MA47370A - Dérivés bis-hétéroaryliques en tant que modulateurs de l'agrégation des protéines - Google Patents
Dérivés bis-hétéroaryliques en tant que modulateurs de l'agrégation des protéinesInfo
- Publication number
- MA47370A MA47370A MA047370A MA47370A MA47370A MA 47370 A MA47370 A MA 47370A MA 047370 A MA047370 A MA 047370A MA 47370 A MA47370 A MA 47370A MA 47370 A MA47370 A MA 47370A
- Authority
- MA
- Morocco
- Prior art keywords
- heteraryl
- modulators
- bis
- derivatives
- protein aggregation
- Prior art date
Links
- 230000004845 protein aggregation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17153214 | 2017-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA47370A true MA47370A (fr) | 2021-03-24 |
Family
ID=57906527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA047370A MA47370A (fr) | 2017-01-26 | 2018-01-23 | Dérivés bis-hétéroaryliques en tant que modulateurs de l'agrégation des protéines |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10913735B2 (fr) |
| EP (1) | EP3573982B1 (fr) |
| JP (1) | JP7100043B2 (fr) |
| KR (1) | KR20190111080A (fr) |
| CN (1) | CN110198938B (fr) |
| AU (1) | AU2018212436A1 (fr) |
| BR (1) | BR112019011932A2 (fr) |
| CA (1) | CA3048947A1 (fr) |
| CL (1) | CL2019001752A1 (fr) |
| CO (1) | CO2019007835A2 (fr) |
| EA (1) | EA201991756A1 (fr) |
| ES (1) | ES2882285T3 (fr) |
| IL (1) | IL267994A (fr) |
| MA (1) | MA47370A (fr) |
| MX (1) | MX2019007053A (fr) |
| RU (1) | RU2019126170A (fr) |
| WO (1) | WO2018138086A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20161393A1 (es) | 2014-01-29 | 2017-01-08 | Neuropore Therapies Inc | Heteroaril amidas como inhibidores de agregacion de proteina |
| US10975066B2 (en) | 2015-07-29 | 2021-04-13 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| AU2018213886A1 (en) | 2017-01-26 | 2019-07-25 | UCB Biopharma SRL | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| CA3048947A1 (fr) * | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Derives bis-heteroaryliques utilises en tant que modulateurs de l'agregation de proteines |
| CN110167937B (zh) | 2017-01-26 | 2022-03-29 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的二环双-杂芳基衍生物 |
| WO2020041331A1 (fr) | 2018-08-20 | 2020-02-27 | Arvinas Operations, Inc. | Composé chimère ciblant la protéolyse (protac) ayant une activité de liaison à l'ubiquitine ligase e3 et ciblant une protéine alpha-synucléine pour le traitement de maladies neurodégénératives |
| CN109053693B (zh) * | 2018-09-20 | 2021-02-05 | 顺毅股份有限公司 | 哒嗪胺类化合物的制备及其应用 |
| CN118488951A (zh) * | 2021-12-27 | 2024-08-13 | 上海京新生物医药有限公司 | 作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| KR20120112548A (ko) * | 2009-12-16 | 2012-10-11 | 뉴로포레 테라피스, 인코포레이티드 | 시누클레인 병을 치료하는데 적합한 화합물 |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| WO2013134371A1 (fr) | 2012-03-06 | 2013-09-12 | Neuropore Therapies, Inc. | Procédés et composés pouvant être utilisés pour traiter les maladies neurodégénératives |
| NZ631388A (en) | 2012-03-28 | 2016-01-29 | Neuropore Therapies Inc | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| CA2877983A1 (fr) | 2012-07-16 | 2014-01-23 | Neuropore Therapies, Inc. | Derives di- et tri-heteroaryle utilises comme inhibiteurs de l'agregation de proteines |
| PE20161393A1 (es) | 2014-01-29 | 2017-01-08 | Neuropore Therapies Inc | Heteroaril amidas como inhibidores de agregacion de proteina |
| US10975066B2 (en) | 2015-07-29 | 2021-04-13 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| AU2018213886A1 (en) * | 2017-01-26 | 2019-07-25 | UCB Biopharma SRL | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| CA3048947A1 (fr) * | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Derives bis-heteroaryliques utilises en tant que modulateurs de l'agregation de proteines |
| CN110167937B (zh) * | 2017-01-26 | 2022-03-29 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的二环双-杂芳基衍生物 |
-
2018
- 2018-01-23 CA CA3048947A patent/CA3048947A1/fr active Pending
- 2018-01-23 KR KR1020197024619A patent/KR20190111080A/ko not_active Application Discontinuation
- 2018-01-23 JP JP2019539746A patent/JP7100043B2/ja active Active
- 2018-01-23 MA MA047370A patent/MA47370A/fr unknown
- 2018-01-23 ES ES18703236T patent/ES2882285T3/es active Active
- 2018-01-23 MX MX2019007053A patent/MX2019007053A/es unknown
- 2018-01-23 WO PCT/EP2018/051580 patent/WO2018138086A1/fr unknown
- 2018-01-23 EA EA201991756A patent/EA201991756A1/ru unknown
- 2018-01-23 EP EP18703236.2A patent/EP3573982B1/fr active Active
- 2018-01-23 AU AU2018212436A patent/AU2018212436A1/en not_active Abandoned
- 2018-01-23 BR BR112019011932-9A patent/BR112019011932A2/pt not_active Application Discontinuation
- 2018-01-23 CN CN201880007816.3A patent/CN110198938B/zh active Active
- 2018-01-23 US US16/480,252 patent/US10913735B2/en active Active
- 2018-01-23 RU RU2019126170A patent/RU2019126170A/ru not_active Application Discontinuation
-
2019
- 2019-06-21 CL CL2019001752A patent/CL2019001752A1/es unknown
- 2019-07-11 IL IL267994A patent/IL267994A/en unknown
- 2019-07-22 CO CONC2019/0007835A patent/CO2019007835A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019126170A (ru) | 2021-02-26 |
| IL267994A (en) | 2019-09-26 |
| BR112019011932A2 (pt) | 2019-10-29 |
| WO2018138086A1 (fr) | 2018-08-02 |
| CN110198938B (zh) | 2023-03-14 |
| AU2018212436A1 (en) | 2019-07-25 |
| EP3573982A1 (fr) | 2019-12-04 |
| KR20190111080A (ko) | 2019-10-01 |
| US10913735B2 (en) | 2021-02-09 |
| CN110198938A (zh) | 2019-09-03 |
| CO2019007835A2 (es) | 2019-07-31 |
| JP7100043B2 (ja) | 2022-07-12 |
| MX2019007053A (es) | 2019-08-29 |
| JP2020505372A (ja) | 2020-02-20 |
| ES2882285T3 (es) | 2021-12-01 |
| EP3573982B1 (fr) | 2021-06-16 |
| US20190367502A1 (en) | 2019-12-05 |
| CL2019001752A1 (es) | 2019-11-22 |
| CA3048947A1 (fr) | 2018-08-02 |
| EA201991756A1 (ru) | 2020-01-23 |
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