LV12374A - (4R, 5S, 6S, 7R) -Hexahydro-1- (5- (3-aminoindazole) methyl) -3-butyl-5,6-dioxo-4,7-bis (phenylmethyl) -2H-1,3- obtaining the diazepin-2-one compound and the use of an HIV protease inhibitor - Google Patents

(4R, 5S, 6S, 7R) -Hexahydro-1- (5- (3-aminoindazole) methyl) -3-butyl-5,6-dioxo-4,7-bis (phenylmethyl) -2H-1,3- obtaining the diazepin-2-one compound and the use of an HIV protease inhibitor

Info

Publication number
LV12374A
LV12374A LV990075A LV990075A LV12374A LV 12374 A LV12374 A LV 12374A LV 990075 A LV990075 A LV 990075A LV 990075 A LV990075 A LV 990075A LV 12374 A LV12374 A LV 12374A
Authority
LV
Latvia
Prior art keywords
hiv protease
aminoindazole
diazepin
phenylmethyl
hexahydro
Prior art date
Application number
LV990075A
Other languages
Latvian (lv)
Other versions
LV12374B (en
Inventor
James David Rodgers
Patrick Lam
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of LV12374A publication Critical patent/LV12374A/en
Publication of LV12374B publication Critical patent/LV12374B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
LVP-99-75A 1996-11-08 1999-04-29 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoindazole)methyl]-3-butyl-5,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor LV12374B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number Publication Date
LV12374A true LV12374A (en) 1999-11-20
LV12374B LV12374B (en) 2000-04-20

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-75A LV12374B (en) 1996-11-08 1999-04-29 (4r,5s,6s,7r)-hexahydro-1-[5-(3-aminoindazole)methyl]-3-butyl-5,6-dihydroxy-4,7-bis[phaenylmethyl]-2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (en)
JP (1) JP2001503429A (en)
KR (1) KR20000053123A (en)
CN (1) CN1235601A (en)
AU (1) AU722489B2 (en)
BR (1) BR9712755A (en)
CA (1) CA2270963A1 (en)
CZ (1) CZ157499A3 (en)
EA (1) EA001154B1 (en)
EE (1) EE9900187A (en)
HU (1) HUP9904143A3 (en)
IL (1) IL129726A0 (en)
LV (1) LV12374B (en)
NO (1) NO992229L (en)
NZ (1) NZ335919A (en)
PL (1) PL333412A1 (en)
SI (1) SI9720071A (en)
SK (1) SK59599A3 (en)
WO (1) WO1998020009A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6870098A (en) * 1997-03-31 1998-10-22 Du Pont Merck Pharmaceutical Company, The Indazoles of cyclic ureas useful as hiv protease inhibitors
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (en) 2000-06-13 2007-05-25 Centre Nat Rech Scient CYCLIC UREA COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
EP0765873B1 (en) * 1991-10-11 2002-04-17 Dupont Pharmaceuticals Company Cyclic ureas and analogues useful as retroviral protease inhibitors

Also Published As

Publication number Publication date
EA001154B1 (en) 2000-10-30
EP0937066A1 (en) 1999-08-25
KR20000053123A (en) 2000-08-25
IL129726A0 (en) 2000-02-29
EA199900451A1 (en) 1999-12-29
BR9712755A (en) 1999-10-19
JP2001503429A (en) 2001-03-13
CN1235601A (en) 1999-11-17
CZ157499A3 (en) 1999-11-17
CA2270963A1 (en) 1998-05-14
NO992229L (en) 1999-06-07
SK59599A3 (en) 1999-12-10
AU5103398A (en) 1998-05-29
WO1998020009A1 (en) 1998-05-14
HUP9904143A3 (en) 2002-11-28
AU722489B2 (en) 2000-08-03
LV12374B (en) 2000-04-20
PL333412A1 (en) 1999-12-06
HUP9904143A2 (en) 2000-06-28
SI9720071A (en) 1999-12-31
NO992229D0 (en) 1999-05-07
EE9900187A (en) 1999-12-15
NZ335919A (en) 2000-09-29

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