LT4291B - Junginiai, veikiantys prieš progesteroną ir estrogeną, skirti bendrai moterų kontracepcijai - Google Patents

Junginiai, veikiantys prieš progesteroną ir estrogeną, skirti bendrai moterų kontracepcijai Download PDF

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Publication number
LT4291B
LT4291B LT97-107A LT97107A LT4291B LT 4291 B LT4291 B LT 4291B LT 97107 A LT97107 A LT 97107A LT 4291 B LT4291 B LT 4291B
Authority
LT
Lithuania
Prior art keywords
hydroxy
phenyl
estra
progesterone
compound
Prior art date
Application number
LT97-107A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT97107A (en
Inventor
Kristof Chwalisz
Klaus Stoeckemann
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of LT97107A publication Critical patent/LT97107A/xx
Publication of LT4291B publication Critical patent/LT4291B/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
LT97-107A 1994-12-23 1997-06-20 Junginiai, veikiantys prieš progesteroną ir estrogeną, skirti bendrai moterų kontracepcijai LT4291B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4447402 1994-12-23

Publications (2)

Publication Number Publication Date
LT97107A LT97107A (en) 1997-10-27
LT4291B true LT4291B (lt) 1998-02-25

Family

ID=6537602

Family Applications (1)

Application Number Title Priority Date Filing Date
LT97-107A LT4291B (lt) 1994-12-23 1997-06-20 Junginiai, veikiantys prieš progesteroną ir estrogeną, skirti bendrai moterų kontracepcijai

Country Status (24)

Country Link
US (1) US6362237B1 (xx)
EP (1) EP0799042A1 (xx)
JP (1) JPH10511378A (xx)
KR (1) KR100385663B1 (xx)
CN (1) CN1075375C (xx)
AU (1) AU710819B2 (xx)
BG (1) BG62384B1 (xx)
BR (1) BR9510550A (xx)
CA (1) CA2208321A1 (xx)
CZ (1) CZ288062B6 (xx)
EE (1) EE03421B1 (xx)
FI (1) FI972623A0 (xx)
HU (1) HUT77519A (xx)
IL (1) IL116505A0 (xx)
LT (1) LT4291B (xx)
LV (1) LV11883B (xx)
NO (1) NO314066B1 (xx)
NZ (1) NZ298769A (xx)
PL (1) PL183843B1 (xx)
RO (1) RO121086B1 (xx)
SI (1) SI9520136A (xx)
SK (1) SK284538B6 (xx)
WO (1) WO1996019997A1 (xx)
ZA (1) ZA9510926B (xx)

Families Citing this family (28)

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DE19652408C2 (de) * 1996-12-06 2002-04-18 Schering Ag Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln
DE19745085A1 (de) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
US6326392B1 (en) 1997-11-06 2001-12-04 American Home Products Corporation Anti-estrogen plus progestin containing oral contraceptives
DE19809845A1 (de) 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
JP4382735B2 (ja) 2005-10-06 2009-12-16 独立行政法人科学技術振興機構 神経因性疼痛治療剤
EA201070715A1 (ru) * 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции

Citations (18)

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EP0005715A1 (de) 1978-06-06 1979-12-12 Heidelberger Druckmaschinen Aktiengesellschaft Umführtrommel für umstellbare Schön- und Widerdruckmaschinen mit zwei Bogentragflächen
US4386085A (en) 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
DE3322285A1 (de) 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0129499A2 (de) 1983-06-15 1984-12-27 Schering Aktiengesellschaft 13alpha-Alkylgonane, deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0139608A2 (de) 1983-10-12 1985-05-02 Schering Aktiengesellschaft Prostaglandine und Antigestagene zur Geburtseinleitung oder für den Schwangerschaftsabbruch
EP0190759A2 (de) 1985-02-07 1986-08-13 Schering Aktiengesellschaft 11 Beta-Phenyl-Gonane, deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0219447A2 (de) 1985-09-13 1987-04-22 Schering Aktiengesellschaft Antigestagene zur Verschiebung der endometrialen Reifung
US4670426A (en) 1983-03-24 1987-06-02 Yeda Research And Development Co., Ltd. Interruption of fertility in mammals by post-coital pills
EP0277676A1 (en) 1987-01-23 1988-08-10 Akzo N.V. New ll-aryl steroid derivatives
EP0283428A1 (de) 1987-03-18 1988-09-21 Schering Aktiengesellschaft 19,11beta-Überbrückte Steroide, deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0289073A1 (en) 1987-04-24 1988-11-02 Akzo N.V. Novel 11-aryloestrane and 11-arylpregnane derivatives
EP0310541A1 (de) 1987-10-01 1989-04-05 Schering Aktiengesellschaft Antigestagen- und antiöstrogenwirksame Verbindungen zur Geburtseinleitung und zum Schwangerschaftsabbruch sowie zur Behandlung gynäkologischer Störungen
EP0321010A1 (en) 1987-12-12 1989-06-21 Akzo N.V. New 11-arylsteroid compounds
EP0404283A2 (de) 1989-06-23 1990-12-27 Schering Aktiengesellschaft 11-Beta-aryl-4-estrene, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
EP0411735A1 (de) 1989-08-04 1991-02-06 Schering Aktiengesellschaft Cycloakylenazole, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese enthalten sowie ihre Verwendung zur Herstellung von Arzneimitteln
DE4213005A1 (de) 1991-04-24 1992-10-29 Ciba Geigy Ag Antikonzeption bei weiblichen primaten ohne beeinflussung des menstruellen zyklus
WO1993021145A1 (en) 1992-04-21 1993-10-28 Ligand Pharmaceuticals Inc. Non-steroid progesterone receptor agonist and antagonist compounds and methods
WO1993023020A1 (en) 1992-05-12 1993-11-25 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310542B1 (de) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagen- und antiöstrogenwirksame Verbindungen zur Behandlung hormonabhängiger Tumoren
GB8813353D0 (en) * 1988-06-06 1988-07-13 Ici Plc Therapeutic product

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005715A1 (de) 1978-06-06 1979-12-12 Heidelberger Druckmaschinen Aktiengesellschaft Umführtrommel für umstellbare Schön- und Widerdruckmaschinen mit zwei Bogentragflächen
US4386085A (en) 1981-01-09 1983-05-31 Roussell Uclaf Novel steroids
US4670426A (en) 1983-03-24 1987-06-02 Yeda Research And Development Co., Ltd. Interruption of fertility in mammals by post-coital pills
EP0129499A2 (de) 1983-06-15 1984-12-27 Schering Aktiengesellschaft 13alpha-Alkylgonane, deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3322285A1 (de) 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0139608A2 (de) 1983-10-12 1985-05-02 Schering Aktiengesellschaft Prostaglandine und Antigestagene zur Geburtseinleitung oder für den Schwangerschaftsabbruch
EP0190759A2 (de) 1985-02-07 1986-08-13 Schering Aktiengesellschaft 11 Beta-Phenyl-Gonane, deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0219447A2 (de) 1985-09-13 1987-04-22 Schering Aktiengesellschaft Antigestagene zur Verschiebung der endometrialen Reifung
EP0277676A1 (en) 1987-01-23 1988-08-10 Akzo N.V. New ll-aryl steroid derivatives
EP0283428A1 (de) 1987-03-18 1988-09-21 Schering Aktiengesellschaft 19,11beta-Überbrückte Steroide, deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0289073A1 (en) 1987-04-24 1988-11-02 Akzo N.V. Novel 11-aryloestrane and 11-arylpregnane derivatives
EP0310541A1 (de) 1987-10-01 1989-04-05 Schering Aktiengesellschaft Antigestagen- und antiöstrogenwirksame Verbindungen zur Geburtseinleitung und zum Schwangerschaftsabbruch sowie zur Behandlung gynäkologischer Störungen
EP0321010A1 (en) 1987-12-12 1989-06-21 Akzo N.V. New 11-arylsteroid compounds
EP0404283A2 (de) 1989-06-23 1990-12-27 Schering Aktiengesellschaft 11-Beta-aryl-4-estrene, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
EP0411735A1 (de) 1989-08-04 1991-02-06 Schering Aktiengesellschaft Cycloakylenazole, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese enthalten sowie ihre Verwendung zur Herstellung von Arzneimitteln
DE4213005A1 (de) 1991-04-24 1992-10-29 Ciba Geigy Ag Antikonzeption bei weiblichen primaten ohne beeinflussung des menstruellen zyklus
WO1993021145A1 (en) 1992-04-21 1993-10-28 Ligand Pharmaceuticals Inc. Non-steroid progesterone receptor agonist and antagonist compounds and methods
WO1993023020A1 (en) 1992-05-12 1993-11-25 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein

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BATISTA MC ET AL.: "Daily administration of the progesterone antagonist RU 486 prevents implantation in the cycling guinea pig", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, pages 82 - 86
CILLINS ET AL.: "Blockade of spontaneous midcycle gonadotropin surge in monkeys by RU 486: a progesterone antagonist or agonist", J CLIN METAB, 1986, pages 1270 - 1276
DANFORTH DR ET AL.: "Contraceptive potential of RU 486 by ovulation inhibition: III. Preliminary observations on once weekly oral administration", CONTRACEPTION, 1989, pages 195 - 200, XP026183142, DOI: doi:10.1016/0010-7824(89)90006-1
GLASIER A.THONG K.J.DEWAR M.MACKIE M.BAIRD D.: "Original Article Mifepristone (RU 486) Compared with High-Dose Estrogen and Progestogen for Emergency Postcoital Contraception", N ENGL J MED, 1992, pages 1041 - 1044
KAWANO ET AL.: "Effect of RU 486 on Glycogen Metabolism in Endometrium", ACTA OBSTETRICA ET GYNECOLOGICA JAPONICA, 1989, pages 1507 - 1511
KEKKONEN ET AL.: "Interference with ovulation gy sequential treatment with the antiprogesterone RU 486 and synthetic progestin", FERTIL STERIL., 1990, pages 4747
L. MARTIN ET AL.: "FURTHER STUDIES ON THE EFFECTS OF OESTROGENS AND ANTI-OESTROGENS ON EARLY PREGNANCY IN MICE", J REPROD FERTIL, 1963, pages 239 - 247
M.L. SWAHN ET AL.: "The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium", HUMAN REPRODUCTION, 1990, pages 402 - 408, XP008002480
MARTIN R. SCHNEIDER: "Acetoxy substituted 1,1,2-triphenylbut-1-enes: Estrogenic, antiestrogenic and mammary tumor inhibiting activity", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1986, pages 119 - 124
PURI CP ET AL.: "Gonadal and pituitary responses to progesterone antagonist ZK 98.299 during the follicular phase of the menstrual cycle in bonnet monkeys", CONTRACEPTION, 1989, pages 227 - 243
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SCHIEWECK K, BHATNAGAR AS, MATTER A.: "CGS 16949A, a new nonsteroidal aromatase inhibitor: effects on hormone-dependent and -independent tumors in vivo", CANCER RES., 1988, pages 834 - 838
SINGH M. M., KAMBOJ V. P.: "Fetal resorption in rats treated with an antiestrogen in relation to luteal phase nidatory estrogen secretion", ACTA ENDOCRINOL (COPENH)., 1992, pages 444 - 450

Also Published As

Publication number Publication date
BG62384B1 (bg) 1999-10-29
EE9700143A (et) 1997-12-15
WO1996019997A1 (de) 1996-07-04
LT97107A (en) 1997-10-27
KR980700866A (ko) 1998-04-30
KR100385663B1 (ko) 2003-08-19
SI9520136A (en) 1997-12-31
HUT77519A (hu) 1998-05-28
CA2208321A1 (en) 1996-07-04
CN1171051A (zh) 1998-01-21
NO314066B1 (no) 2003-01-27
MX9704742A (es) 1997-10-31
US6362237B1 (en) 2002-03-26
EE03421B1 (et) 2001-06-15
CZ195397A3 (en) 1997-11-12
BG101553A (en) 1998-09-30
BR9510550A (pt) 1998-06-16
NO972877D0 (no) 1997-06-20
NZ298769A (en) 2000-09-29
RO121086B1 (ro) 2006-12-29
NO972877L (no) 1997-08-22
EP0799042A1 (de) 1997-10-08
FI972623A (fi) 1997-06-18
PL183843B1 (pl) 2002-07-31
CN1075375C (zh) 2001-11-28
ZA9510926B (en) 1996-07-03
CZ288062B6 (cs) 2001-04-11
LV11883A (lv) 1997-12-20
PL320786A1 (en) 1997-10-27
JPH10511378A (ja) 1998-11-04
AU4433796A (en) 1996-07-19
IL116505A0 (en) 1996-03-31
AU710819B2 (en) 1999-09-30
SK78997A3 (en) 1998-01-14
LV11883B (lv) 1998-05-20
FI972623A0 (fi) 1997-06-18
SK284538B6 (sk) 2005-06-02

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