KR950704251A - 프롤릴 엔도펩티다아제 억제 활성을 갖는 화합물 및 그 약학적 용도(compound with prolyl endopeptdase inhibitor activity and pharmaceutical use thereof) - Google Patents
프롤릴 엔도펩티다아제 억제 활성을 갖는 화합물 및 그 약학적 용도(compound with prolyl endopeptdase inhibitor activity and pharmaceutical use thereof)Info
- Publication number
- KR950704251A KR950704251A KR1019950702031A KR19950702031A KR950704251A KR 950704251 A KR950704251 A KR 950704251A KR 1019950702031 A KR1019950702031 A KR 1019950702031A KR 19950702031 A KR19950702031 A KR 19950702031A KR 950704251 A KR950704251 A KR 950704251A
- Authority
- KR
- South Korea
- Prior art keywords
- endopeptdase
- prolyl
- compound
- pharmaceutical use
- inhibitor activity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33389992 | 1992-11-20 | ||
| JP92-333899 | 1992-11-20 | ||
| JP8977593 | 1993-04-16 | ||
| JP93-89775 | 1993-04-16 | ||
| PCT/JP1993/001687 WO1994012474A1 (en) | 1992-11-20 | 1993-11-17 | Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950704251A true KR950704251A (ko) | 1995-11-17 |
| KR0165704B1 KR0165704B1 (ko) | 1999-01-15 |
Family
ID=26431188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950702031A KR0165704B1 (ko) | 1992-11-20 | 1993-11-17 | 프롤릴 엔도펩티다아제 억제 활성을 갖는 화합물 및 그 약학적 용도 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5536737A (ko) |
| EP (1) | EP0670309A1 (ko) |
| KR (1) | KR0165704B1 (ko) |
| CA (1) | CA2149892C (ko) |
| WO (1) | WO1994012474A1 (ko) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0831920A4 (en) * | 1995-06-06 | 2003-03-19 | Athena Neurosciences Inc | NOVEL CATHEPSIN AND METHODS AND COMPOSITIONS FOR INHIBITING CATHEPSIN |
| US6642261B2 (en) | 1997-11-21 | 2003-11-04 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6096782A (en) * | 1996-11-22 | 2000-08-01 | Athena Neurosciences, Inc. | N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| DE69733148T2 (de) * | 1996-12-02 | 2006-02-02 | Merck Sharp & Dohme Ltd., Hoddesdon | Die verwendung von nk-1 rezeptorantagonisten für die behandlung von kognitiven störungen |
| HUP9700442A1 (hu) * | 1997-02-14 | 1999-09-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Gyűrűs amidszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk |
| US6271230B1 (en) | 1997-12-01 | 2001-08-07 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating cognitive disorders |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| PL348661A1 (en) | 1998-06-03 | 2002-06-03 | Gpi Nil Holdings | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
| WO2000009125A1 (en) * | 1998-08-14 | 2000-02-24 | Gpi Nil Holdings, Inc. | Ureas and carbamates of n-heterocyclic carboxylic acids and isosteres for vision and memory disorders |
| US6121311A (en) * | 1999-04-28 | 2000-09-19 | Japan Tobacco Inc. | Method for treating cocainism |
| US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| ATE319712T1 (de) | 1999-12-21 | 2006-03-15 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
| DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| WO2006058720A2 (en) | 2003-11-03 | 2006-06-08 | Probiodrug Ag | Novel compounds for the treatment of neurological disorders |
| US20050137142A1 (en) | 2003-11-03 | 2005-06-23 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| EP1713780B1 (en) | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| EP1760076A1 (en) | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| EP2178830A2 (en) * | 2007-07-10 | 2010-04-28 | Probiodrug AG | Novel compounds |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0651677B2 (ja) | 1985-12-23 | 1994-07-06 | サントリー株式会社 | ジペプチド誘導体及びその製法並びに用途 |
| JP2526084B2 (ja) | 1987-02-23 | 1996-08-21 | 小野薬品工業株式会社 | 新規なチアゾリジン誘導体 |
| JPH0670023B2 (ja) | 1987-08-08 | 1994-09-07 | キッセイ薬品工業株式会社 | チアゾリジン誘導体 |
| JPH0832704B2 (ja) | 1987-11-30 | 1996-03-29 | キッセイ薬品工業株式会社 | プロリルエンドペプチダーゼ阻害剤 |
| JPH0825995B2 (ja) | 1988-04-08 | 1996-03-13 | 小野薬品工業株式会社 | 複素環化合物 |
| JPH0662591B2 (ja) * | 1988-12-14 | 1994-08-17 | 株式会社ヤクルト本社 | 新規なチオプロリン誘導体 |
| EP0419683A4 (en) | 1989-04-13 | 1992-03-11 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
| WO1991018877A1 (fr) * | 1990-06-07 | 1991-12-12 | Zeria Pharmaceutical Co., Ltd. | Nouveau derive d'arylalcanoylamine et medicament contenant ce derive |
| JPH07108897B2 (ja) * | 1990-07-27 | 1995-11-22 | 日本たばこ産業株式会社 | 新規なプロリン誘導体 |
| JPH05186498A (ja) * | 1991-12-27 | 1993-07-27 | Japan Tobacco Inc | プロリン誘導体 |
| JPH05201970A (ja) * | 1992-01-24 | 1993-08-10 | Japan Tobacco Inc | 新規プロリン誘導体 |
-
1993
- 1993-11-17 EP EP94900278A patent/EP0670309A1/en not_active Withdrawn
- 1993-11-17 KR KR1019950702031A patent/KR0165704B1/ko not_active IP Right Cessation
- 1993-11-17 WO PCT/JP1993/001687 patent/WO1994012474A1/ja not_active Application Discontinuation
- 1993-11-17 CA CA002149892A patent/CA2149892C/en not_active Expired - Fee Related
- 1993-11-17 US US08/446,592 patent/US5536737A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5536737A (en) | 1996-07-16 |
| CA2149892C (en) | 1998-12-08 |
| WO1994012474A1 (en) | 1994-06-09 |
| EP0670309A1 (en) | 1995-09-06 |
| CA2149892A1 (en) | 1994-06-09 |
| KR0165704B1 (ko) | 1999-01-15 |
| EP0670309A4 (en) | 1995-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| N231 | Notification of change of applicant | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid | ||
| LAPS | Lapse due to unpaid annual fee |