MA54862A - Procédé de préparation d'un agoniste double gip/glp1 - Google Patents

Procédé de préparation d'un agoniste double gip/glp1

Info

Publication number
MA54862A
MA54862A MA054862A MA54862A MA54862A MA 54862 A MA54862 A MA 54862A MA 054862 A MA054862 A MA 054862A MA 54862 A MA54862 A MA 54862A MA 54862 A MA54862 A MA 54862A
Authority
MA
Morocco
Prior art keywords
gip
preparing
dual agonist
glp1 dual
glp1
Prior art date
Application number
MA054862A
Other languages
English (en)
Inventor
Stephanie Ruth Coffin
Michael Oliver Frederick
Ankur Jalan
Neil John Kallman
Michael Eugene Kopach
Kevin Dale Seibert
Sergey Vladimirovich Tsukanov
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA54862A publication Critical patent/MA54862A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/645Secretins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00Purification; Separation; Use of additives
    • C07C7/04Purification; Separation; Use of additives by distillation
    • C07C7/05Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds
    • C07C7/06Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds by azeotropic distillation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Water Supply & Treatment (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA054862A 2019-01-29 2020-01-28 Procédé de préparation d'un agoniste double gip/glp1 MA54862A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962797963P 2019-01-29 2019-01-29
US201962815053P 2019-03-07 2019-03-07
US201962818342P 2019-03-14 2019-03-14

Publications (1)

Publication Number Publication Date
MA54862A true MA54862A (fr) 2022-05-04

Family

ID=69724140

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054862A MA54862A (fr) 2019-01-29 2020-01-28 Procédé de préparation d'un agoniste double gip/glp1

Country Status (18)

Country Link
US (1) US20220135639A1 (fr)
EP (1) EP3917950A1 (fr)
JP (2) JP7315683B2 (fr)
KR (1) KR20210110349A (fr)
CN (1) CN113330024A (fr)
AU (3) AU2020216922A1 (fr)
BR (1) BR112021012368A2 (fr)
CA (2) CA3224820A1 (fr)
CL (1) CL2021001905A1 (fr)
CO (1) CO2021009662A2 (fr)
EC (1) ECSP21056124A (fr)
IL (1) IL284446A (fr)
MA (1) MA54862A (fr)
MX (1) MX2021008965A (fr)
PE (1) PE20211992A1 (fr)
SG (1) SG11202107123TA (fr)
TW (1) TWI799680B (fr)
WO (1) WO2020159949A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110642935A (zh) * 2019-09-25 2020-01-03 成都奥达生物科技有限公司 一种替瑞帕肽类似物
JP2023552362A (ja) * 2020-12-02 2023-12-15 ドンバオ パープル スター (ハンチョウ) バイオファーマシューティカル シーオー.,エルティーディー. ラクタム修飾を含むポリペプチド化合物
EP4281464A1 (fr) * 2021-01-20 2023-11-29 Viking Therapeutics, Inc. Compositions et procédés pour le traitement de troubles métaboliques et hépatiques
WO2022247950A1 (fr) * 2021-05-28 2022-12-01 广东众生睿创生物科技有限公司 Préparation et application de polypeptide
WO2023089594A1 (fr) 2021-11-22 2023-05-25 Sun Pharmaceutical Industries Limited Procédé de préparation de tirzépatide ou de sel pharmaceutiquement acceptable de celui-ci
TW202404996A (zh) 2022-04-04 2024-02-01 美商美國禮來大藥廠 製備glp-1/升糖素雙重促效劑之方法
CN116023444B (zh) * 2022-08-12 2023-08-01 重庆宸安生物制药有限公司 一种gip和glp-1双受体激动剂多肽化合物及其应用
WO2024077149A2 (fr) 2022-10-05 2024-04-11 Eli Lilly And Company Peptides pour la synthèse d'incrétine
WO2024112617A2 (fr) 2022-11-21 2024-05-30 Eli Lilly And Company Procédé de préparation d'un double agoniste gip/glp1
CN116731154A (zh) * 2023-08-14 2023-09-12 苏州金顶生物有限公司 一种全液相法制备替西帕肽的方法
CN117736273B (zh) * 2023-12-08 2024-05-07 广东省卓肽医药有限公司 一种替尔泊肽的纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076066A1 (fr) * 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides abaissant le taux de glucose sanguin
EP2424888A2 (fr) * 2009-05-01 2012-03-07 F. Hoffmann-La Roche AG Synthèse de peptides insulinotropiques à l'aide d'une combinaison de techniques en phase solide et soluble
JOP20200119A1 (ar) 2015-01-09 2017-06-16 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1

Also Published As

Publication number Publication date
SG11202107123TA (en) 2021-08-30
TW202043260A (zh) 2020-12-01
AU2023203001B2 (en) 2024-03-28
TWI799680B (zh) 2023-04-21
CL2021001905A1 (es) 2022-03-11
CN113330024A (zh) 2021-08-31
MX2021008965A (es) 2021-08-24
AU2024201004A1 (en) 2024-03-07
CA3128023A1 (fr) 2020-08-06
PE20211992A1 (es) 2021-10-18
EP3917950A1 (fr) 2021-12-08
JP2023078130A (ja) 2023-06-06
WO2020159949A1 (fr) 2020-08-06
JP2022517834A (ja) 2022-03-10
AU2020216922A1 (en) 2021-07-15
US20220135639A1 (en) 2022-05-05
AU2023203001A1 (en) 2023-06-08
JP7315683B2 (ja) 2023-07-26
CO2021009662A2 (es) 2021-08-09
BR112021012368A2 (pt) 2021-09-14
CA3224820A1 (fr) 2020-08-06
ECSP21056124A (es) 2021-08-31
IL284446A (en) 2021-08-31
KR20210110349A (ko) 2021-09-07

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