LT2531200T - Kristalizacijos būdas ir bioprieinamumas - Google Patents

Kristalizacijos būdas ir bioprieinamumas

Info

Publication number
LT2531200T
LT2531200T LTEP11740284.2T LT11740284T LT2531200T LT 2531200 T LT2531200 T LT 2531200T LT 11740284 T LT11740284 T LT 11740284T LT 2531200 T LT2531200 T LT 2531200T
Authority
LT
Lithuania
Prior art keywords
bioavailability
crystallization method
crystallization
Prior art date
Application number
LTEP11740284.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
Mazen Hanna
Ning SHAN
Miranda L. Cheney
David R. Weyna
Raymond Houck
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2010/043916 external-priority patent/WO2011014781A1/en
Priority claimed from PCT/US2010/043892 external-priority patent/WO2011014766A2/en
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of LT2531200T publication Critical patent/LT2531200T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTEP11740284.2T 2010-02-06 2011-02-02 Kristalizacijos būdas ir bioprieinamumas LT2531200T (lt)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US30211010P 2010-02-06 2010-02-06
US31287910P 2010-03-11 2010-03-11
US31850310P 2010-03-29 2010-03-29
US33302810P 2010-05-10 2010-05-10
US33304110P 2010-05-10 2010-05-10
US35954410P 2010-06-29 2010-06-29
PCT/US2010/043916 WO2011014781A1 (en) 2009-07-31 2010-07-30 Novel oral forms of a phosphonic acid derivative
PCT/US2010/043892 WO2011014766A2 (en) 2009-07-31 2010-07-30 Crystallization method and bioavailability
US12/847,568 US8399023B2 (en) 2009-07-31 2010-07-30 Crystallization method and bioavailability
US37981410P 2010-09-03 2010-09-03
US45577810P 2010-10-26 2010-10-26
PCT/US2011/023427 WO2011097269A1 (en) 2010-02-06 2011-02-02 Crystallization method and bioavailability

Publications (1)

Publication Number Publication Date
LT2531200T true LT2531200T (lt) 2017-09-25

Family

ID=44355747

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11740284.2T LT2531200T (lt) 2010-02-06 2011-02-02 Kristalizacijos būdas ir bioprieinamumas

Country Status (15)

Country Link
EP (1) EP2531200B1 (cg-RX-API-DMAC7.html)
JP (2) JP5792748B2 (cg-RX-API-DMAC7.html)
AU (2) AU2012216632B2 (cg-RX-API-DMAC7.html)
CA (1) CA2826548A1 (cg-RX-API-DMAC7.html)
CY (1) CY1119192T1 (cg-RX-API-DMAC7.html)
DK (1) DK2531200T3 (cg-RX-API-DMAC7.html)
ES (1) ES2638072T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20171201T1 (cg-RX-API-DMAC7.html)
HU (1) HUE035744T2 (cg-RX-API-DMAC7.html)
IL (1) IL221306A0 (cg-RX-API-DMAC7.html)
LT (1) LT2531200T (cg-RX-API-DMAC7.html)
PL (1) PL2531200T3 (cg-RX-API-DMAC7.html)
PT (1) PT2531200T (cg-RX-API-DMAC7.html)
SI (1) SI2531200T1 (cg-RX-API-DMAC7.html)
WO (1) WO2011097269A1 (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US8980868B2 (en) 2009-07-31 2015-03-17 Thar Pharmaceuticals, Inc. Oral forms of a phosphonic acid derivative
PT2459176T (pt) 2009-07-31 2017-12-11 Gruenenthal Gmbh Método de cristalização e biodisponibilidade
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
WO2011097269A1 (en) * 2010-02-06 2011-08-11 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
CN102268023B (zh) * 2011-08-15 2013-04-17 南京丰融化学技术有限公司 头孢类衍生物cxd的晶型
US9999629B2 (en) 2012-05-14 2018-06-19 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10413560B2 (en) 2012-05-14 2019-09-17 Antecip Bioventures Ii Llc Dosage forms for oral administration of zoledronic acid or related compounds for treating disease
US11654152B2 (en) 2012-05-14 2023-05-23 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating disease
US10413561B2 (en) 2012-05-14 2019-09-17 Antecip Bioventures Ii Llc Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases
US9956238B2 (en) 2014-05-15 2018-05-01 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
US20140349974A1 (en) * 2014-08-12 2014-11-27 Antecip Bioventures Ii Llc Zoledronic acid dosage forms for the treatment of pain
US10493085B2 (en) 2012-05-14 2019-12-03 Antecip Bioventures Ii Llc Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases
US10350227B2 (en) 2012-05-14 2019-07-16 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US10463682B2 (en) 2012-05-14 2019-11-05 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating low back pain
US10016445B2 (en) 2012-05-14 2018-07-10 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
CN104349781A (zh) * 2012-05-14 2015-02-11 安泰赛普生物风投二代有限责任公司 用于减轻炎性疼痛或相关病症的包含唑来膦酸或相关化合物的组合物
EP2968371A4 (en) * 2013-03-12 2017-04-12 The Board of Trustees of the Leland Stanford Junior University Modulation of cellular dna repair activity to intercept malignancy
ES3042216T3 (en) * 2013-03-15 2025-11-19 Xortx Therapeutics Inc Xanthine oxidase inhibitor formulations
MX2016005396A (es) * 2013-10-25 2017-03-01 Antecip Bioventures Ii Llc Composiciones para administracion oral de acido zoledronico o compuestos relacionados para tratar enfermedades.
AU2016324482A1 (en) * 2015-09-18 2018-03-29 Thar Pharma, Llc Crystallization method and bioavailability
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis
KR102723076B1 (ko) * 2016-12-15 2024-11-28 제이투에이치바이오텍 (주) 3성분 코크리스탈
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR20220009954A (ko) 2019-04-17 2022-01-25 컴퍼스 패쓰파인더 리미티드 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677320B2 (en) * 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
CA2454200A1 (en) 2001-07-17 2003-01-30 Teva Pharmaceutical Industries Ltd. Dosage forms for immediate gastric release of a calcium transport stimulator coupled with delayed gastric release of a bis-phosphonate
US20040220264A1 (en) * 2003-03-17 2004-11-04 Yu Ruey J Bioavailability and improved delivery of acidic pharmaceutical drugs
DE602004019881D1 (de) * 2003-07-03 2009-04-23 Teva Pharma Kristallformen der zoledronsäure und deren natrioumsalze, amorphes natriumzoledronat und verfahren zu deren herstellung
US20060068010A1 (en) 2004-09-30 2006-03-30 Stephen Turner Method for improving the bioavailability of orally delivered therapeutics
JO3006B1 (ar) * 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
WO2011097269A1 (en) * 2010-02-06 2011-08-11 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
PT2459176T (pt) * 2009-07-31 2017-12-11 Gruenenthal Gmbh Método de cristalização e biodisponibilidade
US8980868B2 (en) * 2009-07-31 2015-03-17 Thar Pharmaceuticals, Inc. Oral forms of a phosphonic acid derivative
US9340565B2 (en) * 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
CN102070668B (zh) * 2010-12-23 2013-07-24 蚌埠丰原医药科技发展有限公司 一种利用相转移催化剂制备唑来膦酸及其钠盐的方法

Also Published As

Publication number Publication date
JP2016006096A (ja) 2016-01-14
EP2531200B1 (en) 2017-07-12
WO2011097269A1 (en) 2011-08-11
JP6190429B2 (ja) 2017-08-30
DK2531200T3 (en) 2017-09-11
JP2013519632A (ja) 2013-05-30
EP2531200A4 (en) 2014-01-08
JP5792748B2 (ja) 2015-10-14
CA2826548A1 (en) 2011-08-11
ES2638072T3 (es) 2017-10-18
EP2531200A1 (en) 2012-12-12
IL221306A0 (en) 2012-10-31
AU2012216632B2 (en) 2016-05-26
SI2531200T1 (sl) 2017-12-29
CY1119192T1 (el) 2018-02-14
HRP20171201T1 (hr) 2017-10-06
HUE035744T2 (en) 2018-05-28
AU2016219653B2 (en) 2018-05-31
WO2011097269A9 (en) 2012-12-27
PL2531200T3 (pl) 2017-10-31
AU2016219653A1 (en) 2016-09-15
PT2531200T (pt) 2017-08-24

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