fibroadenomatosis with microcalcifications of 10…15 cm2 and according to Le Gal type III, sectoral resection is performed with removal of regional lymph nodes. If the presence of a tumor with or without bloody discharge is determined, the ultrasound examination determines the presence of localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines the presence of intraductal papilloma with microcalcifications less than 10 cm2, sectoral resection with safety margins is performed.
Rezultatul invenţiei constă în eficientizarea tratamentului pentru fiecare formă de cancer în parte, micşorarea numărului de recidive în formele cu o rată înaltă de apariţie a recidivelor, un tratament cosmetic eficient în unele forme care permit păstrarea organului, eficientizarea triajului femeilor primar stabilite cu carcinom neinvaziv cu efectuarea tratamentului eficient şi evitarea cheltuielilor şi a timpului suplimentar pentru investigaţii suplimentare, care duce la micşorarea termenului de spitalizare. The result of the invention consists in making the treatment more efficient for each form of cancer, reducing the number of relapses in forms with a high rate of relapses, an effective cosmetic treatment in some forms that allow preserving the organ, making the triage of women with primary non-invasive carcinoma more efficient by performing effective treatment and avoiding additional expenses and time for additional investigations, which leads to a reduction in the length of hospitalization.
Avantajele prezentei invenţii constau în determinarea rapidă a tacticii de tratament intraoperator în baza tabloului clinic şi examenului imagistic al fiecărei forme de carcinom neinvaziv, ceea ce duce la micşorarea numărului de recidive în formele cu o rată înaltă de apariţie a recidivelor, efectuarea unui tratament cosmetic eficient pentru unele forme care permit păstrarea organului, efectuarea unui triaj eficient al femeilor primar stabilite cu carcinom neinvaziv pentru stabilirea unui tratament eficient în lipsa posibilităţilor de efectuare a examenulului morfologic şi evitarea cheltuielilor şi a timpului pentru investigaţii suplimentare, care duce la micşorarea termenului de spitalizare. The advantages of the present invention consist in the rapid determination of the intraoperative treatment tactics based on the clinical picture and imaging examination of each form of non-invasive carcinoma, which leads to a decrease in the number of relapses in forms with a high recurrence rate, performing an effective cosmetic treatment for some forms that allow organ preservation, performing an effective triage of women with primary non-invasive carcinoma to establish an effective treatment in the absence of the possibilities of performing a morphological examination and avoiding expenses and time for additional investigations, which leads to a decrease in the length of hospitalization.
În timpul examinării pacientelor cu suspecţii la tumoare malignă a glandei mamare şi îndeosebi a carcinomului, semne clinice obiective sunt prezenţa de tumoare sau induraţie în glanda mamară cu sau fără eliminări sangvinolente. During the examination of patients with suspected malignant tumors of the mammary gland and especially carcinoma, objective clinical signs are the presence of tumor or induration in the mammary gland with or without bloody discharge.
La examenul ultrasonografic se poate determina prezenţa tumorii cu diferit număr de microcalcifieri la cm2 de ţesut sau fibroadenomatoză localizată cu sau fără papilom intraductal cu un număr diferit de microcalcifieri. La examenul mamografic poate fi determinată prezenţa tumorii, fibroadenomatozei localizate sau a papilomului intraductal cu un număr diferit de microcalcifieri de formă diferită, care au fost clasificate după Le Gal (Le Gal M. Chavanne G., Pellier D. Valeur diagnostique des microcalcifications groupees decouvertes par mammographie. Bull Cancer, 1984, 71, p. 57-64). După clasificarea Le Gal se disting 5 tipuri morfologice de microcalcifieri de valoare predictivă de malignizare în creştere. Tipul I - în formă de ceaşcă de ceai - 0% cancer, adică nu se întâlneşte în caz de tumoare malignă; tipul II - punctiforme - se întâlneşte la 20% de cancere mamare; tipul III - pulverulente - se întâlneşte la 39% de cancere mamare; tipul IV - punctiforme iregulate - se întâlneşte la 59% de cancere mamare şi tipul V - vermiculare - se întâlneşte la 96% de cancere mamare. The ultrasound examination can determine the presence of a tumor with a different number of microcalcifications per cm2 of tissue or localized fibroadenomatosis with or without intraductal papilloma with a different number of microcalcifications. The mammographic examination can determine the presence of a tumor, localized fibroadenomatosis or intraductal papilloma with a different number of microcalcifications of different shape, which were classified according to Le Gal (Le Gal M. Chavanne G., Pellier D. Valeur diagnostique des microcalcifications groupees decouvertes par mammographie. Bull Cancer, 1984, 71, p. 57-64). According to the Le Gal classification, 5 morphological types of microcalcifications with increasing predictive value for malignancy are distinguished. Type I - teacup-shaped - 0% cancer, i.e. it is not found in the case of a malignant tumor; type II - punctate - is found in 20% of breast cancers; type III - pulverulent - occurs in 39% of breast cancers; type IV - irregular punctate - occurs in 59% of breast cancers and type V - vermicular - occurs in 96% of breast cancers.
Metoda se efectuează în modul următor. The method is performed in the following way.
La pacientele cu suspecţie de carcinom neinvaziv al glandei mamare fără disgnostic morfologic se efectuează investigaţii clinice, examenul ultrasonografic şi mamografic şi dacă clinic se determină prezenţa de tumoare sau induraţie cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de tumoare sau fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină tumoare cu microcalcifieri mai mult de 15 cm2 şi după Le Gal tipul IV-V, se efectuează mastectomie. Dacă se determină prezenţa de tumoare sau induraţie cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de tumoare sau fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină fibroadenomatoză localizată cu microcalcifieri de 10…15 cm2 şi după Le Gal tipul III, se efectuează rezecţie sectorială cu înlăturarea ganglionilor limfatici regionali. Dacă se determină prezenţa de tumoare cu sau fără eliminări sangvinolente, la examenul ultrasonografic se determină prezenţa de fibroadenomatoză localizată cu sau fără papilom intraductal cu microcalcifieri, la examenul mamografic se determină prezenţa de papilom intraductal cu microcalcifieri mai puţin de 10 cm2, se efectuează rezecţie sectorială cu margini de siguranţă. In patients with suspected non-invasive carcinoma of the mammary gland without morphological diagnosis, clinical investigations, ultrasonographic and mammographic examination are performed and if clinically the presence of tumor or induration with or without bloody discharges is determined, the ultrasonographic examination determines the presence of tumor or localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines the presence of tumor with microcalcifications more than 15 cm2 and according to Le Gal type IV-V, mastectomy is performed. If the presence of tumor or induration with or without bloody discharges is determined, the ultrasonographic examination determines the presence of tumor or localized fibroadenomatosis with or without bloody discharges, the mammographic examination determines the presence of tumor or localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines localized fibroadenomatosis with microcalcifications of 10…15 cm2 and according to Le Gal type III, sectoral resection is performed with removal of regional lymph nodes. If the presence of a tumor with or without bloody discharge is determined, the ultrasound examination determines the presence of localized fibroadenomatosis with or without intraductal papilloma with microcalcifications, the mammographic examination determines the presence of intraductal papilloma with microcalcifications less than 10 cm2, sectoral resection with safety margins is performed.
Exemple de realizare Examples of implementation
Exemplul 1 Example 1
Pacienta C., în vârstă de 43 ani, la examenul profilactic obiectiv s-a depistat o induraţie la glanda mamară stângă, la examenul ultrasonografic s-a depistat fibroadenomatoză localizată cu microcalcifieri, la mamografie s-au depistat fibroadenomatoză localizată cu microcalcifieri, 10...15 cm2, Le Gal tipul III. Patient C., 43 years old, during the objective prophylactic examination, an induration was detected in the left mammary gland, during the ultrasound examination, localized fibroadenomatosis with microcalcifications was detected, during the mammography, localized fibroadenomatosis with microcalcifications, 10...15 cm2, Le Gal type III were detected.
Starea generală a pacientei la internare satisfăcătoare. Anamnestic: se consideră bolnavă de 4 luni. La examenul obiectiv general: aparatul respirator - stare normostenică, sunet pulmonar la percuţie, auscultativ - murmur vezicular prezent în ambele câmpuri pulmonare; cordul - limitele absolute şi relative ale matităţii cardiace în normă, auscultativ - zgomote cardiace ritmice cu suflu diastolic la auscultaţia valvulei mitrale; aparatul digestiv - ficat, splină nepalpabile, abdomenul moale, indolor la palpare. Investigaţie paraclinică - indicii hematologici în limitele normei. Pacienta a fost supusă tratamentului, şi anume rezecţiei sectoriale cu înlăturarea ganglionilor limfatici regionali. The patient's general condition upon admission was satisfactory. History: she was considered to have been ill for 4 months. On general objective examination: respiratory system - normostenic condition, lung sound on percussion, auscultation - vesicular murmur present in both lung fields; heart - absolute and relative limits of cardiac dullness within normal limits, auscultation - rhythmic heart sounds with diastolic murmur on auscultation of the mitral valve; digestive system - liver, spleen not palpable, soft abdomen, painless on palpation. Laboratory investigation - hematological indices within normal limits. The patient underwent treatment, namely sectoral resection with removal of regional lymph nodes.
Pacienta a fost externată în stare satisfăcătoare şi examinată periodic pe parcursul a 5 ani, recidive nu au fost depistate. The patient was discharged in satisfactory condition and examined periodically over 5 years, no relapses were detected.
Exemplul 2 Example 2
Pacienta A., în vârstă de 33 ani, la examenul profilactic obiectiv s-a depistat o tumoare cu eliminări sangvinolente din ductul glandei mamare stângi, la examenul ultrasonografic - tumoare cu microcalcifieri, la mamografie - tumoare cu microcalcifieri mai mult de 15 cm2, Le Gal tipul V. Patient A., 33 years old, during the objective prophylactic examination, a tumor with bloody discharges from the duct of the left mammary gland was detected, during the ultrasound examination - tumor with microcalcifications, during the mammography - tumor with microcalcifications more than 15 cm2, Le Gal type V.
Starea generală a pacientei la internare satisfăcătoare. Anamnestic: se consideră bolnavă de aproximativ 7 luni, cu o scădere ponderală de aproximativ 4 kg în ultimele 3 luni. La examenul obiectiv general: aparatul respirator - stare normostenică, sunet pulmonar la percuţie, auscultativ - murmur vezicular prezent în ambele câmpuri pulmonare; cordul - limitele absolute şi relative ale matităţii cardiace în normă, auscultativ - zgomote cardiace ritmice cu suflu diastolic la auscultaţia valvulei mitrale; aparatul digestiv - ficat, splină nepalpabile, abdomenul moale, indolor la palpare. The patient's general condition upon admission was satisfactory. History: she was considered ill for approximately 7 months, with a weight loss of approximately 4 kg in the last 3 months. On general objective examination: respiratory system - normostenic condition, lung sound on percussion, auscultation - vesicular murmur present in both lung fields; heart - absolute and relative limits of cardiac dullness within normal limits, auscultation - rhythmic heart sounds with diastolic murmur on auscultation of the mitral valve; digestive system - liver, spleen not palpable, abdomen soft, painless on palpation.
Investigaţie paraclinică - indicii hematologici în limitele normei. Laboratory investigation - hematological indices within normal limits.
Status localis: formaţiune tumorală palpabilă la nivelul sânului stâng, ce atinge dimensiuni de aproximativ 5x3 cm, localizată în cadranul inferior-lateral, nedureroasă, la mamografie s-a depistat tumoare cu microcalcifieri mai mult de 15 cm2, Le Gal tipul V. Status localis: palpable tumor formation in the left breast, reaching dimensions of approximately 5x3 cm, located in the lower-lateral quadrant, painless, mammography revealed a tumor with microcalcifications more than 15 cm2, Le Gal type V.
Pacienta a fost supusă mastectomiei radicale. The patient underwent radical mastectomy.
Pacienta a fost externată în stare satisfăcătoare şi examinată periodic pe parcursul a 5 ani, recidive nu au fost depistate. The patient was discharged in satisfactory condition and examined periodically over 5 years, no relapses were detected.
1. Павлов А.С., Фирсова П.П., Голдобенко Г.В., Даценко В.С., Строганова Л.Г., Илюхин С.А. Интенсивное предоперационное облучение больных раком молочной железы. Методические рекомендации. Обнинск, 1979, с. 3-9 1. Pavlov A.S., Firsova P.P., Goldobenko G.V., Datsenko V.S., Stroganova L.G., Ilyukhin S.A. Intensive preoperative irradiation of breast cancer patients. Methodological recommendations. Obninsk, 1979, p. 3-9
2. Козлова А.В. Лучевая терапия злокачественных опухолей. Москва, Медицина, 1976, с. 144-145 2. Kozlova A.V. Radiation therapy of malignant tumors. Moscow, Medicine, 1976, p. 144-145
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| MD106C2 (en) * | 1993-11-12 | 1995-06-30 | Онкологический Институт Республики Молдова | Method of treatment for mamma cancer |
| MD446G2 (en) * | 1995-07-07 | 1996-11-30 | Онкологический Институт Республики Молдова | Method for mamma cancer treatment |
| US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| YU42397A (en) * | 1996-10-30 | 2000-10-30 | Eli Lilly And Company | Using raloxiphene for medicine preparation |
| MD798G2 (en) * | 1996-11-15 | 1998-05-31 | Онкологический Институт Республики Молдова | Method of the mamma cancer treatment |
| MD962G2 (en) * | 1997-07-24 | 1998-12-31 | Онкологический Институт Республики Молдова | Method for radical mastectomy |
| ES2257817T3 (en) * | 1997-08-29 | 2006-08-01 | Biogen Idec Ma Inc. | METHODS AND COMPOSITIONS FOR THERAPIES AGAINST CANCER USING INTERFERON-BETA CODING GENES. |
| US6424864B1 (en) * | 1997-11-28 | 2002-07-23 | Masayuki Matsuura | Method and apparatus for wave therapy |
| US6333348B1 (en) * | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| MD1630G2 (en) * | 1999-06-04 | 2001-09-30 | Онкологический Институт Республики Молдова | Method of radical mastectomy in breast cancer |
| UA74798C2 (en) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Method for treating cancer in mammals using polypeptide interfering with interaction between april and its receptors |
| MD1569G2 (en) * | 1999-12-17 | 2001-06-30 | Онкологический Институт Республики Молдова | Method of treatment of breast canceeeer in the preoperation period |
| GB0005257D0 (en) * | 2000-03-03 | 2000-04-26 | Pharmacia & Upjohn Spa | Breast cancer hormonal therapy |
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
| MD2849G2 (en) * | 2005-05-16 | 2006-04-30 | Василе ЖОВМИР | Method of mammary cancer treatment to patients of old age |
| MD3248G2 (en) * | 2006-06-30 | 2007-09-30 | Василе ЖОВМИР | Method of mammary cancer treatment |
| MD3671G2 (en) * | 2007-11-02 | 2009-09-30 | Онкологический Институт Республики Молдова | Method of subtotal mastectomy in the mammary upper dial cancer |
| MD3772G2 (en) * | 2008-05-12 | 2009-07-31 | Общественное Медико-Санитарное Учреждение Онкологический Институт | Method for treating mammary cancer with metastases |
-
2008
- 2008-12-02 MD MDS20080029A patent/MD24Z/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MD24Z (en) | 2010-01-31 |
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| Date | Code | Title | Description |
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| KA4Y | Short-term patent lapsed due to non-payment of fees (with right of restoration) | ||
| MM4Y | Short-term patent definitely lapsed due to non-payment of fees |