KR970027089A - 신규 세팔로스포린 유도체 및 그 중간체 - Google Patents

신규 세팔로스포린 유도체 및 그 중간체 Download PDF

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Publication number
KR970027089A
KR970027089A KR1019950044287A KR19950044287A KR970027089A KR 970027089 A KR970027089 A KR 970027089A KR 1019950044287 A KR1019950044287 A KR 1019950044287A KR 19950044287 A KR19950044287 A KR 19950044287A KR 970027089 A KR970027089 A KR 970027089A
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KR
South Korea
Prior art keywords
group
formula
intermediates
compounds
pharmaceutically acceptable
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Application number
KR1019950044287A
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English (en)
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KR100449775B1 (ko
Inventor
윤석균
김계원
이상득
김원배
시게오 시미즈
신이찌로 시미즈
히로유끼 다까노
Original Assignee
유충식
동아제약 주식회사
시게오 시미즈
유겐가이샤 닛뽄이야쿠힝가이하츠겐큐쇼
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Application filed by 유충식, 동아제약 주식회사, 시게오 시미즈, 유겐가이샤 닛뽄이야쿠힝가이하츠겐큐쇼 filed Critical 유충식
Priority to KR1019950044287A priority Critical patent/KR100449775B1/ko
Publication of KR970027089A publication Critical patent/KR970027089A/ko
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Publication of KR100449775B1 publication Critical patent/KR100449775B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 구족식(Ia)로 표시되는 세펨화합물 및, 그의 약학적으로 허용 가능한 염 또는 에스테르, 그리고 또한 본 발명은 그 제조중간체로서 유용한 아래 구조식(II) 및 구조식(III)의 화합물을 제공한다.
식중 R은 수소원자 또는 보호기이고, R1은 카르복시기 또는 보호된 카르복시기이고 R2는 저급 플로로알킬, Z는 CH 또는 N이고 Het 아래 구조식의 기이다
본 발명의 화합물들은 그람양성균 및 그람음성균에 광범위한 항균활성을 가지며, 그 독성이 거의 없어서 새로운 향균제로서의 사용이 기대된다.

Description

신규 세팔로스포린 유도체 및 그 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 구조식(Ia)로 표시되는 세펨화합물 및, 그의 약학적으로 허용 가능한 염 또는 에스테르.
    식중 R은 수소원자 또는 보호기이고, R1은 카르복시기 또는 보호된 카르복시기이고 R2는 저급 플로로알킬, Z는 CH 또는 N이고 Het는 아래 구조식의 기이다.
  2. 하기 일반식(III)의 화합물 및, 그의 약학적으로 허용가능한 염 또는 에스테르.
    R1은 카르복시기 또는 보호된 카르복시기이고 Het는 아래 구조식의 기이다.
  3. 다음 구조식 (II)의 화합물.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019950044287A 1995-11-28 1995-11-28 신규세팔로스포린유도체및그중간체 KR100449775B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950044287A KR100449775B1 (ko) 1995-11-28 1995-11-28 신규세팔로스포린유도체및그중간체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950044287A KR100449775B1 (ko) 1995-11-28 1995-11-28 신규세팔로스포린유도체및그중간체

Publications (2)

Publication Number Publication Date
KR970027089A true KR970027089A (ko) 1997-06-24
KR100449775B1 KR100449775B1 (ko) 2005-08-17

Family

ID=37304052

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950044287A KR100449775B1 (ko) 1995-11-28 1995-11-28 신규세팔로스포린유도체및그중간체

Country Status (1)

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS56108794A (en) * 1980-11-27 1981-08-28 Fujisawa Pharmaceut Co Ltd Preparation of 7-amino-3-thiadiazolylthiomethyl-3-cephem- 4-carboxylic acid derivative
GR75487B (ko) * 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
JPH07173169A (ja) * 1993-08-02 1995-07-11 Takeda Chem Ind Ltd セフェム化合物、その製造法および抗菌組成物
JPH0761987A (ja) * 1993-08-24 1995-03-07 Takeda Chem Ind Ltd セフェム化合物、その製造法および抗菌組成物

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KR100449775B1 (ko) 2005-08-17

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