LU503112B1 - Use of invs protein in preparation of medicament for repairing heavy metal-induced testicular injury - Google Patents

Use of invs protein in preparation of medicament for repairing heavy metal-induced testicular injury Download PDF

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Publication number
LU503112B1
LU503112B1 LU503112A LU503112A LU503112B1 LU 503112 B1 LU503112 B1 LU 503112B1 LU 503112 A LU503112 A LU 503112A LU 503112 A LU503112 A LU 503112A LU 503112 B1 LU503112 B1 LU 503112B1
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Luxembourg
Prior art keywords
protein
invs
injury
insdqualifier
insdfeature
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LU503112A
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English (en)
Inventor
Linxi Li
Original Assignee
The Second Affiliated Hospital And Yuying Childrens Hospital Of Wenzhou Medical Univ
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Publication of LU503112B1 publication Critical patent/LU503112B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)

Claims (10)

BL-5586 LU503112 ANSPRÜCHE
1. Verwendung eines INVS-Proteins bei der Herstellung eines Arzneimittels zur Reparatur einer schwermetallinduzierten Hodenschadigung, wobei das INVS-Protein eine in SEQ ID NO. 1 dargestellte Aminosäuresequenz aufweist.
2. Verwendung nach Anspruch 1, wobei ein für das INVS-Protein kodierendes Gen eine in SEQ ID NO. 2 dargestellte Aminosäuresequenz aufweist.
3. Verwendung nach Anspruch 2, wobei ein Primerpaar zur Amplifikation des für das INVS-Protein kodierenden Gens in SEQ ID NO.3 und SEQ ID NO. 4 dargestellt ist.
4. Verwendung nach Anspruch 1, wobei die schwermetallinduzierte Hodenschädigung eine Schädigung des Samenepithels des Samenkanälchens im Hoden und/oder eine strukturelle Schadigung eines Zytoskelettproteins der Hoden umfasst.
5. Verwendung nach Anspruch 4, wobei die Schädigung des Samenepithels des Samenkanälchens im Hoden eine strukturelle Schädigung des Samenepithels des Samenkanälchens im Hoden umfasst.
6. Verwendung nach irgendeinem der Ansprüche 1 bis 5, wobei das Schwermetall Cadmium umfasst.
7. Arzneimittel zur Prävention und Behandlung einer Hodenschädigung, wobei das Arzneimittel einen rekombinanten Expressionsvektor, der ein fur ein INVS-Protein kodierendes Gen umfasst, umfasst.
BL-5586 LU503112
8. Arzneimittel nach Anspruch 7, wobei ein Basisvektor des rekombinanten Expressionsvektors pCl-neo umfasst.
9. Arzneimittel nach Anspruch 8, wobei das für das INVS-Protein kodierende Gen zwischen den Restriktionsstellen Xhol und Notl des Basisvektors angeordnet ist.
10. Arzneimittel nach Anspruch 9, wobei eine wirksame Dosis des Arzneimittels 5-50 ug des rekombinanten Expressionsvektors pro Hoden beträgt.
LU503112A 2021-12-07 2022-11-25 Use of invs protein in preparation of medicament for repairing heavy metal-induced testicular injury LU503112B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111486020.0A CN114129708B (zh) 2021-12-07 2021-12-07 Invs蛋白在制备修复重金属诱导的睾丸损伤的药物中的应用

Publications (1)

Publication Number Publication Date
LU503112B1 true LU503112B1 (en) 2023-06-07

Family

ID=80385026

Family Applications (1)

Application Number Title Priority Date Filing Date
LU503112A LU503112B1 (en) 2021-12-07 2022-11-25 Use of invs protein in preparation of medicament for repairing heavy metal-induced testicular injury

Country Status (3)

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CN (1) CN114129708B (de)
LU (1) LU503112B1 (de)
ZA (1) ZA202204058B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2033032B1 (en) * 2022-07-15 2024-01-25 The Second Affiliated Hospital And Yuying Childrens Hospital Of Wenzhou Medical Univ USE OF Dv13-DshC PEPTIDE FRAGMENT IN PREPARATION OF MEDICAMENT FOR REPAIRING TESTICULAR INJURY

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111569048B (zh) * 2020-05-22 2023-04-18 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 LamG5肽在制备修复睾丸中支持细胞损伤的药物中的应用
CN111494612B (zh) * 2020-05-22 2023-04-25 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 层粘蛋白α2功能区在制备维持或修复血睾屏障功能的药物中的应用
CN112516293A (zh) * 2020-12-02 2021-03-19 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 层粘蛋白α2功能区LamG3/4/5在制备预防避孕药诱导的睾丸损伤的药物中的应用

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CN114129708B (zh) 2024-06-07
CN114129708A (zh) 2022-03-04
ZA202204058B (en) 2022-06-29

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Effective date: 20230607