MA56001A - Formes de sel cristallin d'un inhibiteur de kinase - Google Patents

Formes de sel cristallin d'un inhibiteur de kinase

Info

Publication number
MA56001A
MA56001A MA056001A MA56001A MA56001A MA 56001 A MA56001 A MA 56001A MA 056001 A MA056001 A MA 056001A MA 56001 A MA56001 A MA 56001A MA 56001 A MA56001 A MA 56001A
Authority
MA
Morocco
Prior art keywords
kinase inhibitor
salt forms
crystalline salt
crystalline
forms
Prior art date
Application number
MA056001A
Other languages
English (en)
French (fr)
Inventor
Melanie Janelle Bevill
Frenel Demorin
Courtney S Johnson
Stephan D Parent
Khalid Shah
Sagar Shakya
Peter Wong
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MA56001A publication Critical patent/MA56001A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA056001A 2019-06-03 2019-12-12 Formes de sel cristallin d'un inhibiteur de kinase MA56001A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962856404P 2019-06-03 2019-06-03

Publications (1)

Publication Number Publication Date
MA56001A true MA56001A (fr) 2022-04-06

Family

ID=69160360

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056001A MA56001A (fr) 2019-06-03 2019-12-12 Formes de sel cristallin d'un inhibiteur de kinase

Country Status (22)

Country Link
US (1) US20230052703A1 (enExample)
EP (1) EP3976587B1 (enExample)
JP (1) JP7579281B2 (enExample)
KR (1) KR102826380B1 (enExample)
CN (1) CN113939503B (enExample)
AU (1) AU2019449809B2 (enExample)
BR (1) BR112021024300A2 (enExample)
CA (1) CA3139148A1 (enExample)
CL (1) CL2021003205A1 (enExample)
CO (1) CO2021017343A2 (enExample)
CR (1) CR20210616A (enExample)
DO (1) DOP2021000236A (enExample)
ES (1) ES3008963T3 (enExample)
GE (2) GEP20247655B (enExample)
IL (1) IL288484A (enExample)
MA (1) MA56001A (enExample)
MX (1) MX2021014773A (enExample)
PE (1) PE20220962A1 (enExample)
PH (1) PH12021553020A1 (enExample)
SG (1) SG11202111978VA (enExample)
WO (1) WO2020247019A1 (enExample)
ZA (1) ZA202108034B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117402114A (zh) * 2018-01-26 2024-01-16 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
KR102828472B1 (ko) * 2018-12-13 2025-07-03 엑셀리시스, 인코포레이티드 키나아제 억제제의 결정질 형태 및 염 형태
TW202334090A (zh) * 2021-11-03 2023-09-01 美商艾克塞里克斯公司 用於治療激酶依賴性病症之化合物
US20250368606A1 (en) 2021-12-22 2025-12-04 Exelixis, Inc. Crystalline forms and salt forms of a kinase inhibitor
CN116751161A (zh) * 2023-06-28 2023-09-15 中国人民解放军军事科学院军事医学研究院 喹啉类化合物及其制备方法、药物组合物及医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210607B1 (en) * 2003-09-26 2011-08-17 Exelixis Inc. N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
CA2604238C (en) 2005-04-15 2015-07-07 Neogenix Oncology, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
ES2598530T3 (es) * 2010-07-14 2017-01-27 Betta Pharmaceuticals Co., Ltd. Nuevos derivados heterocíclicos condensados útiles como inhibidores de la tirosina quinasa c-Met
BR112015007672A2 (pt) 2012-10-04 2017-08-08 Dana Farber Cancer Inst Inc anticorpos anti-pd-l1 monoclonais humanos e métodos de uso
SMT202100065T1 (it) 2013-05-02 2021-03-15 Anaptysbio Inc Anticorpi diretti contro la proteina della morte programmata (pd-1)
US20180009758A1 (en) * 2015-06-29 2018-01-11 Ontogenesis, Llc Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use
MA48776A (fr) * 2017-05-26 2020-04-08 Exelixis Inc Formes solides cristallines de sels de n-{4-[(6,7-diméthoxyquinolin-4-yl) oxy]phényl}-n'-(4-fluorphényl) cyclopropane-1,1-dicarboxamide, procédés de préparation et d'utilisation
CN117402114A (zh) * 2018-01-26 2024-01-16 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
KR102828472B1 (ko) * 2018-12-13 2025-07-03 엑셀리시스, 인코포레이티드 키나아제 억제제의 결정질 형태 및 염 형태
CN109761899B (zh) * 2019-02-14 2022-11-15 广州六顺生物科技股份有限公司 喹啉衍生物、其药学上可接受的盐或其溶剂合物、其应用、药物及药物组合物

Also Published As

Publication number Publication date
PH12021553020A1 (en) 2023-08-23
JP7579281B2 (ja) 2024-11-07
ES3008963T3 (en) 2025-03-25
EP3976587A1 (en) 2022-04-06
EP3976587B1 (en) 2024-12-04
BR112021024300A2 (pt) 2022-01-11
AU2019449809B2 (en) 2026-02-05
SG11202111978VA (en) 2021-11-29
CN113939503A (zh) 2022-01-14
CN113939503B (zh) 2024-05-07
IL288484A (en) 2022-01-01
KR102826380B1 (ko) 2025-06-26
AU2019449809A1 (en) 2021-12-16
DOP2021000236A (es) 2022-04-18
CA3139148A1 (en) 2020-12-10
GEAP202415849A (en) 2024-03-11
KR20220016117A (ko) 2022-02-08
PE20220962A1 (es) 2022-06-10
US20230052703A1 (en) 2023-02-16
EP3976587C0 (en) 2024-12-04
JP2022535072A (ja) 2022-08-04
WO2020247019A1 (en) 2020-12-10
CO2021017343A2 (es) 2022-01-17
GEP20247655B (en) 2024-08-26
ZA202108034B (en) 2025-02-26
CR20210616A (es) 2022-03-22
CL2021003205A1 (es) 2022-09-30
MX2021014773A (es) 2022-01-18

Similar Documents

Publication Publication Date Title
MA56001A (fr) Formes de sel cristallin d'un inhibiteur de kinase
MA54458A (fr) Formes cristallines et formes salines d'un inhibiteur de kinase
EP3947361A4 (en) SALT AND CRYSTAL FORM OF A FAK INHIBITOR
EP3924352A4 (en) CRYSTALLINE FORMS OF AN RSK INHIBITOR
MA53226A (fr) Sel et formes cristallines d'omecamtiv mecarbil
EP3870178A4 (en) Crystalline forms of mnk inhibitors
MA52493A (fr) Sels d'un inhibiteur de fgfr
MA55614A (fr) Formes cristallines d'inhibiteur de pyridazinone trpc
MA54526A (fr) NOUVELLES FORMES POLYMORPHES D'UN INHIBITEUR DE TGFBeta
EP3619208C0 (en) CRYSTALLINE FORMS OF A JAK INHIBITOR COMPOUND
SG11202107225SA (en) Crystalline form of a cdk inhibitor
EP3472168A4 (en) CRYSTALLINE FORMS OF A TRIAZOLOPYRIMIDINE COMPOUND
EP3807279A4 (en) PHARMACEUTICALLY ACCEPTABLE SALTS OF SEPIAPTERINE
MA55801A (fr) Formes solides d'un inhibiteur de glyt1
IL289929A (en) Crystal forms of cd73 inhibitor
EP3897660A4 (en) NEW CRYSTALLINE FORMS OF AN NRTTI COMPOUND
EP3873463A4 (en) CRYSTALLINE SALTS OF A PLASMA KALLIKREIN INHIBITOR
EP3829551A4 (en) CRYSTALLINE EPINEPHRIN MALONATE SALT
MA54638A (fr) Formes cristallines d'un stimulateur de sgc
SG11202102110PA (en) Novel hydrochloride salt forms of a sulfonamide structured kinase inhibitor
EP4019496A4 (en) SALT AND CRYSTAL FORM OF A COMPOUND WITH AGONISTIC ACTION ON S1P5 RECEPTOR
EP3996707A4 (en) CRYSTALLINE FORMS OF PLASMACALLICREIN INHIBITORS
MA53561A (fr) Formes cristallines d'un inhibiteur de phosphoinositide 3-kinase (pi3k)
EP3896063A4 (en) SALT INES SYK INHIBITORS AND CRYSTALLINE FORM THEREOF
EP3849964A4 (en) CRYSTALLINE FORMS OF A QUINAZOLE COMPOUND AND ITS HYDROCHLORIDE SALTS