MD119C2 - The method of obtaining of derivatives 2 thienyloxiacetic acide or of salt useful in pharmaceutic - Google Patents
The method of obtaining of derivatives 2 thienyloxiacetic acide or of salt useful in pharmaceuticInfo
- Publication number
- MD119C2 MD119C2 MD94-0142A MD940142A MD119C2 MD 119 C2 MD119 C2 MD 119C2 MD 940142 A MD940142 A MD 940142A MD 119 C2 MD119 C2 MD 119C2
- Authority
- MD
- Moldova
- Prior art keywords
- ethyl
- acide
- thienyloxiacetic
- obtaining
- derivatives
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 abstract 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 229910001923 silver oxide Inorganic materials 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XQGZSYKGWHUSDH-UHFFFAOYSA-N dazoxiben Chemical compound C1=CC(C(=O)O)=CC=C1OCCN1C=NC=C1 XQGZSYKGWHUSDH-UHFFFAOYSA-N 0.000 abstract 1
- 229950008000 dazoxiben Drugs 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 206010025482 malaise Diseases 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to of 2 thienyloxiacetic acide derivatives, espesially to the obtaining of acides of 5-[2-(benzenessilphonylamine)ethyl]- or 5-[2-(4-chlorbenzenesulphonylamine)ethyl]-2 thienyloxiacetics which may be used in medicine for the treatment of thrombotic sickness.The purpose is the creation of new substances with an increasing activity from indicated class. The synthesis is done by the oxidation, for example, of acide amine N-[2-[2-(5-(2-hydroxi)-ethoxi)-thienyl]-ethyl]-benzenesulphone with silock oxide in water-alkaline medium. The amide is dissolved in KOH or NaOH solution with a concentration of 0,5-4n, preferential 2n, oxidizes with 2-16 equivalents of silveroxide at the temperature of 75-85°C during 2-3 hours. Silver oxide initial is obtained preliminarily by dissolving AgNO3 in distilled water and is added equimolar cantities of NaOH. The product with special destination is separated in free form or in shape of salt pharmaceutical useful. The new compounds are a little toxic and 4 times more active than dazoxiben, the beginning of antithrombotic action observing at 1 mg/kg and attains the maximum level of 5 mg/kg against 20 mg/kg.Tab.: 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT82087 | 1987-04-03 | ||
| SU884355476A SU1574176A3 (en) | 1987-04-03 | 1988-04-01 | Method of obtaining derivatives of 2-thienyloxyacetic acid or their pharmaceutically acceptable salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD119B1 MD119B1 (en) | 1994-12-31 |
| MD119C2 true MD119C2 (en) | 1995-07-31 |
Family
ID=25594008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0142A MD119C2 (en) | 1987-04-03 | 1994-04-14 | The method of obtaining of derivatives 2 thienyloxiacetic acide or of salt useful in pharmaceutic |
Country Status (2)
| Country | Link |
|---|---|
| LV (1) | LV5499A3 (en) |
| MD (1) | MD119C2 (en) |
-
1993
- 1993-11-17 LV LV931245A patent/LV5499A3/en unknown
-
1994
- 1994-04-14 MD MD94-0142A patent/MD119C2/en active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| Бюлер К., Пирсон Д., Органические синтезы - М.: Мир, 1973, ч. 2, с. 239 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD119B1 (en) | 1994-12-31 |
| LV5499A3 (en) | 1994-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20080331 |