MD20140107A2 - Anticorpi împotriva metaloproteinazei 9 din matrice - Google Patents
Anticorpi împotriva metaloproteinazei 9 din matriceInfo
- Publication number
- MD20140107A2 MD20140107A2 MDA20140107A MD20140107A MD20140107A2 MD 20140107 A2 MD20140107 A2 MD 20140107A2 MD A20140107 A MDA20140107 A MD A20140107A MD 20140107 A MD20140107 A MD 20140107A MD 20140107 A2 MD20140107 A2 MD 20140107A2
- Authority
- MD
- Moldova
- Prior art keywords
- antibodies
- matrix metalloproteinase
- mmp9
- functional fragment
- binding proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
- G01N2333/96491—Metalloendopeptidases (3.4.24) with definite EC number
- G01N2333/96494—Matrix metalloproteases, e. g. 3.4.24.7
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Invenţia se referă la imunologie, în special la compoziţii şi metode de utilizare a lor, care implică proteine de legare, de exemplu anticorpi şi fragmente de legare a antigenului acestora, care se leagă de metaloproteinaza matriceală-9 (MMP9) (MMP9 este cunoscută şi ca gelatinaza-B), cum ar fi în cazul în care proteinele de legare cuprind un lanţ imunoglobulinic greu (Ig) (fragmentul funcţional al acestuia) şi un lanţ uşor Ig (fragmentul funcţional al acestuia).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2012/027160 WO2013130078A1 (en) | 2012-02-29 | 2012-02-29 | Antibodies to matrix metalloproteinase 9 |
Publications (1)
Publication Number | Publication Date |
---|---|
MD20140107A2 true MD20140107A2 (ro) | 2015-03-31 |
Family
ID=45816000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20140107A MD20140107A2 (ro) | 2012-02-29 | 2012-02-29 | Anticorpi împotriva metaloproteinazei 9 din matrice |
Country Status (23)
Country | Link |
---|---|
US (4) | US9550836B2 (ro) |
EP (1) | EP2820048B1 (ro) |
JP (1) | JP6067756B2 (ro) |
KR (1) | KR20140130724A (ro) |
CN (1) | CN104395345A (ro) |
AP (1) | AP2014007907A0 (ro) |
AU (4) | AU2012318302C1 (ro) |
BR (1) | BR112014021477A2 (ro) |
CA (1) | CA2865530C (ro) |
CL (1) | CL2014002282A1 (ro) |
CO (1) | CO7061040A2 (ro) |
CR (1) | CR20140443A (ro) |
EA (1) | EA201491575A1 (ro) |
EC (1) | ECSP14020504A (ro) |
ES (1) | ES2731441T3 (ro) |
HK (2) | HK1205153A1 (ro) |
IN (1) | IN2014DN08011A (ro) |
MD (1) | MD20140107A2 (ro) |
MX (1) | MX2014010449A (ro) |
PH (1) | PH12014501931A1 (ro) |
SG (1) | SG11201405305PA (ro) |
WO (1) | WO2013130078A1 (ro) |
ZA (1) | ZA201406319B (ro) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2739505T3 (es) | 2010-08-27 | 2020-01-31 | Gilead Biologics Inc | Anticuerpos contra la metaloproteinasa 9 de la matriz |
CN104271156B (zh) | 2012-02-29 | 2017-06-16 | 吉利德生物制剂公司 | 抗基质金属蛋白酶9的抗体 |
AP2014007907A0 (en) | 2012-02-29 | 2014-08-31 | Gilead Biologics Inc | Antibodies to matrix metalloproteinase 9 |
TW201544511A (zh) * | 2014-02-27 | 2015-12-01 | Gilead Sciences Inc | 針對基質金屬蛋白酶9之抗體及其使用方法 |
EP2985295A1 (en) | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
EP2985296A1 (en) | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
CN105037553B (zh) * | 2015-08-20 | 2018-04-17 | 内蒙古蒙元生物基因科技有限公司 | 一种能够检测癌症的免疫球蛋白 |
AU2017248354A1 (en) | 2016-04-08 | 2018-10-04 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
US10326830B1 (en) * | 2016-09-02 | 2019-06-18 | Amazon Technologies, Inc. | Multipath tunneling to a service offered at several datacenters |
US10894837B2 (en) | 2016-12-16 | 2021-01-19 | Université De Bordeaux | MMP9 inhibitors and uses thereof in the prevention or treatment of a depigmenting disorder |
US10941178B2 (en) | 2017-03-17 | 2021-03-09 | Gilead Sciences, Inc. | Method of purifying an antibody |
WO2019017338A1 (ja) | 2017-07-18 | 2019-01-24 | 第一三共株式会社 | 活性型mmp-9結合ペプチド |
CN110885375B (zh) * | 2019-12-20 | 2021-07-02 | 南京融捷康生物科技有限公司 | 特异性针对mmp-9蛋白锌离子结合结构域的单域抗体及产品与应用 |
CN111785321B (zh) * | 2020-06-12 | 2022-04-05 | 浙江工业大学 | 一种基于深度卷积神经网络的dna绑定残基预测方法 |
CN117327186B (zh) * | 2023-07-12 | 2024-03-12 | 北京达成生物科技有限公司 | 结合mmp3蛋白的双特异性抗体及其用途 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
WO2001004157A2 (en) * | 1999-07-13 | 2001-01-18 | University Of Southern California | NOVEL METHOD AND COMPOSITION FOR INHIBITION OF ANGIOGENESIS USING ANTAGONISTS BASED ON MMP-9 AND β1 INTEGRINS |
CN1459505A (zh) * | 2002-05-21 | 2003-12-03 | 赵平 | 中国汉族人基质金属蛋白酶-9基因重构、表达、纯化及其医学应用 |
JP4601426B2 (ja) * | 2002-09-06 | 2010-12-22 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体成分c5に対する抗体を使用する喘息の処置の方法 |
KR101434682B1 (ko) * | 2005-12-02 | 2014-08-27 | 제넨테크, 인크. | 결합 폴리펩티드 및 이들의 용도 |
AR066913A1 (es) * | 2007-06-08 | 2009-09-23 | Irm Llc | Metodos y composiciones para inducir la apoptosis en celulas cancerosas |
WO2009111508A2 (en) * | 2008-03-03 | 2009-09-11 | Dyax Corp. | Metalloproteinase 9 and metalloproteinase 2 binding proteins |
WO2009111450A2 (en) * | 2008-03-03 | 2009-09-11 | Dyax Corp. | Metalloproteinase 9 binding proteins |
US20110262396A1 (en) * | 2008-10-22 | 2011-10-27 | Dyax Corp. | Combination treatments comprising protease binding proteins for inflammatory disorders |
US20110286916A1 (en) * | 2008-11-20 | 2011-11-24 | Jose Miguel Aste-Amezaga | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
WO2011092700A1 (en) * | 2010-01-27 | 2011-08-04 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
ES2739505T3 (es) * | 2010-08-27 | 2020-01-31 | Gilead Biologics Inc | Anticuerpos contra la metaloproteinasa 9 de la matriz |
AP2014007907A0 (en) | 2012-02-29 | 2014-08-31 | Gilead Biologics Inc | Antibodies to matrix metalloproteinase 9 |
CN104271156B (zh) | 2012-02-29 | 2017-06-16 | 吉利德生物制剂公司 | 抗基质金属蛋白酶9的抗体 |
-
2012
- 2012-02-29 AP AP2014007907A patent/AP2014007907A0/xx unknown
- 2012-02-29 US US14/382,301 patent/US9550836B2/en active Active
- 2012-02-29 CN CN201280072749.6A patent/CN104395345A/zh active Pending
- 2012-02-29 BR BR112014021477A patent/BR112014021477A2/pt not_active IP Right Cessation
- 2012-02-29 JP JP2014559872A patent/JP6067756B2/ja not_active Expired - Fee Related
- 2012-02-29 EP EP12708473.9A patent/EP2820048B1/en active Active
- 2012-02-29 MX MX2014010449A patent/MX2014010449A/es unknown
- 2012-02-29 EA EA201491575A patent/EA201491575A1/ru unknown
- 2012-02-29 WO PCT/US2012/027160 patent/WO2013130078A1/en active Application Filing
- 2012-02-29 SG SG11201405305PA patent/SG11201405305PA/en unknown
- 2012-02-29 MD MDA20140107A patent/MD20140107A2/ro not_active Application Discontinuation
- 2012-02-29 ES ES12708473T patent/ES2731441T3/es active Active
- 2012-02-29 AU AU2012318302A patent/AU2012318302C1/en not_active Ceased
- 2012-02-29 IN IN8011DEN2014 patent/IN2014DN08011A/en unknown
- 2012-02-29 CA CA2865530A patent/CA2865530C/en not_active Expired - Fee Related
- 2012-02-29 KR KR1020147026786A patent/KR20140130724A/ko not_active Application Discontinuation
-
2014
- 2014-08-27 ZA ZA2014/06319A patent/ZA201406319B/en unknown
- 2014-08-27 PH PH12014501931A patent/PH12014501931A1/en unknown
- 2014-08-28 CL CL2014002282A patent/CL2014002282A1/es unknown
- 2014-08-29 CO CO14190943A patent/CO7061040A2/es unknown
- 2014-09-24 CR CR20140443A patent/CR20140443A/es unknown
- 2014-09-26 EC ECIEPI201420504A patent/ECSP14020504A/es unknown
-
2015
- 2015-06-19 HK HK15105849.5A patent/HK1205153A1/xx unknown
- 2015-09-02 HK HK15108571.3A patent/HK1208036A1/xx unknown
- 2015-10-13 AU AU2015242967A patent/AU2015242967B2/en not_active Ceased
-
2016
- 2016-12-12 US US15/376,232 patent/US20170183421A1/en not_active Abandoned
-
2017
- 2017-08-16 AU AU2017216508A patent/AU2017216508B2/en not_active Ceased
- 2017-11-17 AU AU2017261626A patent/AU2017261626A1/en not_active Abandoned
-
2019
- 2019-01-10 US US16/245,169 patent/US10800857B2/en active Active
-
2020
- 2020-09-10 US US17/017,491 patent/US11634505B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD20140108A2 (ro) | Anticorpi împotriva metaloproteinazei 9 matriciale | |
PH12016501691A1 (en) | Antibodies to matrix metalloproteinase 9 | |
MD20140107A2 (ro) | Anticorpi împotriva metaloproteinazei 9 din matrice | |
AU2018256487A1 (en) | Antibodies that bind to TL1A and their uses | |
PH12014502527B1 (en) | St2 antigen binding proteins | |
EA201491214A1 (ru) | Композиции и способы применения антител, нацеленных на фактор p | |
EP4356927A3 (en) | Antibody based reagents that specifically recognize toxic oligomeric forms of tau | |
EA201591091A1 (ru) | Антигенсвязывающие белки для bcma | |
TN2011000528A1 (en) | Compositions and methods for antibodies targeting complement protein c3b | |
MX2017001959A (es) | Anticuerpos especificos para mmp9. | |
MX2015005719A (es) | Terapias de combinacion que usan moleculas de union anti-psl y pcrv de pseudomonas. | |
EA201291065A1 (ru) | Антитела против vla-4 | |
EA201990895A1 (ru) | Антитела к о1 и варианты их применения | |
EA201590918A1 (ru) | Антитела к bmp-6 | |
MX2016011177A (es) | Anticuerpos a la metaloproteinasa de matriz 9 y metodos de uso de los mismos. | |
CL2010000521A1 (es) | Anticuerpo aislado o fragmento que bloquea la fijacion de la union de la proteina wise; secuencias de cdr de la cadena liviana y pesada; polipeptido inmunogenico de wise; composicion farmaceutica que comprende dicho anticuerpo. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Abandonment or withdrawal of application (patent for invention) |