KR970700672A - 비페닐메탄 유도체의 칼륨염 및 이를 함유하는 약제(potassium salts of biphenylmethane derivatives and pharmaceuticals containing the same) - Google Patents

비페닐메탄 유도체의 칼륨염 및 이를 함유하는 약제(potassium salts of biphenylmethane derivatives and pharmaceuticals containing the same)

Info

Publication number
KR970700672A
KR970700672A KR1019960704121A KR19960704121A KR970700672A KR 970700672 A KR970700672 A KR 970700672A KR 1019960704121 A KR1019960704121 A KR 1019960704121A KR 19960704121 A KR19960704121 A KR 19960704121A KR 970700672 A KR970700672 A KR 970700672A
Authority
KR
South Korea
Prior art keywords
derivatives
potassium salts
salt
compound
biphenylylethane
Prior art date
Application number
KR1019960704121A
Other languages
English (en)
Inventor
테루카게 히라타
노부야 사카에
코이치 다무라
마사야수 오쿠히라
히로타가 아마노
마사하루 요코모토
준 노미야마
Original Assignee
구사이 요시히로
와쿠나가 세이야쿠 가부시키 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 구사이 요시히로, 와쿠나가 세이야쿠 가부시키 가이샤 filed Critical 구사이 요시히로
Publication of KR970700672A publication Critical patent/KR970700672A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 1칼륨 또는 2칼륨 2-〔〔5-에틸-3-〔2′-(1H-테트라졸-5-일)비페닐-4-일〕메틸-1,3,4-티아디아졸린-2-일리덴〕아미노카르보닐〕-1-시클로펜텐카르복실레이트, 상기 화합물을 함유하는 의약 조성물, 약제로서의 화합물의 사용 및 상기 화합물 투여에 의한 순환기계 질환의 치료법에 관한 것이다. 상기 화합물 1칼륨 또는 2칼륨은 경구 투여하는 경우, 강력한 안지오텐신Ⅱ 길항작용 및 혈압강하 효과를 가지며, 또한 높은 생체 이용률을 가져서 약제로서 유용하다.

Description

비페닐메탄 유도체의 칼륨염 및 이를 함유하는 약제(POTASSIUM SALTS OF BIPHENYLMETHANE DERIVATIVES AND PHARMACEUTICALS CONTANING THE SAME)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

1칼륨 또는 2칼륨 2-〔〔5-에틸-3-〔2′-(1H-테트라졸-5-일)비페닐-4-일〕메틸-1,3,4-티아디아졸린-2-일리덴〕아미노카르보닐〕-1-시클로펜텐카르복실레이트.
1칼륨 또는 2칼륨 2-〔〔5-에틸-3-〔2′-(1H-테트라졸-5-일)비페닐-4-일〕메틸-1,3,4-티아디아졸린-2-일리덴〕아미노카르보닐〕-1-시클로펜텐카르복실레이트 및 제약학적 담체를 함유하는 의약 조성물.
제2항에 있어서, 순환기 질환 치료용인 조성물.
제2항에 있어서, 고혈압 치료용인 조성물.
1칼륨 또는 2칼륨 2-〔〔5-에틸-3-〔2′-(1H-테트라졸-5-일)비페닐-4-일〕메틸-1,3,4-티아디아졸린-2-일리덴〕아미노카르보닐〕-1-시클로펜텐카르복실레이트를 유효성분으로서 함유하는 순환기계 질환 치료제.
제5항에 있어서, 상기 제제가 고혈압 치료용인 치료제.
KR1019960704121A 1994-02-10 1995-02-08 비페닐메탄 유도체의 칼륨염 및 이를 함유하는 약제(potassium salts of biphenylmethane derivatives and pharmaceuticals containing the same) KR970700672A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP1622094 1994-02-10
JP016220/1994 1994-02-10
JP128739/1994 1994-06-10
JP12873994 1994-06-10
PCT/JP1995/000174 WO1995021837A1 (fr) 1994-02-10 1995-02-08 Sel de potassium de derive biphenylmethane et medicament le contenant

Publications (1)

Publication Number Publication Date
KR970700672A true KR970700672A (ko) 1997-02-12

Family

ID=26352497

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960704121A KR970700672A (ko) 1994-02-10 1995-02-08 비페닐메탄 유도체의 칼륨염 및 이를 함유하는 약제(potassium salts of biphenylmethane derivatives and pharmaceuticals containing the same)

Country Status (10)

Country Link
EP (1) EP0744402B1 (ko)
KR (1) KR970700672A (ko)
CN (1) CN1140450A (ko)
AT (1) ATE169014T1 (ko)
CA (1) CA2181260A1 (ko)
DE (1) DE69503760T2 (ko)
DK (1) DK0744402T3 (ko)
ES (1) ES2120180T3 (ko)
GR (1) GR3027777T3 (ko)
WO (1) WO1995021837A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
US5912353A (en) * 1995-06-27 1999-06-15 Wakunaga Seiyaku Kabushiki Kaisha Process for producing tetrazolylated biphenylmethane derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326776A (en) * 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
KR950702544A (ko) * 1992-08-11 1995-07-29 구사이 요시히로 비페닐메탄 유도체 및 이를 함유하는 약제
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same

Also Published As

Publication number Publication date
AU1591295A (en) 1995-08-29
DK0744402T3 (da) 1999-05-03
DE69503760D1 (de) 1998-09-03
GR3027777T3 (en) 1998-11-30
ATE169014T1 (de) 1998-08-15
CA2181260A1 (en) 1995-08-17
DE69503760T2 (de) 1998-12-17
EP0744402B1 (en) 1998-07-29
EP0744402A4 (en) 1997-03-26
ES2120180T3 (es) 1998-10-16
EP0744402A1 (en) 1996-11-27
WO1995021837A1 (fr) 1995-08-17
CN1140450A (zh) 1997-01-15
AU685586B2 (en) 1998-01-22

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