LT3536333T - Depo sistema, apimanti glatiramero acetatą - Google Patents

Depo sistema, apimanti glatiramero acetatą

Info

Publication number
LT3536333T
LT3536333T LTEP18205308.2T LT18205308T LT3536333T LT 3536333 T LT3536333 T LT 3536333T LT 18205308 T LT18205308 T LT 18205308T LT 3536333 T LT3536333 T LT 3536333T
Authority
LT
Lithuania
Prior art keywords
glatiramer acetate
depot system
depot
glatiramer
acetate
Prior art date
Application number
LTEP18205308.2T
Other languages
English (en)
Inventor
Ehud Marom
Shai Rubnov
Original Assignee
Mapi Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mapi Pharma Limited filed Critical Mapi Pharma Limited
Publication of LT3536333T publication Critical patent/LT3536333T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Epoxy Resins (AREA)
LTEP18205308.2T 2010-01-04 2010-08-19 Depo sistema, apimanti glatiramero acetatą LT3536333T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29192810P 2010-01-04 2010-01-04

Publications (1)

Publication Number Publication Date
LT3536333T true LT3536333T (lt) 2022-11-10

Family

ID=44226217

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP10840699.2T LT2398488T (lt) 2010-01-04 2010-08-19 Depo sistema, apimanti glatiramero acetatą
LTEP18205308.2T LT3536333T (lt) 2010-01-04 2010-08-19 Depo sistema, apimanti glatiramero acetatą

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP10840699.2T LT2398488T (lt) 2010-01-04 2010-08-19 Depo sistema, apimanti glatiramero acetatą

Country Status (20)

Country Link
US (1) US8796226B2 (lt)
EP (2) EP3536333B1 (lt)
JP (2) JP5916622B2 (lt)
CN (3) CN107184954A (lt)
AU (1) AU2010337822B2 (lt)
BR (1) BR112012016459B1 (lt)
CA (1) CA2784394C (lt)
CY (1) CY1120975T1 (lt)
DK (2) DK2398488T3 (lt)
ES (2) ES2699692T3 (lt)
HK (2) HK1245667A1 (lt)
HR (2) HRP20221208T1 (lt)
HU (2) HUE040390T2 (lt)
LT (2) LT2398488T (lt)
MX (2) MX2020003805A (lt)
PL (2) PL2398488T3 (lt)
PT (2) PT3536333T (lt)
SI (1) SI2398488T1 (lt)
TR (1) TR201818858T4 (lt)
WO (1) WO2011080733A1 (lt)

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US8377885B2 (en) 2010-01-04 2013-02-19 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
ES2601892T3 (es) 2011-04-21 2017-02-16 Mapi Pharma Limited Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes
US20140357752A1 (en) 2011-09-18 2014-12-04 Bio Plasmar Ltd. Bio-degradable compositions and use thereof
WO2014128079A1 (en) * 2013-02-19 2014-08-28 Synthon B.V. Glatiramer acetate multidose formulation
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US10493122B2 (en) 2014-03-17 2019-12-03 Mapi Pharma Ltd. Sublingual delivery of glatiramer acetate
ES2960753T3 (es) 2015-09-21 2024-03-06 Teva Pharmaceuticals Int Gmbh Formulaciones de olanzapina de liberación sostenida
US20210220428A1 (en) * 2016-06-30 2021-07-22 Stem Cell Medicine Ltd. Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells
EP3503907B1 (en) * 2016-08-28 2024-03-13 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) * 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
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WO2018172850A1 (en) 2017-03-20 2018-09-27 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulaitons
US11167003B2 (en) 2017-03-26 2021-11-09 Mapi Pharma Ltd. Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems
WO2018211486A1 (en) * 2017-05-15 2018-11-22 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells
US11510946B2 (en) 2017-05-15 2022-11-29 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with adipose-derived stem cells
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US20230256058A1 (en) * 2020-06-29 2023-08-17 Mapi Pharma Ltd. Low burst-release liraglutide depot systems
WO2022094473A1 (en) * 2020-11-02 2022-05-05 Simcha IL-18, Inc. Interleukin-18 variants and methods of use
US20240100012A1 (en) 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form
JP2024507598A (ja) * 2021-01-29 2024-02-21 ティオンラボ・セラピューティクス 初期放出制御されたデポー組成物及びその製造方法
US11865213B2 (en) 2021-07-05 2024-01-09 Mapi Pharma Ltd. Semaglutide depot systems and use thereof
CA3227324A1 (en) 2021-07-06 2023-01-12 Mark Hasleton Treatment of serotonin reuptake inhibitor withdrawal syndrome
WO2023170493A1 (en) * 2022-03-07 2023-09-14 Hadidi Naghmeh Drug delivery using a parenteral pharmaceutical composition
WO2024054879A1 (en) * 2022-09-06 2024-03-14 Regents Of The University Of Michigan Biodegradable polymeric particles for delivery of positively charged therapeutic agents

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Also Published As

Publication number Publication date
MX349162B (es) 2017-07-14
CN107184954A (zh) 2017-09-22
JP5916622B2 (ja) 2016-05-11
PL3536333T3 (pl) 2022-12-05
BR112012016459A2 (pt) 2017-10-03
US8796226B2 (en) 2014-08-05
HK1245667A1 (zh) 2018-08-31
HUE060304T2 (hu) 2023-02-28
CN107661490A (zh) 2018-02-06
US20120015891A1 (en) 2012-01-19
PL2398488T3 (pl) 2019-03-29
AU2010337822B2 (en) 2016-03-17
CA2784394A1 (en) 2011-07-07
AU2010337822A1 (en) 2012-07-12
HK1244430A1 (zh) 2018-08-10
EP2398488A4 (en) 2014-06-11
SI2398488T1 (sl) 2019-02-28
PT2398488T (pt) 2018-12-20
CA2784394C (en) 2016-12-13
WO2011080733A1 (en) 2011-07-07
HRP20182076T1 (hr) 2019-02-08
ES2699692T3 (es) 2019-02-12
DK3536333T3 (da) 2022-10-24
HRP20221208T1 (hr) 2022-12-09
EP3536333A1 (en) 2019-09-11
BR112012016459B1 (pt) 2020-01-14
JP2013516403A (ja) 2013-05-13
CY1120975T1 (el) 2019-12-11
JP2016074696A (ja) 2016-05-12
EP2398488A1 (en) 2011-12-28
EP2398488B1 (en) 2018-11-14
CN107661490B (zh) 2021-12-31
CN102686235A (zh) 2012-09-19
LT2398488T (lt) 2019-01-25
MX2012007760A (es) 2012-08-01
EP3536333B1 (en) 2022-08-03
MX2020003805A (es) 2022-05-05
HUE040390T2 (hu) 2019-03-28
DK2398488T3 (en) 2019-01-28
PT3536333T (pt) 2022-11-11
TR201818858T4 (tr) 2019-01-21
ES2928900T3 (es) 2022-11-23

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