LT2994153T - Peptidų ir peptidų aktyvių ingredientų konjugatas, skirtas vaisto nukreipimui į inkstus - Google Patents
Peptidų ir peptidų aktyvių ingredientų konjugatas, skirtas vaisto nukreipimui į inkstusInfo
- Publication number
- LT2994153T LT2994153T LTEP14720485.3T LT14720485T LT2994153T LT 2994153 T LT2994153 T LT 2994153T LT 14720485 T LT14720485 T LT 14720485T LT 2994153 T LT2994153 T LT 2994153T
- Authority
- LT
- Lithuania
- Prior art keywords
- conjugate
- targeting
- peptides
- peptide
- active ingredient
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13002432 | 2013-05-07 | ||
| PCT/EP2014/001026 WO2014180534A1 (de) | 2013-05-07 | 2014-04-16 | Peptide und peptid-wirkstoff-konjugate für renales targeting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2994153T true LT2994153T (lt) | 2018-11-26 |
Family
ID=48325358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP14720485.3T LT2994153T (lt) | 2013-05-07 | 2014-04-16 | Peptidų ir peptidų aktyvių ingredientų konjugatas, skirtas vaisto nukreipimui į inkstus |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10065993B2 (lt) |
| EP (1) | EP2994153B1 (lt) |
| JP (1) | JP6510494B2 (lt) |
| CN (1) | CN105188728B (lt) |
| CA (1) | CA2911542C (lt) |
| DK (1) | DK2994153T3 (lt) |
| ES (1) | ES2697348T3 (lt) |
| HR (1) | HRP20181882T1 (lt) |
| HU (1) | HUE040491T2 (lt) |
| LT (1) | LT2994153T (lt) |
| SI (1) | SI2994153T1 (lt) |
| WO (1) | WO2014180534A1 (lt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2994152T1 (sl) * | 2013-05-07 | 2018-12-31 | Merck Patent Gmbh | Konjugati za zaščito nefrotoksičnih učinkovin |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| CN105169404B (zh) * | 2015-09-02 | 2018-06-26 | 上海市普陀区中心医院 | 一种用于治疗去势抵抗性前列腺癌的靶向前药及其纳米制剂和制备方法 |
| US11090358B2 (en) | 2015-09-09 | 2021-08-17 | Fred Hutchinson Cancer Research Center | Cartilage-homing peptides |
| EP3386530A4 (en) * | 2015-12-11 | 2019-08-28 | Fred Hutchinson Cancer Research Center | PEPTIDES FOR RENAL THERAPY |
| AU2018210157B2 (en) | 2017-01-18 | 2022-10-06 | Fred Hutchinson Cancer Center | Peptide compositions and methods of use thereof for disrupting TEAD interactions |
| JP7280193B2 (ja) | 2017-03-16 | 2023-05-23 | ブレイズ バイオサイエンス， インコーポレイテッド | 軟骨ホーミングペプチドコンジュゲート及びその使用方法 |
| EP3638290A4 (en) * | 2017-06-15 | 2021-04-07 | Blaze Bioscience, Inc. | KIDNEY HOMING PEPTIDE CONJUGATES AND METHOD OF USING THEREOF |
| US11866466B2 (en) | 2017-12-19 | 2024-01-09 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| CN111867615A (zh) * | 2018-02-21 | 2020-10-30 | 小利兰.斯坦福大学托管委员会 | 具有次级作用方式的新型抗微生物剂组合物及方法 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| WO2024118760A1 (en) * | 2022-11-29 | 2024-06-06 | Cornell University | Peptide-linked drug delivery system |
| CN116832171B (zh) * | 2023-06-05 | 2024-03-05 | 中国人民解放军总医院第八医学中心 | 靶向损伤肾脏组织的外泌体载药系统、构建方法及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4645661A (en) | 1984-06-29 | 1987-02-24 | St. Jude Children's Research Hospital | Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same |
| AU724326B2 (en) * | 1996-09-09 | 2000-09-14 | Zealand Pharmaceuticals A/S | Peptide prodrugs containing an alpha-hydroxyacid linker |
| WO1999046283A1 (en) | 1998-03-09 | 1999-09-16 | Zealand Pharmaceuticals A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| AU2001265343B2 (en) * | 2000-05-31 | 2006-08-03 | Pestka Biomedical Laboratories, Inc. | Phosphorylated polypeptides and uses related thereto |
| US20030135888A1 (en) * | 2001-09-26 | 2003-07-17 | Tong Zhu | Genes that are modulated by posttranscriptional gene silencing |
| CA2620228C (en) * | 2005-08-26 | 2014-12-09 | Action Pharma A/S | Therapeutically active .alpha.-msh analogues |
| DE102007004424A1 (de) * | 2007-01-23 | 2008-07-24 | Bayer Schering Pharma Aktiengesellschaft | Eisenoxid-bindende Peptide |
| EP2277547A1 (de) | 2009-07-20 | 2011-01-26 | Merck Patent GmbH | Epsilon-Polylysin-Konjugate und deren Verwendung |
-
2014
- 2014-04-16 CN CN201480025638.9A patent/CN105188728B/zh active Active
- 2014-04-16 US US14/890,059 patent/US10065993B2/en active Active
- 2014-04-16 EP EP14720485.3A patent/EP2994153B1/de active Active
- 2014-04-16 CA CA2911542A patent/CA2911542C/en active Active
- 2014-04-16 DK DK14720485.3T patent/DK2994153T3/en active
- 2014-04-16 ES ES14720485T patent/ES2697348T3/es active Active
- 2014-04-16 HU HUE14720485A patent/HUE040491T2/hu unknown
- 2014-04-16 SI SI201430960T patent/SI2994153T1/sl unknown
- 2014-04-16 JP JP2016512240A patent/JP6510494B2/ja active Active
- 2014-04-16 LT LTEP14720485.3T patent/LT2994153T/lt unknown
- 2014-04-16 WO PCT/EP2014/001026 patent/WO2014180534A1/de active Application Filing
-
2018
- 2018-11-12 HR HRP20181882TT patent/HRP20181882T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2911542C (en) | 2022-06-07 |
| CN105188728B (zh) | 2021-11-09 |
| SI2994153T1 (sl) | 2018-12-31 |
| US10065993B2 (en) | 2018-09-04 |
| CA2911542A1 (en) | 2014-11-13 |
| WO2014180534A1 (de) | 2014-11-13 |
| CN105188728A (zh) | 2015-12-23 |
| ES2697348T3 (es) | 2019-01-23 |
| HRP20181882T1 (hr) | 2019-01-11 |
| HUE040491T2 (hu) | 2019-03-28 |
| JP2016519134A (ja) | 2016-06-30 |
| DK2994153T3 (en) | 2018-11-26 |
| JP6510494B2 (ja) | 2019-05-08 |
| EP2994153A1 (de) | 2016-03-16 |
| US20160199505A1 (en) | 2016-07-14 |
| EP2994153B1 (de) | 2018-08-15 |
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