KR960700760A - 개선된 조영제(Improvements in or Relating to Contrast Agents) - Google Patents
개선된 조영제(Improvements in or Relating to Contrast Agents) Download PDFInfo
- Publication number
- KR960700760A KR960700760A KR1019950703924A KR19950703924A KR960700760A KR 960700760 A KR960700760 A KR 960700760A KR 1019950703924 A KR1019950703924 A KR 1019950703924A KR 19950703924 A KR19950703924 A KR 19950703924A KR 960700760 A KR960700760 A KR 960700760A
- Authority
- KR
- South Korea
- Prior art keywords
- contrast agent
- contrast
- chemically
- substance
- contrast agents
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title claims abstract 20
- 239000000203 mixture Substances 0.000 claims abstract 5
- 238000009472 formulation Methods 0.000 claims abstract 4
- 239000011236 particulate material Substances 0.000 claims abstract 4
- 238000002059 diagnostic imaging Methods 0.000 claims abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims abstract 2
- 238000012285 ultrasound imaging Methods 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims 6
- 239000007789 gas Substances 0.000 claims 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 4
- 239000002502 liposome Substances 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 239000007900 aqueous suspension Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- -1 methylene diester Chemical class 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000010298 pulverizing process Methods 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 239000013011 aqueous formulation Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- BLRXYTIIKIPJQL-UHFFFAOYSA-N dicarbide(1-) Chemical compound [C-]#C BLRXYTIIKIPJQL-UHFFFAOYSA-N 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 239000008350 hydrogenated phosphatidyl choline Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000001247 metal acetylides Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 125000000962 organic group Chemical group 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 150000008106 phosphatidylserines Chemical class 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000013618 particulate matter Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305351A GB9305351D0 (en) | 1993-03-16 | 1993-03-16 | Improvements in or relating to contrast agents |
| GB9305351.0 | 1993-03-16 | ||
| PCT/GB1994/000522 WO1994021302A1 (en) | 1993-03-16 | 1994-03-16 | Improvements in or relating to contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR960700760A true KR960700760A (ko) | 1996-02-24 |
Family
ID=10732118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950703924A KR960700760A (ko) | 1993-03-16 | 1994-03-16 | 개선된 조영제(Improvements in or Relating to Contrast Agents) |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0689462A1 (ja) |
| JP (1) | JPH08507781A (ja) |
| KR (1) | KR960700760A (ja) |
| CN (1) | CN1121314A (ja) |
| AU (1) | AU695529B2 (ja) |
| BR (1) | BR9406199A (ja) |
| CA (1) | CA2158359A1 (ja) |
| CZ (1) | CZ237195A3 (ja) |
| FI (1) | FI954326A (ja) |
| GB (1) | GB9305351D0 (ja) |
| HU (1) | HUT72984A (ja) |
| NO (1) | NO953638L (ja) |
| PL (1) | PL310657A1 (ja) |
| SK (1) | SK113795A3 (ja) |
| WO (1) | WO1994021302A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| US5333613A (en) * | 1993-03-23 | 1994-08-02 | Delineate | Microparticles as ultrasonic contrast media |
| US5897851A (en) * | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
| GB9511488D0 (en) * | 1995-06-07 | 1995-08-02 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| GB9622711D0 (en) | 1996-10-31 | 1997-01-08 | British Tech Group | Instrument having enhanced ultrasound visibility |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| US20070110674A1 (en) * | 2005-07-29 | 2007-05-17 | Yuhong Xu | Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems |
| NZ733010A (en) | 2014-12-31 | 2023-01-27 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods |
| IL262647B2 (en) | 2016-05-04 | 2023-03-01 | Lantheus Medical Imaging Inc | Methods and devices for preparing sharpness factors for ultrasound |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| GB201821049D0 (en) * | 2018-12-21 | 2019-02-06 | Ge Healthcare As | Ultrasound contrast agent and methods for use therof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| JPH0678247B2 (ja) * | 1988-10-04 | 1994-10-05 | 大塚製薬株式会社 | Ｎｍｒ造影用鉄含有製剤 |
| US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
| EP0627942B1 (en) * | 1992-03-06 | 1999-09-15 | Nycomed Imaging As | Improvements in or relating to contrast agents |
-
1993
- 1993-03-16 GB GB939305351A patent/GB9305351D0/en active Pending
-
1994
- 1994-03-16 CZ CZ952371A patent/CZ237195A3/cs unknown
- 1994-03-16 EP EP94909227A patent/EP0689462A1/en not_active Withdrawn
- 1994-03-16 HU HU9502693A patent/HUT72984A/hu unknown
- 1994-03-16 AU AU62153/94A patent/AU695529B2/en not_active Ceased
- 1994-03-16 CN CN94191800A patent/CN1121314A/zh active Pending
- 1994-03-16 KR KR1019950703924A patent/KR960700760A/ko not_active Application Discontinuation
- 1994-03-16 PL PL94310657A patent/PL310657A1/xx unknown
- 1994-03-16 SK SK1137-95A patent/SK113795A3/sk unknown
- 1994-03-16 CA CA002158359A patent/CA2158359A1/en not_active Abandoned
- 1994-03-16 WO PCT/GB1994/000522 patent/WO1994021302A1/en not_active Application Discontinuation
- 1994-03-16 BR BR9406199A patent/BR9406199A/pt not_active Application Discontinuation
- 1994-03-16 JP JP6520776A patent/JPH08507781A/ja active Pending
-
1995
- 1995-09-14 FI FI954326A patent/FI954326A/fi unknown
- 1995-09-15 NO NO953638A patent/NO953638L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9406199A (pt) | 1995-12-12 |
| HU9502693D0 (en) | 1995-11-28 |
| GB9305351D0 (en) | 1993-05-05 |
| HUT72984A (en) | 1996-06-28 |
| NO953638D0 (no) | 1995-09-15 |
| JPH08507781A (ja) | 1996-08-20 |
| AU6215394A (en) | 1994-10-11 |
| PL310657A1 (en) | 1995-12-27 |
| SK113795A3 (en) | 1997-02-05 |
| CN1121314A (zh) | 1996-04-24 |
| WO1994021302A1 (en) | 1994-09-29 |
| FI954326A (fi) | 1995-10-11 |
| NO953638L (no) | 1995-09-15 |
| CZ237195A3 (en) | 1996-05-15 |
| EP0689462A1 (en) | 1996-01-03 |
| AU695529B2 (en) | 1998-08-13 |
| FI954326A0 (fi) | 1995-09-14 |
| CA2158359A1 (en) | 1994-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |