LV13089B - 4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents - Google Patents

4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents Download PDF

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Publication number
LV13089B
LV13089B LVP-03-63A LV030063A LV13089B LV 13089 B LV13089 B LV 13089B LV 030063 A LV030063 A LV 030063A LV 13089 B LV13089 B LV 13089B
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LV
Latvia
Prior art keywords
alkyl
imidazo
aryl
fluoro
compound
Prior art date
Application number
LVP-03-63A
Other languages
English (en)
Inventor
Sharon N Bisaha
Ronald B Gammill
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of LV13089B publication Critical patent/LV13089B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Claims (8)

  1. LV 13089 IZGUDROJUMA FORMULA 1. Savienojums ar formulu (I)
    20 kur R1f R2 un R4 neatkarīgi ir H, F, Cl, Br, CF3, C^alkilgrupa, CN, OH, OC^alkilgrupa, -OCO-C^alkilgrupa vai N(R9)2; R5 un R6 neatkarīgi ir H, Ct.8alkilgrupa, OH, CF3, OCO-C^alkilgrupa vai OCO-C612arilgrupa, vai R5 un R6 kopā ir =0; R7 ir H, F, Cl, Br, I, CN, CF3, C^alkilgrupa, -CH2CH2CF3 vai 25 ciklopropilgrupa; R9 ir neatkarīgi H, C^alkilgrupa, C6.12arilgrupa, C^alkil-Cg^arilgrupa, C1.6alkil-C6.12heteroarilgrupa, -C(0)R8, -C(0)N(R8)2 vai -(CH2)M-N(R8)2 un R8 ir C^alkilgrupa, C6.12arilgrupa, C1.6alkil-C8.12arilgrupa vai 30 C^alkil-heteroCg.^arilgrupa vai divi R8 var tikt ņemti kopā, lai veidotu ciklisku sistēmu, kas papildus norādītajam slāpekļa atomam satur kādu citu heteroatomu, proti sēru, skābekli vai NRg; vai tā farmaceitiski pieņemams sāls. 35
  2. 2. Savienojums saskaņā ar 1. punktu, kur Q ir (A).
  3. 3. Savienojums saskaņā ar 1. vai 2. punktu, kur R1f R2 un R4 katrs ir H. 2
  4. 4. Savienojums saskaņā ar jebkuru no iepriekšējiem punktiem, kur R5 un R6 katrs ir H.
  5. 5. Savienojums saskaņā ar 1. punktu, kas ir 5 etil-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-karboksilāts; terobutil-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-karboksilāts; terc-butil-6-ciano-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-kar-boksilāts vai 10 3-(5-ciklopropil-1,2,4-oksadiazol-3-il)-7-fluor-4H-imidazo(5,1 -c)(1,4)- benzoksazīns.
  6. 6. Savienojuma saskaņā ar jebkuru no iepriekšējiem punktiem izmantošana medikamenta pagatavošanai, kas izmantojams ar benzodiazepina 15 receptoriem saistītu centrālās nervu sistēmas traucējumu ārstēšanā.
  7. 7. Farmaceitiska kompozīcija ar benzodiazepina receptoriem saistītu centrālās nervu sistēmas traucējumu ārstēšanai, kas satur savienojumu saskaņā ar jebkuru punktu no 1. līdz 5. punktam un farmaceitiski 20 pieņemamu nesēju vai atšķaidītāju.
  8. 8. Kompozīcija saskaņā ar 7. punktu, kurā savienojums ir daudzumā no 10 līdz 100 mg.
LVP-03-63A 1992-02-13 2003-06-12 4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents LV13089B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83664592A 1992-02-13 1992-02-13

Publications (1)

Publication Number Publication Date
LV13089B true LV13089B (en) 2004-01-20

Family

ID=25272407

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-03-63A LV13089B (en) 1992-02-13 2003-06-12 4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents

Country Status (11)

Country Link
US (1) US5610158A (lv)
EP (1) EP0625982B1 (lv)
JP (1) JP3512110B2 (lv)
AT (1) ATE219083T1 (lv)
AU (1) AU3443593A (lv)
DE (1) DE69332019T2 (lv)
DK (1) DK0625982T3 (lv)
ES (1) ES2177539T3 (lv)
LV (1) LV13089B (lv)
PT (1) PT625982E (lv)
WO (1) WO1993016082A1 (lv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9410469D0 (en) * 1994-05-25 1994-07-13 Erba Farmitalia Imidazolylalkyl derivatives of imidazo (5,1-c) (1,4) benzoxazin-1-one and process for their preparation
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
MX2008009475A (es) * 2006-01-23 2008-10-20 Amira Pharmaceuticals Inc Inhibidores triciclicos de 5-lipoxigenasa.
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
TWI546305B (zh) 2011-01-10 2016-08-21 英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
CN105658650B (zh) * 2013-06-24 2019-01-08 默克专利有限公司 用作卵泡刺激素受体调节剂的咪唑化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1052009B (it) * 1975-12-30 1981-06-20 Erba Carlo Spa Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati
GB2043637B (en) * 1979-02-09 1983-03-16 Roussel Lab Ltd Heterotricyclic derivatives
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK160876C (da) * 1987-12-08 1991-10-14 Novo Nordisk As Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar

Also Published As

Publication number Publication date
AU3443593A (en) 1993-09-03
DE69332019T2 (de) 2002-11-28
JP3512110B2 (ja) 2004-03-29
DE69332019D1 (de) 2002-07-18
PT625982E (pt) 2002-10-31
WO1993016082A1 (en) 1993-08-19
EP0625982B1 (en) 2002-06-12
ATE219083T1 (de) 2002-06-15
JPH07503727A (ja) 1995-04-20
EP0625982A1 (en) 1994-11-30
US5610158A (en) 1997-03-11
ES2177539T3 (es) 2002-12-16
DK0625982T3 (da) 2002-09-30

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