LV10724B - Human follicle stimulating hormone receptor - Google Patents
Human follicle stimulating hormone receptor Download PDFInfo
- Publication number
- LV10724B LV10724B LVP-93-1136A LV931136A LV10724B LV 10724 B LV10724 B LV 10724B LV 931136 A LV931136 A LV 931136A LV 10724 B LV10724 B LV 10724B
- Authority
- LV
- Latvia
- Prior art keywords
- fsh
- receptor
- fragment
- leu
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (24)
- LV 10724 Izgudrojuma formula 1. Praktiski tīrs cilvēka folikulstimulējošā hormona (FSH) receptors. tā fragments vai mutants, kas spēj saistīt FSH.
- 2. FSH receptors pēc 1. punkta ar aminoskābju secību 1-678, kāda tā attēlota secībā ID No: 2.
- 3. FSH receptors pēc 2. punkta, kas atšķiras ar to, ka citoplazmas domēns ir aizvākts.
- 4. FSH receptors pēc 3. punkta, kas atšķiras ar to, ka transmembrānas domēns ir aizvākts.
- 5. FSH receptors pēc 1. punkta ar aminoskābju secību 1-349, kāda tā attēlota secībā ID No: 2 vai ievērojamu tās daju ar praktiski tādu pašu FSH saistīšanas spēju raksturojumu.
- 6. Izolēta DNS. kas kodē cilvēka FSH receptoru, tā fragmentu vai mutantu, kas spēj saistīt FSH.
- 7. Izolēta DNS pēc 6. punkta ar tādu nukleotīdu secību, kāda tā attēlota secībā ID No: 1.
- 8. Izolēta DNS pēc 7. punkta, kurā nukleotīdu secība, kas kodē FSH receptora citoplazmas domēnu, ir aizvākta.
- 9. Izolēta DNS pēc 8. punkta, kurā nukleotīdu secība, kas kodē FSH receptora transmembrānas domēnu, ir aizvākta. 1
- 10. Izolēta DNS pēc 6. punkta ar nukleotidu secību, kas kodē aminoskābju secību 1*349, kā tā attēlota secībā ID No: 2, vai ievērojamu tās daļu ar praktiski tādu pašu FSH saistīšanas spēju raksturojumu.
- 11. Rekombinantais ekspresijas vektors, kas ietver DNS pēc viena no 6.-10. punktiem.
- 12. Šūna, kas transfektēta ar ekspresijas vektoru pēc 11. punkta.
- 13. Šūna pēc 12. punkta, kas ir zīdītāja šūna.
- 14. Paņēmiens FSH saistītspējīga cilvēka FSH receptora, tā fragmenta vai mutanta iegūšanai, kas ietver šūnas pēc 12. punkta kultivēšanu barojošā vidē un receptora izdalīšanu no minētās šūnas.
- 15. Paņēmiens pēc 14. punkta, kas atšķiras ar to, ka šūna ir zīdītāja šūna.
- 16. Farmaceitiskā kompozīcija, kas ietver cilvēka FSH receptoru, tā fragmentu vai mutantu, kas spēj saistīties ar FSH, un farmaceitiski pieņemamu nesēju.
- 17. Kompozīcija pēc 16. punkta, kas ietver cilvēka FSH receptora fragmentu, pie kam minētais fragments ietver cilvēka FSH receptora aminogrupas gala ekstracelulāro domēnu vai ievērojamu tā daļu ar praktiski tādu pašu FSH saistīšanas spēju raksturojumu.
- 18. Uzlabots paņēmiens cilvēka FSH noteikšanai izmantojot FSH receptoru, kas atšķiras ar to, ka FSH receptors ir praktiski tīrs cilvēka FSH receptors vai tā fragments vai tā mutants, kas spēj saistīt FSH.
- 19. Paņēmiens pēc 18. punkta, kas atšķiras ar to, ka tajā izmanto cilvēka FSH receptora fragmentu, kas satur cilvēka FSH receptora aminogrupas gala ekstracelulāro domēnu vai ievērojamu tā daļu ar praktiski tādu pašu FSH saistīšanas spēju raksturojumu.
- 20. Praktiski tīra cilvēka FSH receptora, tā fragmenta vai mutanta pielietojums tādas farmaceitiskās kompozīcijas ražošanai, kas pacienta organismā pazemina endogēnā FSH aktivitāti.
- 21. Praktiski tīra cilvēka FSH receptora, tā fragmenta vai mutanta pielietojums tādas farmaceitiskās kompozīcijas ražošanai, kuras ievadīšana organismā novērš folikulu augšanu un nobriešanu sieviešu dzimuma pacientā.
- 22. Praktiski tīra cilvēka FSH receptora, tā fragmenta vai mutanta pielietojums tādas farmaceitiskās kompozīcijas ražošanai, kuras ievadīšana organismā novērš spermatoģenēzi vīriešu dzimuma pacientā. 2 LV 10724
- 23. Pielietojums pēc 20., 21. vai 22. punkta, kas atšķiras ar to, ka minētā kompozīcija ietver cilvēka FSH receptora fragmentu, kurš satur cilvēka FSH receptora aminogrupas gala ekstracelulāro domēnu vai ievērojamu tā daļu ar praktiski tādu pašu FSH saistīšanas spēju raksturojumu.
- 24. Paņēmiens parauga analizēšanai, lai tajā noteiktu vielas ar FSH bioloģisko aktivitāti, kas ietver: rekombinantas šūnu līnijas kultivēšanu minētā parauga klātienē, pie kam minētā šūnu līnija ir spējīga ekspresēt cilvēka FSH receptoru; nosakāmas bioloģiskās atbildes novērošanu FSH klātienē; jebkuras šādas bioloģiskās atbildes izmērīšanu. 3
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67008591A | 1991-03-15 | 1991-03-15 | |
PCT/US1992/000122 WO1992016620A1 (en) | 1991-03-15 | 1992-01-02 | Human follicle stimulating hormone receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
LV10724A LV10724A (lv) | 1995-06-20 |
LV10724B true LV10724B (en) | 1995-12-20 |
Family
ID=24688922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-93-1136A LV10724B (en) | 1991-03-15 | 1993-10-11 | Human follicle stimulating hormone receptor |
Country Status (19)
Country | Link |
---|---|
US (3) | US6121016A (lv) |
EP (2) | EP0575357B1 (lv) |
JP (1) | JP3581148B2 (lv) |
KR (1) | KR100245250B1 (lv) |
AT (2) | ATE224446T1 (lv) |
AU (1) | AU671417B2 (lv) |
CA (1) | CA2106061C (lv) |
DE (2) | DE69232779T2 (lv) |
DK (1) | DK0575357T3 (lv) |
ES (1) | ES2183806T3 (lv) |
FI (1) | FI109360B (lv) |
GE (1) | GEP19991604B (lv) |
LT (1) | LT3973B (lv) |
LV (1) | LV10724B (lv) |
MX (1) | MX9203350A (lv) |
NO (1) | NO315517B1 (lv) |
RU (1) | RU2193599C2 (lv) |
UA (1) | UA43826C2 (lv) |
WO (1) | WO1992016620A1 (lv) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3949893A (en) * | 1992-03-30 | 1993-11-08 | Akzo Nobel N.V. | Human gonadotropin receptor (FSH receptor) |
EP1557432B1 (en) | 1996-02-20 | 2013-08-21 | Merck Serono SA | Hybrid proteins which form heterodimers |
CA2250975A1 (en) * | 1996-04-15 | 1997-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble 7-transmembrane domain g-protein-coupled receptor compositions and methods |
US6521641B1 (en) * | 1998-10-08 | 2003-02-18 | Allergan, Inc. | Male anti-fertility agents |
US7273932B1 (en) | 1999-05-28 | 2007-09-25 | The University Of Cincinnati | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
EP1287135A2 (en) * | 2000-05-18 | 2003-03-05 | Bayer Aktiengesellschaft | Regulation of human follicle stimulating hormone-like g protein-coupled receptor |
US20030175889A1 (en) * | 2002-01-23 | 2003-09-18 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated versions of human G protein coupled receptor: FSHR |
EP1466620A1 (en) * | 2003-04-11 | 2004-10-13 | AXXAM S.r.l. | Compounds modulating FSHR and therapeutic uses thereof |
US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652450A (en) | 1984-08-31 | 1987-03-24 | Research Corporation | Bacterial FSH binding inhibitor |
US4761371A (en) | 1985-02-12 | 1988-08-02 | Genentech, Inc. | Insulin receptor |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US4921808A (en) * | 1986-06-25 | 1990-05-01 | The Albany Medical College Of Union University | Method for determining follicle stimulating hormone |
US4960700A (en) * | 1986-12-24 | 1990-10-02 | Genentech, Inc. | Compositions and methods for the synthesis and assay of a mammalian enkephalinase |
ES2068388T3 (es) * | 1989-05-05 | 1995-04-16 | Genentech Inc | Moleculas de receptor de hormona de la glucoproteina. |
US5155218A (en) * | 1990-05-08 | 1992-10-13 | Neurogenetic Corporation | Dna encoding human 5-ht1d receptors |
-
1992
- 1992-01-02 JP JP50530292A patent/JP3581148B2/ja not_active Expired - Lifetime
- 1992-01-02 AT AT92904833T patent/ATE224446T1/de not_active IP Right Cessation
- 1992-01-02 AT AT01202809T patent/ATE505486T1/de not_active IP Right Cessation
- 1992-01-02 ES ES92904833T patent/ES2183806T3/es not_active Expired - Lifetime
- 1992-01-02 DE DE69232779T patent/DE69232779T2/de not_active Expired - Lifetime
- 1992-01-02 DK DK92904833T patent/DK0575357T3/da active
- 1992-01-02 RU RU93057956/13A patent/RU2193599C2/ru active
- 1992-01-02 DE DE69233805T patent/DE69233805D1/de not_active Expired - Lifetime
- 1992-01-02 WO PCT/US1992/000122 patent/WO1992016620A1/en active IP Right Grant
- 1992-01-02 EP EP92904833A patent/EP0575357B1/en not_active Expired - Lifetime
- 1992-01-02 EP EP01202809A patent/EP1167385B1/en not_active Expired - Lifetime
- 1992-01-02 AU AU12514/92A patent/AU671417B2/en not_active Expired
- 1992-01-02 CA CA002106061A patent/CA2106061C/en not_active Expired - Lifetime
- 1992-01-02 GE GEAP19921579A patent/GEP19991604B/en unknown
- 1992-02-01 UA UA93004376A patent/UA43826C2/uk unknown
- 1992-06-25 MX MX9203350A patent/MX9203350A/es unknown
-
1993
- 1993-09-14 NO NO19933272A patent/NO315517B1/no not_active IP Right Cessation
- 1993-09-14 FI FI934023A patent/FI109360B/fi active
- 1993-09-15 KR KR1019930702771A patent/KR100245250B1/ko not_active IP Right Cessation
- 1993-10-11 LV LVP-93-1136A patent/LV10724B/en unknown
- 1993-12-20 LT LTIP1631A patent/LT3973B/lt not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/482,855 patent/US6121016A/en not_active Expired - Lifetime
- 1995-06-07 US US08/487,886 patent/US5744448A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,986 patent/US6372711B1/en not_active Expired - Lifetime
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