MD1432C2 - Metodă de tratament al stării dependente de estrogenii ovarieni - Google Patents

Metodă de tratament al stării dependente de estrogenii ovarieni Download PDF

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Publication number
MD1432C2
MD1432C2 MD96-0323A MD960323A MD1432C2 MD 1432 C2 MD1432 C2 MD 1432C2 MD 960323 A MD960323 A MD 960323A MD 1432 C2 MD1432 C2 MD 1432C2
Authority
MD
Moldova
Prior art keywords
treatment
state depending
estrogens
quantity sufficient
ovarian estrogens
Prior art date
Application number
MD96-0323A
Other languages
English (en)
Russian (ru)
Other versions
MD1432B2 (ro
Inventor
Gary D. Hodgen
Robert F. Willaims
Daniel Grow
Original Assignee
The Medical College Of Hampton Roads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Medical College Of Hampton Roads filed Critical The Medical College Of Hampton Roads
Publication of MD1432B2 publication Critical patent/MD1432B2/ro
Publication of MD1432C2 publication Critical patent/MD1432C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la medicină şi anume la ginecologie.Esenţa invenţiei constă în aceea că în administrarea analogului hormonului, ce eliberează gonadotropina, timp de cel puţin 30 de zile, în cantitate suficientă pentru reducerea nivelului de estrogeni circulanţi în sânge până la circa 20 pg/ml, suplimentar se administrează antiprogestină într-o cantitate suficientă pentru menţinerea acţiunii antiproliferative şi păstrarea ţesutului osos.Rezultatul este reducerea osteoporozei.
MD96-0323A 1994-02-04 1995-02-02 Metodă de tratament al stării dependente de estrogenii ovarieni MD1432C2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/191,631 US5681817A (en) 1994-02-04 1994-02-04 Treatment of ovarian estrogen dependent conditions
PCT/US1995/001479 WO1995020972A1 (en) 1994-02-04 1995-02-02 Treatment of ovarian estrogen dependent conditions

Publications (2)

Publication Number Publication Date
MD1432B2 MD1432B2 (ro) 2000-03-31
MD1432C2 true MD1432C2 (ro) 2000-09-30

Family

ID=22706258

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0323A MD1432C2 (ro) 1994-02-04 1995-02-02 Metodă de tratament al stării dependente de estrogenii ovarieni

Country Status (29)

Country Link
US (1) US5681817A (ro)
EP (1) EP0785792B1 (ro)
JP (1) JP3130048B2 (ro)
KR (1) KR970700507A (ro)
CN (1) CN1144486A (ro)
AP (1) AP724A (ro)
AT (1) ATE179610T1 (ro)
AU (1) AU689229B2 (ro)
BG (1) BG62238B1 (ro)
BR (1) BR9506606A (ro)
CA (1) CA2182183C (ro)
CZ (1) CZ291709B6 (ro)
DE (1) DE69509544T2 (ro)
DK (1) DK0785792T3 (ro)
ES (1) ES2132645T3 (ro)
FI (1) FI963036L (ro)
GR (1) GR3030164T3 (ro)
HU (1) HUT74622A (ro)
LT (1) LT4182B (ro)
LV (1) LV11782B (ro)
MD (1) MD1432C2 (ro)
NZ (1) NZ281441A (ro)
OA (1) OA10777A (ro)
PL (1) PL178273B1 (ro)
RO (1) RO117420B1 (ro)
RU (1) RU2110274C1 (ro)
SK (1) SK96296A3 (ro)
TJ (1) TJ242B (ro)
WO (1) WO1995020972A1 (ro)

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WO1996003138A1 (en) * 1994-07-22 1996-02-08 The Medical College Of Hampton Roads Establishment of tonic ovarian estrogen secretion for extended therapeutic regimens
US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US6274573B1 (en) 1997-10-17 2001-08-14 Mochida Pharmaceutical Co., Ltd. Method of treatment for uterine leiomyoma
US6703367B1 (en) 1999-04-27 2004-03-09 Praecis Pharmaceuticals Inc. Methods for treating hot flashes and gynaecomastia
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US8193252B1 (en) 1999-08-31 2012-06-05 Bayer Pharma AG Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
ES2295050T3 (es) * 1999-08-31 2008-04-16 Bayer Schering Pharma Aktiengesellschaft Mesoprogestinas para el tratamiento y la prevencion de trastornos ginecologicos benignos dependientes de hormonas.
UA73119C2 (en) * 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
AU2001295359A1 (en) * 2000-10-30 2002-05-15 University Of Zurich GnRH analogues for treatment of urinary incontinence
US6958142B2 (en) * 2002-08-02 2005-10-25 Balance Pharmaceuticals, Inc. Nasal spray formulation and method
US6960337B2 (en) * 2002-08-02 2005-11-01 Balance Pharmaceuticals, Inc. Methods and compositions for treating benign gynecological disorders
US7029657B2 (en) * 2002-08-02 2006-04-18 Balance Pharmaceuticals, Inc. Nasal spray steroid formulation and method
GB0302572D0 (en) 2003-02-05 2003-03-12 Astrazeneca Ab Method of treatment
EP1865935B1 (en) * 2005-02-17 2011-06-08 Hadasit Medical Research Services and Development Ltd. Bisphosphonates for treating endometriosis
US20060251581A1 (en) * 2005-05-09 2006-11-09 Mcintyre Jon T Method for treatment of uterine fibroid tumors
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
TWI455716B (zh) * 2006-10-24 2014-10-11 Repros Therapeutics Inc 選擇性黃體激素受體調節劑用於製造治療雌激素依賴性病症之藥物的用途
MY150763A (en) * 2006-10-24 2014-02-28 Repros Therapeutics Inc Compositions and methods for suppressing endometrial proliferation
WO2008144143A1 (en) * 2007-05-14 2008-11-27 Drugtech Corporation Endometriosis treatment
US20110208118A1 (en) * 2007-09-20 2011-08-25 Bio-Pro Medical Ltd. Compositions and means for treating uterine leiomyomata, leiomyoma, myoma, uterine fibroids, endometriosis, adenomyosis and related disorders by mifepristone
RU2359684C1 (ru) * 2008-01-23 2009-06-27 Закрытое акционерное общество "СКАЙ ЛТД" Способ лечения эндометриоза
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Also Published As

Publication number Publication date
BR9506606A (pt) 1997-09-09
CN1144486A (zh) 1997-03-05
LV11782A (lv) 1997-06-20
TJ242B (en) 1999-11-24
FI963036A0 (fi) 1996-08-01
FI963036A7 (fi) 1996-08-01
ES2132645T3 (es) 1999-08-16
SK96296A3 (en) 1997-07-09
OA10777A (en) 2002-12-23
AU689229B2 (en) 1998-03-26
LT4182B (en) 1997-06-25
DE69509544D1 (de) 1999-06-10
DK0785792T3 (da) 1999-10-18
EP0785792B1 (en) 1999-05-06
DE69509544T2 (de) 1999-09-02
RO117420B1 (ro) 2002-03-29
BG62238B1 (bg) 1999-06-30
PL178273B1 (pl) 2000-03-31
BG100766A (bg) 1997-06-30
GR3030164T3 (en) 1999-08-31
MD1432B2 (ro) 2000-03-31
CA2182183C (en) 2003-09-16
WO1995020972A1 (en) 1995-08-10
AP9600840A0 (en) 1996-07-31
EP0785792A4 (ro) 1997-07-30
CA2182183A1 (en) 1995-08-10
US5681817A (en) 1997-10-28
CZ291709B6 (cs) 2003-05-14
EP0785792A1 (en) 1997-07-30
JPH09508418A (ja) 1997-08-26
FI963036L (fi) 1996-08-01
NZ281441A (en) 1999-09-29
RU2110274C1 (ru) 1998-05-10
ATE179610T1 (de) 1999-05-15
LT96133A (en) 1997-01-27
LV11782B (en) 1997-12-20
AU1838695A (en) 1995-08-21
CZ210396A3 (en) 1997-05-14
JP3130048B2 (ja) 2001-01-31
PL315792A1 (en) 1996-12-09
AP724A (en) 1999-01-18
KR970700507A (ko) 1997-02-12
HUT74622A (en) 1997-01-28
HU9601969D0 (en) 1996-09-30

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