HUP9904143A2 - (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2h-1,3-diazepin-2-one,its preparation and its use as hiv protease inhibitor - Google Patents

(4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2h-1,3-diazepin-2-one,its preparation and its use as hiv protease inhibitor

Info

Publication number
HUP9904143A2
HUP9904143A2 HU9904143A HUP9904143A HUP9904143A2 HU P9904143 A2 HUP9904143 A2 HU P9904143A2 HU 9904143 A HU9904143 A HU 9904143A HU P9904143 A HUP9904143 A HU P9904143A HU P9904143 A2 HUP9904143 A2 HU P9904143A2
Authority
HU
Hungary
Prior art keywords
hiv protease
aminoinazole
diazepin
phenylmethyl
hexahydro
Prior art date
Application number
HU9904143A
Other languages
Hungarian (hu)
Inventor
Patrick Yuk-Sun Lam
James David Rodgers
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of HUP9904143A2 publication Critical patent/HUP9904143A2/en
Publication of HUP9904143A3 publication Critical patent/HUP9904143A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány (I) képletű vegyületre vagy annak gyógyászatilagelfőgadható sóira, ill. prő-drőgjaira vőnatkőzik, amelyekfelhasználhatók HIV-prőteáz-inhibitőrként. A találmány vőnatkőziktővábbá az ezeket tartalmazó gyógyászati készítményekre ésdiagnősztikai készletekre is. ŕThe invention applies to the compound of formula (I) or its medicinally soluble salts, or It focuses on its prodrugs, which can be used as HIV protease inhibitors. The invention also extends to medicinal preparations and diagnostic kits containing them. ŕ

HU9904143A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2h-1,3-diazepin-2-one,its preparation and its use as hiv protease inhibitor HUP9904143A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number Publication Date
HUP9904143A2 true HUP9904143A2 (en) 2000-06-28
HUP9904143A3 HUP9904143A3 (en) 2002-11-28

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904143A HUP9904143A3 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phenylmethyl] -2h-1,3-diazepin-2-one,its preparation and its use as hiv protease inhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (en)
JP (1) JP2001503429A (en)
KR (1) KR20000053123A (en)
CN (1) CN1235601A (en)
AU (1) AU722489B2 (en)
BR (1) BR9712755A (en)
CA (1) CA2270963A1 (en)
CZ (1) CZ157499A3 (en)
EA (1) EA001154B1 (en)
EE (1) EE9900187A (en)
HU (1) HUP9904143A3 (en)
IL (1) IL129726A0 (en)
LV (1) LV12374B (en)
NO (1) NO992229L (en)
NZ (1) NZ335919A (en)
PL (1) PL333412A1 (en)
SI (1) SI9720071A (en)
SK (1) SK59599A3 (en)
WO (1) WO1998020009A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2282593A1 (en) * 1997-03-31 1998-10-08 Du Pont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
EP1089741A1 (en) * 1998-06-24 2001-04-11 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (en) 2000-06-13 2007-05-25 Centre Nat Rech Scient CYCLIC UREA COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
EP0607334B1 (en) * 1991-10-11 1997-07-30 The Du Pont Merck Pharmaceutical Company Cyclic ureas and analogues useful as retroviral protease inhibitiors

Also Published As

Publication number Publication date
EE9900187A (en) 1999-12-15
NO992229L (en) 1999-06-07
JP2001503429A (en) 2001-03-13
EA199900451A1 (en) 1999-12-29
IL129726A0 (en) 2000-02-29
CA2270963A1 (en) 1998-05-14
KR20000053123A (en) 2000-08-25
PL333412A1 (en) 1999-12-06
NO992229D0 (en) 1999-05-07
SI9720071A (en) 1999-12-31
EA001154B1 (en) 2000-10-30
LV12374B (en) 2000-04-20
HUP9904143A3 (en) 2002-11-28
BR9712755A (en) 1999-10-19
LV12374A (en) 1999-11-20
NZ335919A (en) 2000-09-29
AU722489B2 (en) 2000-08-03
CN1235601A (en) 1999-11-17
SK59599A3 (en) 1999-12-10
EP0937066A1 (en) 1999-08-25
CZ157499A3 (en) 1999-11-17
WO1998020009A1 (en) 1998-05-14
AU5103398A (en) 1998-05-29

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