LT3558321T - Chinolinų dariniai kaip dyrk1a ir (arba) dyrk1b kinazių inhibitoriai - Google Patents
Chinolinų dariniai kaip dyrk1a ir (arba) dyrk1b kinazių inhibitoriaiInfo
- Publication number
- LT3558321T LT3558321T LTEPPCT/US2017/067527T LT17067527T LT3558321T LT 3558321 T LT3558321 T LT 3558321T LT 17067527 T LT17067527 T LT 17067527T LT 3558321 T LT3558321 T LT 3558321T
- Authority
- LT
- Lithuania
- Prior art keywords
- dyrk1b
- dyrk1a
- quinolines
- kinases
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16460096 | 2016-12-23 | ||
| PCT/US2017/067527 WO2018119039A1 (en) | 2016-12-23 | 2017-12-20 | Derivatives of quinolines as inhibitors of dyrk1a and/or dyrk1b kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3558321T true LT3558321T (lt) | 2023-05-10 |
Family
ID=57777491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2017/067527T LT3558321T (lt) | 2016-12-23 | 2017-12-20 | Chinolinų dariniai kaip dyrk1a ir (arba) dyrk1b kinazių inhibitoriai |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10577365B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4183786A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7134973B2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT3558321T (cg-RX-API-DMAC7.html) |
| PL (1) | PL3558321T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018119039A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10577365B2 (en) * | 2016-12-23 | 2020-03-03 | Felicitex Therapeutics, Inc. | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases |
| CN110483508B (zh) * | 2019-08-29 | 2020-05-08 | 山东大学 | 化合物、制备方法及在制备GSK-3β抑制剂中的应用 |
| WO2021076886A1 (en) | 2019-10-18 | 2021-04-22 | The Regents Of The University Of California | 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders |
| KR20230003981A (ko) * | 2021-06-30 | 2023-01-06 | 한국화학연구원 | DYRK1 억제제인 피롤로[3,2-c]피리딘 유도체 및 이의 용도 |
| EP4415817A1 (en) * | 2021-10-12 | 2024-08-21 | BioSplice Therapeutics, Inc. | 1h-pyrrolo[2,3-b]pyridines as dyrk1a inhibitors |
| WO2025069008A1 (en) | 2023-09-28 | 2025-04-03 | Graviton Bioscience Bv | Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors |
| CN120904163A (zh) * | 2025-10-09 | 2025-11-07 | 北京大学第一医院(北京大学第一临床医学院) | 一种喹啉类化合物或其药学上可接受的盐及其制备方法和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100368411C (zh) | 2002-03-28 | 2008-02-13 | 卫材R&D管理有限公司 | 作为c-Jun N-末端激酶抑制剂用于治疗神经变性疾病的7-氮杂吲哚类化合物 |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| US7507826B2 (en) * | 2004-03-30 | 2009-03-24 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| US20090233955A1 (en) * | 2004-12-08 | 2009-09-17 | Frazee James S | 1H-Pyrrolo[2,3-B]Pyridnes |
| ES2431466T3 (es) * | 2006-06-30 | 2013-11-26 | Sunesis Pharmaceuticals, Inc. | Inhibidores de piridinonil pdk1 |
| US8552019B2 (en) * | 2008-12-05 | 2013-10-08 | Merck Sharp & Dohme Corp. | Inhibitors of phosphoinositide dependent kinase 1 (PDK1) |
| JP6086326B2 (ja) * | 2010-05-24 | 2017-03-01 | ユニヴァーシティー オブ ロチェスター | 二環式ヘテロアリールキナーゼ阻害剤および使用方法 |
| MX342879B (es) * | 2010-07-30 | 2016-10-14 | Oncotherapy Science Inc * | Derivados de quinolina e inhibidores de cinasa de cremallera de leucina embrionica materna que los contienen. |
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| WO2012129338A1 (en) | 2011-03-22 | 2012-09-27 | Amgen Inc. | Azole compounds as pim inhibitors |
| EP2729465A2 (en) | 2011-07-05 | 2014-05-14 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for producing azaindoles |
| AU2012298510B2 (en) * | 2011-08-19 | 2016-10-27 | Diaxonhit | DYRK1 inhibitors and uses thereof |
| US10485800B2 (en) | 2012-11-30 | 2019-11-26 | The University Of Rochester | Mixed lineage kinase inhibitors for HIV/AIDS therapies |
| WO2016000615A1 (en) | 2014-07-02 | 2016-01-07 | Sunshine Lake Pharma Co., Ltd. | Heteroaryl compounds and pharmaceutical applications thereof |
| US10577365B2 (en) * | 2016-12-23 | 2020-03-03 | Felicitex Therapeutics, Inc. | Derivatives of quinoline as inhibitors of DYRK1A and/or DYRK1B kinases |
-
2017
- 2017-12-20 US US15/848,786 patent/US10577365B2/en active Active
- 2017-12-20 PL PL17883520.3T patent/PL3558321T3/pl unknown
- 2017-12-20 LT LTEPPCT/US2017/067527T patent/LT3558321T/lt unknown
- 2017-12-20 WO PCT/US2017/067527 patent/WO2018119039A1/en not_active Ceased
- 2017-12-20 JP JP2019534721A patent/JP7134973B2/ja active Active
- 2017-12-20 EP EP22214338.0A patent/EP4183786A1/en not_active Withdrawn
- 2017-12-20 EP EP17883520.3A patent/EP3558321B1/en active Active
-
2022
- 2022-08-24 JP JP2022133200A patent/JP2022166286A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3558321B1 (en) | 2023-02-01 |
| JP7134973B2 (ja) | 2022-09-12 |
| US20180179199A1 (en) | 2018-06-28 |
| PL3558321T3 (pl) | 2023-10-23 |
| EP3558321A1 (en) | 2019-10-30 |
| EP3558321A4 (en) | 2020-05-27 |
| WO2018119039A1 (en) | 2018-06-28 |
| EP4183786A1 (en) | 2023-05-24 |
| JP2022166286A (ja) | 2022-11-01 |
| US10577365B2 (en) | 2020-03-03 |
| JP2020502252A (ja) | 2020-01-23 |
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