LT4339B - Melatonino panaudojimas gamyboje vaistų, skirtų gydyti ligonius, kenčiančius nuo palinkimo į vaistus - Google Patents
Melatonino panaudojimas gamyboje vaistų, skirtų gydyti ligonius, kenčiančius nuo palinkimo į vaistus Download PDFInfo
- Publication number
- LT4339B LT4339B LT97-135A LT97135A LT4339B LT 4339 B LT4339 B LT 4339B LT 97135 A LT97135 A LT 97135A LT 4339 B LT4339 B LT 4339B
- Authority
- LT
- Lithuania
- Prior art keywords
- melatonin
- benzodiazepine
- medicament
- treatment
- benzodiazepine drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/381,535 US6469044B1 (en) | 1995-02-01 | 1995-02-01 | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
Publications (2)
Publication Number | Publication Date |
---|---|
LT97135A LT97135A (en) | 1997-12-29 |
LT4339B true LT4339B (lt) | 1998-05-25 |
Family
ID=23505399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT97-135A LT4339B (lt) | 1995-02-01 | 1997-08-01 | Melatonino panaudojimas gamyboje vaistų, skirtų gydyti ligonius, kenčiančius nuo palinkimo į vaistus |
Country Status (13)
Country | Link |
---|---|
US (3) | US6469044B1 (de) |
EP (1) | EP0724878B1 (de) |
KR (1) | KR100425045B1 (de) |
AR (1) | AR003921A1 (de) |
DE (1) | DE69512760T2 (de) |
ES (1) | ES2139842T3 (de) |
HK (1) | HK1001218A1 (de) |
IL (1) | IL114296A (de) |
LT (1) | LT4339B (de) |
RO (1) | RO116771B1 (de) |
RU (1) | RU2182001C2 (de) |
UA (1) | UA63878C2 (de) |
ZA (1) | ZA96548B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6469044B1 (en) * | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
IL130171A (en) * | 1999-05-27 | 2004-06-01 | Neurim Pharma 1991 | Melatonin for use in preventing and treating tardive dyskinesia, pharmaceutical preparations containing it and its use in the manufacture of medicines |
IL144900A (en) * | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
US6998112B2 (en) * | 2003-03-18 | 2006-02-14 | Arthur Zuckerman | Sleep inducing toothpaste made with natural herbs and a natural hormone |
CA2556753C (en) * | 2004-02-20 | 2014-11-25 | Lifescape Biosciences Incorporated | Compositions and methods for sleep regulation |
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
CN103442727B (zh) | 2011-02-11 | 2016-08-10 | Zx制药有限责任公司 | 多微粒l-薄荷醇制剂及相关方法 |
RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
CA2909591C (en) | 2013-04-23 | 2017-03-28 | Zx Pharma, Llc | Enteric coated multiparticulate composition with proteinaceous subcoat |
WO2018078429A1 (en) | 2016-10-31 | 2018-05-03 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
US10849856B2 (en) | 2016-10-31 | 2020-12-01 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
WO2024079125A1 (en) | 2022-10-14 | 2024-04-18 | Société des Produits Nestlé S.A. | Sustained release melatonin compositions |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0513702A2 (de) | 1991-05-13 | 1992-11-19 | I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C. | Melatoninderivate zur Behandlung von Schlafstörungen und zur Pre-Anästhesie |
EP0518468A1 (de) | 1991-05-09 | 1992-12-16 | Neurim Pharmaceuticals (1991) Limited | Melatonin enthaltende Arzneimittel |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4600723A (en) | 1983-05-18 | 1986-07-15 | Monash University | Method for minimizing disturbances in circadian rhythms of bodily performance and function |
AU601736B2 (en) | 1986-05-23 | 1990-09-20 | Sanofi Sante Nutrition Animale Sa | Coated veterinary implants |
US4800087A (en) | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
US5242941A (en) | 1990-12-04 | 1993-09-07 | State Of Oregon | Methods of treating circadian rhythm disorders |
US5449683A (en) | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
US6469044B1 (en) * | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
-
1995
- 1995-02-01 US US08/381,535 patent/US6469044B1/en not_active Expired - Lifetime
- 1995-06-06 EP EP95303853A patent/EP0724878B1/de not_active Expired - Lifetime
- 1995-06-06 ES ES95303853T patent/ES2139842T3/es not_active Expired - Lifetime
- 1995-06-06 DE DE69512760T patent/DE69512760T2/de not_active Expired - Lifetime
- 1995-06-23 IL IL11429695A patent/IL114296A/xx not_active IP Right Cessation
-
1996
- 1996-01-24 ZA ZA96548A patent/ZA96548B/xx unknown
- 1996-01-29 UA UA97073940A patent/UA63878C2/uk unknown
- 1996-01-29 KR KR1019970705034A patent/KR100425045B1/ko not_active IP Right Cessation
- 1996-01-29 RO RO97-01338A patent/RO116771B1/ro unknown
- 1996-01-29 RU RU97113435/14A patent/RU2182001C2/ru active
- 1996-01-30 AR ARP960101224A patent/AR003921A1/es not_active Application Discontinuation
-
1997
- 1997-08-01 LT LT97-135A patent/LT4339B/lt not_active IP Right Cessation
-
1998
- 1998-01-06 HK HK98100103A patent/HK1001218A1/xx not_active IP Right Cessation
-
2002
- 2002-04-08 US US10/117,054 patent/US20020156121A1/en not_active Abandoned
- 2002-05-14 US US10/144,037 patent/US6833383B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0518468A1 (de) | 1991-05-09 | 1992-12-16 | Neurim Pharmaceuticals (1991) Limited | Melatonin enthaltende Arzneimittel |
EP0513702A2 (de) | 1991-05-13 | 1992-11-19 | I.F.L.O. ISTITUTO FARMACOLOGICO LOMBARDO S.A.S. di Giorgio & Aldo Laguzzi & C. | Melatoninderivate zur Behandlung von Schlafstörungen und zur Pre-Anästhesie |
Non-Patent Citations (8)
Title |
---|
ACUNA CASTROVIEJO D ET AL.: "Diurnal variations of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy", J PINEAL RES, 1986, pages 101 - 102 |
CARDINALI DP ET AL.: "Functional links between benzodiazepine and GABA receptors and pineal activity", ADV BIOCHEM PSYCHOPHARMACOL., 1986, pages 155 - 164, XP000571409 |
D. GREENBLAT, R. SHADER: "Greenblatt DJ, Shader RI. Dependence, tolerance, and addiction to benzodiazepines: clinical and pharmacokinetic considerations", DRUG METABOLISM REVIEWS, 1978, pages 13 - 28 |
GUARDIOLA-LEMAîTRE, B. ET AL.: "Combined effects of diazepam and melatonin in two tests for anxiolytic activity in the mouse", PHARMACOL. BIOCHEM. BEHAV., 1992, pages 405 - 408, XP023807215, DOI: doi:10.1016/0091-3057(92)90118-Y |
I. M. MCINTYRE: "Suppression of plasma melatonin by a single dose of the benzodiazepine alprazolan in humans", BIOL. PSYCHIAT., 1988, pages 105 - 108 |
KABUTO M, NAMURA I, SAITOH Y.: "Nocturnal enhancement of plasma melatonin could be suppressed by benzodiazepines in humans", ENDOCRINOLOGIA JAPONICA, 1986, pages 405 - 414 |
NILES L.P., PICKERING D.S., ARCISZEWSKI M.A: "Effects of chronic melatonin administration on gaba and diazepam binding in rat brain", J. NEURAL TRANSM., 1987, pages 117 - 124, XP000571404, DOI: doi:10.1007/BF01252513 |
Y. ANIS, I. NIR, U. SCHMIDT, N. ZISAPEL: "Modification by oxazepam of the diurnal variations in brain125I-melatonin binding sites in sham-operated and pinealectomized rats", JOURNAL OF NEURAL TRANSMISSION, 1992, pages 155 - 166, XP000571405, DOI: doi:10.1007/BF01250668 |
Also Published As
Publication number | Publication date |
---|---|
US20020156121A1 (en) | 2002-10-24 |
IL114296A0 (en) | 1995-10-31 |
EP0724878A3 (de) | 1996-08-21 |
IL114296A (en) | 1999-10-28 |
US6469044B1 (en) | 2002-10-22 |
ZA96548B (en) | 1996-08-14 |
ES2139842T3 (es) | 2000-02-16 |
US6833383B2 (en) | 2004-12-21 |
KR19980701640A (ko) | 1998-06-25 |
DE69512760D1 (de) | 1999-11-18 |
LT97135A (en) | 1997-12-29 |
US20030040539A1 (en) | 2003-02-27 |
HK1001218A1 (en) | 1998-06-05 |
RO116771B1 (ro) | 2001-06-29 |
EP0724878A2 (de) | 1996-08-07 |
UA63878C2 (en) | 2004-02-16 |
RU2182001C2 (ru) | 2002-05-10 |
EP0724878B1 (de) | 1999-10-13 |
DE69512760T2 (de) | 2000-05-31 |
AR003921A1 (es) | 1998-09-30 |
KR100425045B1 (ko) | 2004-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 20070129 |