KR950704002A - 모티프를 사용한 삼중 나선 복합체의 형성(formation of triple helix complexes using a novel motif) - Google Patents
모티프를 사용한 삼중 나선 복합체의 형성(formation of triple helix complexes using a novel motif) Download PDFInfo
- Publication number
- KR950704002A KR950704002A KR1019950702400A KR19950702400A KR950704002A KR 950704002 A KR950704002 A KR 950704002A KR 1019950702400 A KR1019950702400 A KR 1019950702400A KR 19950702400 A KR19950702400 A KR 19950702400A KR 950704002 A KR950704002 A KR 950704002A
- Authority
- KR
- South Korea
- Prior art keywords
- strand
- target sequence
- oligomer
- strands
- triple helix
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/152—Nucleic acids forming more than 2 strands, e.g. TFOs on a single-stranded target, e.g. fold-back TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98774692A | 1992-12-08 | 1992-12-08 | |
US07/987746 | 1992-12-08 | ||
PCT/US1993/011986 WO1994013326A1 (fr) | 1992-12-08 | 1993-12-08 | Formation de complexes a helice triple a l'aide d'un nouveau motif |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950704002A true KR950704002A (ko) | 1995-11-17 |
Family
ID=25533520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950702400A KR950704002A (ko) | 1992-12-08 | 1993-12-08 | 모티프를 사용한 삼중 나선 복합체의 형성(formation of triple helix complexes using a novel motif) |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0673260A4 (fr) |
JP (1) | JPH08504103A (fr) |
KR (1) | KR950704002A (fr) |
AU (1) | AU684774B2 (fr) |
CA (1) | CA2151263A1 (fr) |
IL (1) | IL107934A0 (fr) |
NZ (1) | NZ259223A (fr) |
WO (1) | WO1994013326A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6441130B1 (en) | 1991-05-24 | 2002-08-27 | Isis Pharmaceuticals, Inc. | Linked peptide nucleic acids |
US6451968B1 (en) | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
WO1994018835A1 (fr) * | 1993-02-19 | 1994-09-01 | Genta Incorporated | Traitement de la calvitie associee aux androgenes au moyen d'oligomeres antisens |
DE19842527A1 (de) * | 1998-09-18 | 2000-03-23 | Friedrich Schiller Uni Jena Bu | Verfahren zur Bildung tripelhelixbildender Oligomere und deren Verbindungen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2006008C (fr) * | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques |
US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5399676A (en) * | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
HUT66828A (en) * | 1991-03-27 | 1995-01-30 | Res Corp Technologies Inc | Single-stranded circular oligonucleotides |
-
1993
- 1993-12-08 KR KR1019950702400A patent/KR950704002A/ko not_active Application Discontinuation
- 1993-12-08 AU AU66540/94A patent/AU684774B2/en not_active Ceased
- 1993-12-08 IL IL10793493A patent/IL107934A0/xx unknown
- 1993-12-08 EP EP94903559A patent/EP0673260A4/fr not_active Withdrawn
- 1993-12-08 WO PCT/US1993/011986 patent/WO1994013326A1/fr not_active Application Discontinuation
- 1993-12-08 NZ NZ259223A patent/NZ259223A/en unknown
- 1993-12-08 JP JP6514408A patent/JPH08504103A/ja active Pending
- 1993-12-08 CA CA002151263A patent/CA2151263A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU684774B2 (en) | 1998-01-08 |
NZ259223A (en) | 1997-10-24 |
WO1994013326A1 (fr) | 1994-06-23 |
AU6654094A (en) | 1994-07-04 |
JPH08504103A (ja) | 1996-05-07 |
IL107934A0 (en) | 1994-04-12 |
EP0673260A1 (fr) | 1995-09-27 |
EP0673260A4 (fr) | 1999-04-14 |
CA2151263A1 (fr) | 1994-06-23 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |