MD119C2 - Procedeu de obţinere a derivaţilor acidului 2-tieniloxiacetic sau a sărurilor lor utilizate în farmaceutică - Google Patents
Procedeu de obţinere a derivaţilor acidului 2-tieniloxiacetic sau a sărurilor lor utilizate în farmaceuticăInfo
- Publication number
- MD119C2 MD119C2 MD94-0142A MD940142A MD119C2 MD 119 C2 MD119 C2 MD 119C2 MD 940142 A MD940142 A MD 940142A MD 119 C2 MD119 C2 MD 119C2
- Authority
- MD
- Moldova
- Prior art keywords
- ethyl
- acide
- thienyloxiacetic
- obtaining
- derivatives
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 abstract 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 229910001923 silver oxide Inorganic materials 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XQGZSYKGWHUSDH-UHFFFAOYSA-N dazoxiben Chemical compound C1=CC(C(=O)O)=CC=C1OCCN1C=NC=C1 XQGZSYKGWHUSDH-UHFFFAOYSA-N 0.000 abstract 1
- 229950008000 dazoxiben Drugs 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 206010025482 malaise Diseases 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la derivaţii acidului 2-tienil-oxiacetic, în special la obţinerea acizilor 5-[2-(benzensulfonilamino) etil] - sau 5-[2-(4-clorbenzensulfonilamino) etil]-2 tieniloxiacetici care pot fi întrebuinţaţi în medicină pentru tratarea bolilor trombolice.Scopul constă în crearea substanţelor noi cu activitatea mai sporită din clasa indicată. Sinteza se efectueză prin oxidare, de exemplu, a amidei acidului N-[2-[2-(5-(2-hidroxi)-etoxi)-tienil]-etil]-benzosulfonic cu oxid de argint în mediul acva-bazic. Amida se dizolvă în soluţia de KOH sau NaOH cu concentraţia 0,5-4n, preferenţial de 2n, se oxidează cu 2-16 echivalenţi de oxid de argint la temperatura de 75-85 °C timp de 2-3 ore.Oxidul de argint iniţial se obţine prealabil prin dizolvarea AgNO3 în apă distilată şi se adaugă cantităţi echimolare de NaOH. Produsul cu destinaţie specială se separă în stare liberă sau în formă de sare farmaceutic acceptabilă. Compuşii noi sunt puţin toxici şi de 4 ori mai activi decât dazoxibenul, începutul acţiunii antitrombinice observându-se la 1 mg/kg şi atinge nivelul maxim la 5 mg/kg contra 20 mg/kg.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT82087 | 1987-04-03 | ||
| SU884355476A SU1574176A3 (ru) | 1987-04-03 | 1988-04-01 | Способ получени производных 2-тиенилоксиуксусной кислоты или их фармацевтически применимых солей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD119B1 MD119B1 (ro) | 1994-12-31 |
| MD119C2 true MD119C2 (ro) | 1995-07-31 |
Family
ID=25594008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0142A MD119C2 (ro) | 1987-04-03 | 1994-04-14 | Procedeu de obţinere a derivaţilor acidului 2-tieniloxiacetic sau a sărurilor lor utilizate în farmaceutică |
Country Status (2)
| Country | Link |
|---|---|
| LV (1) | LV5499A3 (ro) |
| MD (1) | MD119C2 (ro) |
-
1993
- 1993-11-17 LV LV931245A patent/LV5499A3/xx unknown
-
1994
- 1994-04-14 MD MD94-0142A patent/MD119C2/ro active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| Бюлер К., Пирсон Д., Органические синтезы - М.: Мир, 1973, ч. 2, с. 239 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD119B1 (ro) | 1994-12-31 |
| LV5499A3 (lv) | 1994-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20080331 |