MA28547B1 - Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte - Google Patents

Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte

Info

Publication number
MA28547B1
MA28547B1 MA29405A MA29405A MA28547B1 MA 28547 B1 MA28547 B1 MA 28547B1 MA 29405 A MA29405 A MA 29405A MA 29405 A MA29405 A MA 29405A MA 28547 B1 MA28547 B1 MA 28547B1
Authority
MA
Morocco
Prior art keywords
mastocyte
tryptase
thiophen
piperidin
aminomethyl
Prior art date
Application number
MA29405A
Other languages
English (en)
French (fr)
Inventor
Zhongli Gao
Larry Davis
Julian Levell
Mark Czekaj
Adam W Sledeski
El-Bdaoui Haddad
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MA28547B1 publication Critical patent/MA28547B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA29405A 2004-03-26 2006-10-20 Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte MA28547B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55692704P 2004-03-26 2004-03-26

Publications (1)

Publication Number Publication Date
MA28547B1 true MA28547B1 (fr) 2007-04-03

Family

ID=34964263

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29405A MA28547B1 (fr) 2004-03-26 2006-10-20 Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte

Country Status (25)

Country Link
US (1) US20070142435A1 (https=)
EP (1) EP1737848A1 (https=)
JP (1) JP2007530580A (https=)
KR (1) KR20060130682A (https=)
CN (1) CN1956978A (https=)
AR (1) AR048336A1 (https=)
AU (1) AU2005230934A1 (https=)
BR (1) BRPI0509245A (https=)
CA (1) CA2560649A1 (https=)
CR (1) CR8603A (https=)
DO (1) DOP2005000039A (https=)
EC (1) ECSP066878A (https=)
IL (1) IL178031A0 (https=)
MA (1) MA28547B1 (https=)
MX (1) MXPA06010610A (https=)
NO (1) NO20064811L (https=)
PA (1) PA8627601A1 (https=)
PE (1) PE20060084A1 (https=)
RU (1) RU2330034C1 (https=)
TN (1) TNSN06278A1 (https=)
TW (1) TW200602035A (https=)
UA (1) UA83738C2 (https=)
UY (1) UY28821A1 (https=)
WO (1) WO2005097780A1 (https=)
ZA (1) ZA200607752B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20071148A1 (es) * 2006-03-29 2007-12-10 Sanofi Aventis Mejoras en la preparacion de intermedios que conducen a hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona
AR065616A1 (es) * 2007-03-07 2009-06-17 Sanofi Aventis Sintesis regioselectiva de ullmann de acido 4- bromo-3- metil-5- propoxi- tiofeno-2- carboxilico
WO2008115912A1 (en) * 2007-03-21 2008-09-25 Sanofi-Aventis Regio-specific synthesis of 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid
AR065859A1 (es) * 2007-03-29 2009-07-08 Sanofi Aventis Ester de 2,5-dioxo-pirrolidin-1-ilo de acido 4-bromo-3-metil-5-propoxitiofen-2- carboxilico ,su sintesis regioespecifica y un intermedio del mismo
AR065858A1 (es) * 2007-03-29 2009-07-08 Sanofi Aventis Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona.
ES2469824T3 (es) * 2007-11-21 2014-06-20 Janssen Pharmaceutica N.V. Espiropiperidinas para su uso como inhibidores de la triptasa
NZ587119A (en) * 2008-01-24 2013-01-25 Soligenix Inc Use of beclomethasone dipropionate in the treatment of an interstitial lung disease
CN102149705B (zh) * 2008-08-22 2013-08-07 赛诺菲-安万特 作为肥大细胞类胰蛋白酶抑制剂的[4-(5-氨基甲基-2-氟苯基)-哌啶-1-基]-[7-氟-1-(2-甲氧基乙基)-4-三氟甲氧基-1h-吲哚-3-基]-甲酮
TW201034675A (en) 2008-12-18 2010-10-01 Sanofi Aventis Method for treating macular degeneration
FR2955324A1 (fr) * 2010-01-15 2011-07-22 Sanofi Aventis [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees
EP2483243B1 (en) 2009-09-24 2015-03-18 Sanofi-Aventis U.S. LLC Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof
CA2784894A1 (en) * 2009-12-23 2011-06-30 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
EP2516428A1 (en) * 2009-12-23 2012-10-31 Sanofi Tropinone benzylamines as beta-tryptase inhibitors
AU2010333892A1 (en) * 2009-12-23 2012-07-19 Sanofi Treatment for inflammatory bowel disease
AU2011220909A1 (en) * 2010-02-24 2012-09-13 Sanofi Treatment of dermatological allergic conditions
PL2763979T3 (pl) 2011-10-07 2019-06-28 Takeda Pharmaceutical Company Limited Związki 1-arylokarbonyl-4-oksy-piperydynowe użyteczne do leczenia chorób neurodegeneracyjnych
PE20191548A1 (es) * 2017-02-10 2019-10-24 Genentech Inc Anticuerpos contra triptasa, composiciones de estos y usos de estos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
DZ3347A1 (fr) * 2000-05-22 2001-11-29 Aventis Pharma Inc Dérivés d'arylméthylamine pour leur utilisation comme inhibiteurs de la tryptase

Also Published As

Publication number Publication date
RU2006137717A (ru) 2008-05-10
EP1737848A1 (en) 2007-01-03
AR048336A1 (es) 2006-04-19
JP2007530580A (ja) 2007-11-01
PE20060084A1 (es) 2006-03-09
UA83738C2 (en) 2008-08-11
TW200602035A (en) 2006-01-16
WO2005097780A1 (en) 2005-10-20
ECSP066878A (es) 2006-11-24
US20070142435A1 (en) 2007-06-21
KR20060130682A (ko) 2006-12-19
PA8627601A1 (es) 2006-01-23
CN1956978A (zh) 2007-05-02
NO20064811L (no) 2006-10-23
RU2330034C1 (ru) 2008-07-27
CR8603A (es) 2007-06-08
CA2560649A1 (en) 2005-10-20
UY28821A1 (es) 2005-10-31
BRPI0509245A (pt) 2007-09-11
MXPA06010610A (es) 2006-12-15
ZA200607752B (en) 2008-05-28
IL178031A0 (en) 2006-12-31
AU2005230934A1 (en) 2005-10-20
TNSN06278A1 (en) 2007-12-03
DOP2005000039A (es) 2005-10-31

Similar Documents

Publication Publication Date Title
MA28547B1 (fr) Chlorhydrate de [4-(5-aminomethyl-2-fluoro-phenyl)- piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone en tant qu'inhibiteur de tryptase de mastocyte
ATE448217T1 (de) Substituierte piperidine als renin-inhibitoren
NO2018020I1 (no) Obinutuzumab
MA28631B1 (fr) Antagonistes des recepteurs muscariniques de l'acetylcholine
ATE461191T1 (de) N-substituierte 2-oxodihydropyridinderivate als npy antagonisten
DE60320933D1 (de) Rho-kinase inhibitoren
ATE441641T1 (de) Isochinolinderivate als inhibitoren von rho- kinase
DE602005020465D1 (de) Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer
DK1811959T4 (da) Oftalmiske sammensætninger
DE602005016159D1 (de) Heterozyklische aspartyl-proteasehemmer
FI20050721A0 (fi) Hakkeen jauhatus
ATE521595T1 (de) Cyclohexylaminisochinolonderivate als rho-kinase- inhibitor
EP1801194A4 (en) LAUNDRY DETERGENT
DK2783682T3 (da) Farmaceutisk sammensætning omfattende pimobendan
MA28801B1 (fr) Composition antihistaminique
DE602005015394D1 (de) Schlagwerkzeug
IL180329A0 (en) Piperidine derivatives as nk1 antagonists
ATE370135T1 (de) Substituierte piperidine als histamin-h3- rezeptorliganden
DE602005023034D1 (de) Fleckenreiniger
AT503311A3 (de) Vertikale mikrospritzgiessmaschine
DE602004006997D1 (de) 4-(aminomethyl)-piperidinbenzamide als 5ht4 -antagonisten
MA28363A1 (fr) Antagonistes des recepteurs muscariniques de l'acetylcholine
MA28602B1 (fr) Pyridin-4-yl-ethynyl-imidazoles et pyrazoles en tant qu'antagonistes des recepteurs mglur5
DE602004000307D1 (de) Seifenzusammensetzung in Schmelzblockform
ATE441647T1 (de) N-amidderivate von 8-azabicycloä3.2.1üoct-3-yl als ccr1-antagonisten