KR970707116A - 테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제(tetrahydroisoquinoline derivative and medicinal preparation containing the same) - Google Patents

테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제(tetrahydroisoquinoline derivative and medicinal preparation containing the same) Download PDF

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Publication number
KR970707116A
KR970707116A KR1019970702878A KR19970702878A KR970707116A KR 970707116 A KR970707116 A KR 970707116A KR 1019970702878 A KR1019970702878 A KR 1019970702878A KR 19970702878 A KR19970702878 A KR 19970702878A KR 970707116 A KR970707116 A KR 970707116A
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KR
South Korea
Prior art keywords
alkyl
aryl
alkoxycarbonyl
alkoxy
alkylcarbonyloxy
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KR1019970702878A
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English (en)
Inventor
히로마사 고하마
노부유끼 나까따
마사히로 스즈끼
요우꼬 데라지마
Original Assignee
와찌 다까시
데루모 가부시끼가이샤
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Publication of KR970707116A publication Critical patent/KR970707116A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 피브리노겐 응집 억제 작용을 갖고, 항혈전제 또는 혈소판응집 저해제로서 유용하게 사용되는 하기 화학식(1)로 나타내는 테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제에 관한 것이다.
상기 화학식(1)에서, B 및 G는 알킬 등으로 치환될 수 있는 알킬렌을 나타내며; D는 수소, 알킬 등을 나타내며; E는 R1내지 R4에 의해 치환될 수 있는 2위치에서 G와 결합하는 1,2,3,4-테트라히드로퀴놀린을 나타내며; R1내지 R4는 각각 알킬 등을 나타내며; L은 히드록시 등을 나타내며; A는 화학식(2)의 치환기를 나타내며; 그리고 C는 탄소를 나타낸다.
상기 식에서 M 및 R5내지 R8은 수소, 알킬 등을 나타낸다.

Description

테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제(TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 화학식(1)의 표시된 테트라히드로이소퀴놀린 유도체 :
    상기 화학식(1)에서, B 및 G는 독립적으로 치환기로 치환될 수 있는 (C : 0-10)알킬렌을 나타내며(상기 치환기는 (C : 0-10)알킬, 아릴(C : 0-8)알킬, (C : 0-10)알킬아미노, 아실아미노, (C : 0-10)알콕시, 아릴(C : 0-8)알콕시, (아릴((C : 0-8)알킬)아미노, 히드록시 또는 할로게노를 나타냄) ; D는 수소, (C : 0-10)알킬, (C : 0-10)알콕시카르보닐 또는 아릴(C : 0-8)알콕시카르보닐, (C : 0-10)아릴카르보닐옥시(C : 0-10)알콕시카르보닐 또는 아릴(C : 0-10)알킬카르보닐옥시(C : 0-10)알콕시카르보닐을 나타내며; E는 치환기 R1, R2, R3및 R4로 치환될 수 있고 2위치에서 G와 결합하는 1,2,3,4-테트라히드로이소퀴놀린을 나타내며 (상기 치환기 R1, R2, R3, 및 R4는 독립적으로 (C : 0-10)알킬, 아릴(C : 0-8)알콕시, (아릴(C : 0-8)알킬)아미노, 히드록시 또는 할로게노를 나타냄); L은 히드록시, (C : 0-10)알킬아미노, 디(C : 0-10)알킬아미노, (아릴(C : 0-10)알킬)아미노, (C : 0-10)알콕시, 아릴(C : 0-8)알콕시, (C : 0-10)알킬카르보닐옥시(C : 0-10)알콕시, 또는 아릴(C : 0-10)알킬카르보닐옥시(C : 0-10)알콕시를 나타내며; 그리고, A는 하기 화학식(2)로 표시된 치환기를 나타내며 C는 탄소를 나타낸다.
    상기 화학식(2)에서, M은 수소, (C : 0-10)알킬, (C : 0-10)알콕시카르보닐 또는 아릴(C : 0-8)알콕시카르보닐, (C : 0-10)알킬카르보닐옥시(C : 0-10)알콕시카르보닐, 또는 아릴(C : 0-10)알킬카르보닐옥시(C : 0-10)알콕시카르보닐을 나타내며; 그리고, R5, R6, R7, 및 R8은 독립적으로 수소, (C : 0-10)알킬, 아릴(C : 0-8)알킬, (C : 0-10)알킬아미노, 아실아미노, (C : 0-10)알콕시, 아릴(C : 0-8)알콕시, , 히드록시 또는 할로게노를 나타내며; C는 탄소를 나타낸다.
  2. 제1항의 테트라히드로이소퀴놀린 유도체를 함유하는 의학제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970702878A 1994-11-01 1995-10-26 테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제(tetrahydroisoquinoline derivative and medicinal preparation containing the same) KR970707116A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP94/269146 1994-11-01
JP26914694 1994-11-01
JP95/109194 1995-05-08
JP10919495 1995-05-08
PCT/JP1995/002201 WO1996013497A1 (fr) 1994-11-01 1995-10-26 Derive de tetrahydroisoquinoleine et preparation medicinale contenant ce derive

Publications (1)

Publication Number Publication Date
KR970707116A true KR970707116A (ko) 1997-12-01

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KR1019970702878A KR970707116A (ko) 1994-11-01 1995-10-26 테트라히드로이소퀴놀린 유도체 및 그를 함유하는 의약 제제(tetrahydroisoquinoline derivative and medicinal preparation containing the same)

Country Status (7)

Country Link
US (1) US5789595A (ko)
EP (1) EP0790247A4 (ko)
KR (1) KR970707116A (ko)
CN (1) CN1167485A (ko)
AU (1) AU691677B2 (ko)
CA (1) CA2204006A1 (ko)
WO (1) WO1996013497A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
KR20110140139A (ko) * 2003-08-29 2011-12-30 오노 야꾸힝 고교 가부시키가이샤 Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도
CA2591399C (en) 2004-12-13 2014-05-20 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them

Also Published As

Publication number Publication date
EP0790247A1 (en) 1997-08-20
EP0790247A4 (en) 2000-07-19
US5789595A (en) 1998-08-04
WO1996013497A1 (fr) 1996-05-09
AU691677B2 (en) 1998-05-21
AU3753895A (en) 1996-05-23
CA2204006A1 (en) 1996-05-09
CN1167485A (zh) 1997-12-10

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