LV12067B - USE OF 17BETA-N-SINGLE-CHOICE-CARBAMOYL-4-AZA-5-ALFA-ANDROST-1-EAN-3-ONU FOR MEDICINE MANUFACTURE - Google Patents

USE OF 17BETA-N-SINGLE-CHOICE-CARBAMOYL-4-AZA-5-ALFA-ANDROST-1-EAN-3-ONU FOR MEDICINE MANUFACTURE Download PDF

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Publication number
LV12067B
LV12067B LVP-98-34A LV980034A LV12067B LV 12067 B LV12067 B LV 12067B LV 980034 A LV980034 A LV 980034A LV 12067 B LV12067 B LV 12067B
Authority
LV
Latvia
Prior art keywords
aza
androst
methyl
hydrogen
compound
Prior art date
Application number
LVP-98-34A
Other languages
English (en)
Latvian (lv)
Other versions
LV12067A (lv
Inventor
Glenn J. Gormley
Elizabeth Stoner
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of LV12067A publication Critical patent/LV12067A/xx
Publication of LV12067B publication Critical patent/LV12067B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LVP-98-34A 1991-12-17 1998-03-03 USE OF 17BETA-N-SINGLE-CHOICE-CARBAMOYL-4-AZA-5-ALFA-ANDROST-1-EAN-3-ONU FOR MEDICINE MANUFACTURE LV12067B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80851091A 1991-12-17 1991-12-17

Publications (2)

Publication Number Publication Date
LV12067A LV12067A (lv) 1998-06-20
LV12067B true LV12067B (en) 1998-08-20

Family

ID=25198988

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-98-34A LV12067B (en) 1991-12-17 1998-03-03 USE OF 17BETA-N-SINGLE-CHOICE-CARBAMOYL-4-AZA-5-ALFA-ANDROST-1-EAN-3-ONU FOR MEDICINE MANUFACTURE

Country Status (6)

Country Link
US (2) US6268376B1 (fr)
EP (1) EP0547691B1 (fr)
JP (1) JP2538489B2 (fr)
CA (1) CA2084799C (fr)
DE (1) DE69218364T2 (fr)
LV (1) LV12067B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2084799C (fr) 1991-12-17 2003-01-28 Glenn J. Gormley Methode de prevention du carcinome prostatique a l'aide de 17 beta-n-monosubstitue-carbamyl-4-aza-5 alpha-androst-1 -en-3-ones
EP0547687A1 (fr) * 1991-12-18 1993-06-23 Merck & Co. Inc. 17-bêta-substitués adamantyle/norbornanyle-4-aza-5-alpha-androsta-1-en-3-ones et androsta-3-ones
WO1993023420A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVEAUX 4-AZA-5α-ANDROSTANE-3-ONES SUBSTITUES EN POSITION 7β EN TANT QU'INHIBITEURS DE LA 5α-REDUCTASE
CA2174234A1 (fr) * 1993-11-04 1995-05-11 Raman K. Bakshi Derives de 4-aza-steroide substitue en position 7 utilises comme inhibiteurs de 5-alpha-reductase
US6177404B1 (en) 1996-10-15 2001-01-23 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
US6093722A (en) 1997-02-26 2000-07-25 Sankyo Company, Limited Method for treating prostate cancer
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
KR100872722B1 (ko) * 2002-06-28 2008-12-05 주식회사 중외제약 피나스테라이드의 제조방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR830000085B1 (ko) * 1978-04-13 1983-02-08 제임스 에프. 너우톤 5α-환원효소 억제제로서 유용한 4-아자-17-치환-5α-안드로스탄-3-온류의 제조방법
AU527030B2 (en) 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
ZA851426B (en) * 1984-02-27 1986-10-29 Merck & Co Inc 17 beta-n-monosubstituted carbamoyl-4-aza-5 alpha-androst-1-en-3-ones as 5 alpha reductase inhibitors
US5049562A (en) 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
GB8505862D0 (en) 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3888378T2 (de) * 1987-04-03 1994-09-29 Merck & Co Inc Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
US5021575A (en) 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5300294A (en) 1990-06-27 1994-04-05 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
IE76452B1 (en) 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
CA2084799C (fr) 1991-12-17 2003-01-28 Glenn J. Gormley Methode de prevention du carcinome prostatique a l'aide de 17 beta-n-monosubstitue-carbamyl-4-aza-5 alpha-androst-1 -en-3-ones
EP0547687A1 (fr) 1991-12-18 1993-06-23 Merck & Co. Inc. 17-bêta-substitués adamantyle/norbornanyle-4-aza-5-alpha-androsta-1-en-3-ones et androsta-3-ones

Also Published As

Publication number Publication date
US6268376B1 (en) 2001-07-31
CA2084799A1 (fr) 1993-06-18
US20010049376A1 (en) 2001-12-06
JP2538489B2 (ja) 1996-09-25
LV12067A (lv) 1998-06-20
CA2084799C (fr) 2003-01-28
EP0547691B1 (fr) 1997-03-19
EP0547691A1 (fr) 1993-06-23
US6432971B2 (en) 2002-08-13
DE69218364T2 (de) 1997-09-25
DE69218364D1 (de) 1997-04-24
JPH05255381A (ja) 1993-10-05

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