MA53898B1 - Dérivés de 4-pyrazin-2-ylméthyl-morpholine et leur utilisation comme médicament - Google Patents

Dérivés de 4-pyrazin-2-ylméthyl-morpholine et leur utilisation comme médicament

Info

Publication number
MA53898B1
MA53898B1 MA53898A MA53898A MA53898B1 MA 53898 B1 MA53898 B1 MA 53898B1 MA 53898 A MA53898 A MA 53898A MA 53898 A MA53898 A MA 53898A MA 53898 B1 MA53898 B1 MA 53898B1
Authority
MA
Morocco
Prior art keywords
pyrazin
ylmethyl
medicine
morpholine derivatives
nr2b
Prior art date
Application number
MA53898A
Other languages
English (en)
Other versions
MA53898A (fr
Inventor
Riccardo Giovannini
Cornelia Dorner-Ciossek
Dieter Wiedenmayer
Angelo Ceci
Roland Pfau
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA53898A publication Critical patent/MA53898A/fr
Publication of MA53898B1 publication Critical patent/MA53898B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

La présente invention concerne de nouvelles 4-pyrazin-2-ylméthyl-morpholines de formule générale a, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie, en particulier dans le traitement ou la prévention d'états associés à des propriétés de modulation allostérique négative de nr2b.
MA53898A 2018-10-17 2019-10-16 Dérivés de 4-pyrazin-2-ylméthyl-morpholine et leur utilisation comme médicament MA53898B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18200943 2018-10-17
PCT/EP2019/078027 WO2020079039A1 (fr) 2018-10-17 2019-10-16 Dérivés de 4-pyrazin-2-ylméthyl-morpholine et leur utilisation en tant que médicament

Publications (2)

Publication Number Publication Date
MA53898A MA53898A (fr) 2022-01-26
MA53898B1 true MA53898B1 (fr) 2023-03-31

Family

ID=63878518

Family Applications (1)

Application Number Title Priority Date Filing Date
MA53898A MA53898B1 (fr) 2018-10-17 2019-10-16 Dérivés de 4-pyrazin-2-ylméthyl-morpholine et leur utilisation comme médicament

Country Status (35)

Country Link
US (2) US11166958B2 (fr)
EP (1) EP3867244B1 (fr)
JP (1) JP7093468B2 (fr)
KR (1) KR20210079325A (fr)
CN (1) CN112888685B (fr)
AR (1) AR116711A1 (fr)
AU (1) AU2019362330B2 (fr)
BR (1) BR112021004993A2 (fr)
CA (1) CA3113308A1 (fr)
CL (1) CL2021000858A1 (fr)
CO (1) CO2021004612A2 (fr)
CR (1) CR20210184A (fr)
DK (1) DK3867244T3 (fr)
DO (1) DOP2021000069A (fr)
EA (1) EA202191014A1 (fr)
EC (1) ECSP21027009A (fr)
ES (1) ES2940184T3 (fr)
FI (1) FI3867244T3 (fr)
HR (1) HRP20230249T1 (fr)
HU (1) HUE061891T2 (fr)
IL (1) IL282142B2 (fr)
JO (1) JOP20210075A1 (fr)
LT (1) LT3867244T (fr)
MA (1) MA53898B1 (fr)
MX (1) MX2021004418A (fr)
PE (1) PE20211278A1 (fr)
PH (1) PH12021550834A1 (fr)
PL (1) PL3867244T3 (fr)
PT (1) PT3867244T (fr)
RS (1) RS63988B1 (fr)
SA (1) SA521421756B1 (fr)
SG (1) SG11202103806VA (fr)
SI (1) SI3867244T1 (fr)
TW (1) TWI828779B (fr)
WO (1) WO2020079039A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113950478B (zh) * 2019-06-04 2024-02-02 勃林格殷格翰国际有限公司 作为nr2b负向调节剂的嘌呤衍生物及其作为药物的用途,特别是用于治疗抑郁病症

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
ES2312603T3 (es) 2001-07-24 2009-03-01 Richter Gedeon Nyrt Derivados de piperidina como antagonistas del receptor nmda.
JP2009518409A (ja) * 2005-12-06 2009-05-07 メルク エンド カムパニー インコーポレーテッド モルホリンカルボキサミドプロキネチシン受容体アンタゴニスト
WO2010088414A2 (fr) * 2009-01-28 2010-08-05 Emory University Potentialisateurs du récepteur nmda, sélectifs pour des sous-unités, et destinés au traitement d'états neurologiques
WO2012128582A2 (fr) 2011-03-23 2012-09-27 Hyundai Pharm Co., Ltd. Composé capable d'inhiber la 11-bêta-hydroxystéroïde déshydrogénase de type 1 humaine et composition pharmaceutique en contenant
EP2909180B1 (fr) 2012-10-18 2016-10-05 F. Hoffmann-La Roche AG Dérivés d'éthynyle comme modulateurs de l'activité des récepteurs mglur5
CN106255679B (zh) * 2014-02-27 2019-09-06 默克专利有限公司 用作nav通道抑制剂的杂环化合物及其用途
WO2016029146A1 (fr) 2014-08-22 2016-02-25 University Of Washington Inhibiteurs spécifiques de la méthionyl-tarn synthétase
US10501451B2 (en) * 2015-10-14 2019-12-10 Bristol-Myers Squibb Company Selective NR2B antagonists

Also Published As

Publication number Publication date
AU2019362330A1 (en) 2021-04-08
JP7093468B2 (ja) 2022-06-29
EA202191014A1 (ru) 2021-11-09
PT3867244T (pt) 2023-02-22
EP3867244B1 (fr) 2023-01-18
SG11202103806VA (en) 2021-05-28
DOP2021000069A (es) 2021-05-31
JOP20210075A1 (ar) 2023-01-30
US11166958B2 (en) 2021-11-09
CN112888685A (zh) 2021-06-01
DK3867244T3 (da) 2023-05-01
CR20210184A (es) 2021-05-26
CN112888685B (zh) 2023-09-22
US20200121691A1 (en) 2020-04-23
TW202031262A (zh) 2020-09-01
CA3113308A1 (fr) 2020-04-23
PH12021550834A1 (en) 2021-10-04
KR20210079325A (ko) 2021-06-29
IL282142A (en) 2021-05-31
PL3867244T3 (pl) 2023-05-22
HRP20230249T1 (hr) 2023-04-14
ECSP21027009A (es) 2021-05-31
SA521421756B1 (ar) 2023-02-12
CL2021000858A1 (es) 2021-10-01
LT3867244T (lt) 2023-03-10
AR116711A1 (es) 2021-06-02
TWI828779B (zh) 2024-01-11
PE20211278A1 (es) 2021-07-19
IL282142B2 (en) 2024-04-01
AU2019362330B2 (en) 2024-03-28
CO2021004612A2 (es) 2021-04-30
US20210393644A1 (en) 2021-12-23
BR112021004993A2 (pt) 2021-06-08
FI3867244T3 (fi) 2023-03-20
JP2022505080A (ja) 2022-01-14
MX2021004418A (es) 2021-07-06
ES2940184T3 (es) 2023-05-04
MA53898A (fr) 2022-01-26
IL282142B1 (en) 2023-12-01
WO2020079039A1 (fr) 2020-04-23
HUE061891T2 (hu) 2023-09-28
SI3867244T1 (sl) 2023-04-28
EP3867244A1 (fr) 2021-08-25
RS63988B1 (sr) 2023-03-31

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