MA42685A - Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation - Google Patents

Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation

Info

Publication number
MA42685A
MA42685A MA042685A MA42685A MA42685A MA 42685 A MA42685 A MA 42685A MA 042685 A MA042685 A MA 042685A MA 42685 A MA42685 A MA 42685A MA 42685 A MA42685 A MA 42685A
Authority
MA
Morocco
Prior art keywords
hydrochloride
dextromethadone
synthesis
methods
levomethadone
Prior art date
Application number
MA042685A
Other languages
English (en)
Inventor
Gnel Mkrtchyan
Qingwei Yao
Original Assignee
Cody Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cody Laboratories Inc filed Critical Cody Laboratories Inc
Publication of MA42685A publication Critical patent/MA42685A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA042685A 2015-08-24 2016-08-24 Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation MA42685A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562209168P 2015-08-24 2015-08-24

Publications (1)

Publication Number Publication Date
MA42685A true MA42685A (fr) 2018-07-04

Family

ID=56853854

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042685A MA42685A (fr) 2015-08-24 2016-08-24 Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation

Country Status (5)

Country Link
US (2) US10040752B2 (fr)
EP (1) EP3341354A1 (fr)
CN (1) CN108137483A (fr)
MA (1) MA42685A (fr)
WO (1) WO2017035224A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10040752B2 (en) * 2015-08-24 2018-08-07 Cody Laboratories, Inc. Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
US20180214395A1 (en) * 2017-01-31 2018-08-02 Paolo L. Manfredi Compounds for Treatment or Prevention of Disorders of the Nervous System and Symptoms and Manifestations Thereof, and for Cyto-Protection Against Diseases and Aging of Cells, and Symptoms and Manifestations Thereof
CN108693272B (zh) * 2018-06-04 2021-03-12 吉林百纯化学科技有限公司 一种hplc法分析及制备n-（对甲苯磺酰基）-l-丙氨酸及其对映异构体的方法
US20200033307A1 (en) * 2018-07-25 2020-01-30 Honeywell International Inc. Method of determining an amount of water in a sample using a derivative of imidazole and a hydrogen halide donor
US11332434B2 (en) * 2019-04-17 2022-05-17 Javad Safaei-Ghomi Synthesis of levomethadone hydrochloride
CN110818908B (zh) * 2019-08-29 2021-12-17 杭州市富阳区浙工大银湖创新创业研究院 一种用于检测氧化气体的金属有机骨架材料的制备方法
JP2024514316A (ja) * 2021-04-09 2024-04-01 パオロ エル マンフレディ エナンチオ純粋な（ｓ）－メサドン、（ｒ）－メサドン、ラセミ（ｒ，ｓ）－メサドン、及び関連類似体物質を合成するための新規方法
CA3224723A1 (fr) * 2021-06-30 2023-01-05 Paolo L. Manfredi Formulations a liberation modifiee de methadone et ses isomeres, d'esmethadone et de levomethadone et derives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2540636A (en) 1947-11-12 1951-02-06 Mallinckrodt Chemical Works Separation of nitrile intermediates in amidone synthesis
US2497739A (en) 1949-01-05 1950-02-14 Merck & Co Inc Process of separating isomers of amidone intermediates
US2601323A (en) 1949-02-02 1952-06-24 Upjohn Co Process for preparing 4, 4-diphenyl-6-dimethylamino-heptanone-3
GB1124682A (en) 1966-06-21 1968-08-21 Wyeth John & Brother Ltd Preparation of amines
US4048211A (en) 1976-05-10 1977-09-13 Eli Lilly And Company Modification of methadone synthesis process step
US4242274A (en) 1979-06-18 1980-12-30 Mallinckrodt, Inc. Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile
GB9611041D0 (en) 1996-05-25 1996-07-31 Salford Ultrafine Chem & Res Process for the preparation of optically active methadones in high enantiomeric purity
SK287446B6 (sk) 2007-02-08 2010-10-07 Zentiva, A. S. Spôsob prípravy metadóniumchloridu
US10533000B2 (en) 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof
MY183354A (en) 2011-11-22 2021-02-18 Univ Sains Malaysia (r)-6-(dimthylamino)-4,4-diphenylheptan-3-one
US9468611B2 (en) 2012-09-27 2016-10-18 Relmada Therapeutics, Inc. d-Methadone for the treatment of psychiatric symptoms
US10040752B2 (en) * 2015-08-24 2018-08-07 Cody Laboratories, Inc. Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

Also Published As

Publication number Publication date
CN108137483A (zh) 2018-06-08
US20170057909A1 (en) 2017-03-02
WO2017035224A1 (fr) 2017-03-02
US10040752B2 (en) 2018-08-07
EP3341354A1 (fr) 2018-07-04
US20190002394A1 (en) 2019-01-03

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