LV13089B - 4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents - Google Patents
4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents Download PDFInfo
- Publication number
- LV13089B LV13089B LVP-03-63A LV030063A LV13089B LV 13089 B LV13089 B LV 13089B LV 030063 A LV030063 A LV 030063A LV 13089 B LV13089 B LV 13089B
- Authority
- LV
- Latvia
- Prior art keywords
- alkyl
- imidazo
- aryl
- fluoro
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Adhesives Or Adhesive Processes (AREA)
Claims (8)
- LV 13089 IZGUDROJUMA FORMULA 1. Savienojums ar formulu (I)20 kur R1f R2 un R4 neatkarīgi ir H, F, Cl, Br, CF3, C^alkilgrupa, CN, OH, OC^alkilgrupa, -OCO-C^alkilgrupa vai N(R9)2; R5 un R6 neatkarīgi ir H, Ct.8alkilgrupa, OH, CF3, OCO-C^alkilgrupa vai OCO-C612arilgrupa, vai R5 un R6 kopā ir =0; R7 ir H, F, Cl, Br, I, CN, CF3, C^alkilgrupa, -CH2CH2CF3 vai 25 ciklopropilgrupa; R9 ir neatkarīgi H, C^alkilgrupa, C6.12arilgrupa, C^alkil-Cg^arilgrupa, C1.6alkil-C6.12heteroarilgrupa, -C(0)R8, -C(0)N(R8)2 vai -(CH2)M-N(R8)2 un R8 ir C^alkilgrupa, C6.12arilgrupa, C1.6alkil-C8.12arilgrupa vai 30 C^alkil-heteroCg.^arilgrupa vai divi R8 var tikt ņemti kopā, lai veidotu ciklisku sistēmu, kas papildus norādītajam slāpekļa atomam satur kādu citu heteroatomu, proti sēru, skābekli vai NRg; vai tā farmaceitiski pieņemams sāls. 35
- 2. Savienojums saskaņā ar 1. punktu, kur Q ir (A).
- 3. Savienojums saskaņā ar 1. vai 2. punktu, kur R1f R2 un R4 katrs ir H. 2
- 4. Savienojums saskaņā ar jebkuru no iepriekšējiem punktiem, kur R5 un R6 katrs ir H.
- 5. Savienojums saskaņā ar 1. punktu, kas ir 5 etil-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-karboksilāts; terobutil-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-karboksilāts; terc-butil-6-ciano-7-fluor-4H-imidazo(5,1-c)(1,4)benzoksazīn-3-kar-boksilāts vai 10 3-(5-ciklopropil-1,2,4-oksadiazol-3-il)-7-fluor-4H-imidazo(5,1 -c)(1,4)- benzoksazīns.
- 6. Savienojuma saskaņā ar jebkuru no iepriekšējiem punktiem izmantošana medikamenta pagatavošanai, kas izmantojams ar benzodiazepina 15 receptoriem saistītu centrālās nervu sistēmas traucējumu ārstēšanā.
- 7. Farmaceitiska kompozīcija ar benzodiazepina receptoriem saistītu centrālās nervu sistēmas traucējumu ārstēšanai, kas satur savienojumu saskaņā ar jebkuru punktu no 1. līdz 5. punktam un farmaceitiski 20 pieņemamu nesēju vai atšķaidītāju.
- 8. Kompozīcija saskaņā ar 7. punktu, kurā savienojums ir daudzumā no 10 līdz 100 mg.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83664592A | 1992-02-13 | 1992-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
LV13089B true LV13089B (en) | 2004-01-20 |
Family
ID=25272407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-03-63A LV13089B (en) | 1992-02-13 | 2003-06-12 | 4-oxo-and 4h-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents |
Country Status (11)
Country | Link |
---|---|
US (1) | US5610158A (lv) |
EP (1) | EP0625982B1 (lv) |
JP (1) | JP3512110B2 (lv) |
AT (1) | ATE219083T1 (lv) |
AU (1) | AU3443593A (lv) |
DE (1) | DE69332019T2 (lv) |
DK (1) | DK0625982T3 (lv) |
ES (1) | ES2177539T3 (lv) |
LV (1) | LV13089B (lv) |
PT (1) | PT625982E (lv) |
WO (1) | WO1993016082A1 (lv) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9410469D0 (en) * | 1994-05-25 | 1994-07-13 | Erba Farmitalia | Imidazolylalkyl derivatives of imidazo (5,1-c) (1,4) benzoxazin-1-one and process for their preparation |
ZA968661B (en) * | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
MX2008009475A (es) * | 2006-01-23 | 2008-10-20 | Amira Pharmaceuticals Inc | Inhibidores triciclicos de 5-lipoxigenasa. |
CU20090172A7 (es) | 2009-10-09 | 2011-10-05 | Ct De Investigación Y Desarrollo De Medicamentos | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
TWI546305B (zh) | 2011-01-10 | 2016-08-21 | 英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
CN105658650B (zh) * | 2013-06-24 | 2019-01-08 | 默克专利有限公司 | 用作卵泡刺激素受体调节剂的咪唑化合物及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1052009B (it) * | 1975-12-30 | 1981-06-20 | Erba Carlo Spa | Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati |
GB2043637B (en) * | 1979-02-09 | 1983-03-16 | Roussel Lab Ltd | Heterotricyclic derivatives |
DK476885D0 (da) * | 1985-10-17 | 1985-10-17 | Ferrosan As | Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf |
DK155524C (da) * | 1987-03-18 | 1989-09-11 | Ferrosan As | Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse |
DK160876C (da) * | 1987-12-08 | 1991-10-14 | Novo Nordisk As | Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar |
-
1993
- 1993-01-14 DE DE69332019T patent/DE69332019T2/de not_active Expired - Fee Related
- 1993-01-14 DK DK93902972T patent/DK0625982T3/da active
- 1993-01-14 ES ES93902972T patent/ES2177539T3/es not_active Expired - Lifetime
- 1993-01-14 WO PCT/US1993/000095 patent/WO1993016082A1/en active IP Right Grant
- 1993-01-14 EP EP93902972A patent/EP0625982B1/en not_active Expired - Lifetime
- 1993-01-14 AT AT93902972T patent/ATE219083T1/de not_active IP Right Cessation
- 1993-01-14 JP JP51405293A patent/JP3512110B2/ja not_active Expired - Fee Related
- 1993-01-14 AU AU34435/93A patent/AU3443593A/en not_active Abandoned
- 1993-01-14 PT PT93902972T patent/PT625982E/pt unknown
-
1994
- 1994-08-03 US US08/285,560 patent/US5610158A/en not_active Expired - Fee Related
-
2003
- 2003-06-12 LV LVP-03-63A patent/LV13089B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU3443593A (en) | 1993-09-03 |
DE69332019T2 (de) | 2002-11-28 |
JP3512110B2 (ja) | 2004-03-29 |
DE69332019D1 (de) | 2002-07-18 |
PT625982E (pt) | 2002-10-31 |
WO1993016082A1 (en) | 1993-08-19 |
EP0625982B1 (en) | 2002-06-12 |
ATE219083T1 (de) | 2002-06-15 |
JPH07503727A (ja) | 1995-04-20 |
EP0625982A1 (en) | 1994-11-30 |
US5610158A (en) | 1997-03-11 |
ES2177539T3 (es) | 2002-12-16 |
DK0625982T3 (da) | 2002-09-30 |
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