KR950700895A - 2,3-디히드로-2,2,4,6,7- 펜타알킬-5-벤조푸라놀의 신규 유도체(Novel Derivatives of 2,3-Dihydro-2,2,4,6,7-Pentaalkyl-5-Benzofuranols) - Google Patents
2,3-디히드로-2,2,4,6,7- 펜타알킬-5-벤조푸라놀의 신규 유도체(Novel Derivatives of 2,3-Dihydro-2,2,4,6,7-Pentaalkyl-5-Benzofuranols)Info
- Publication number
- KR950700895A KR950700895A KR1019940703513A KR19940703513A KR950700895A KR 950700895 A KR950700895 A KR 950700895A KR 1019940703513 A KR1019940703513 A KR 1019940703513A KR 19940703513 A KR19940703513 A KR 19940703513A KR 950700895 A KR950700895 A KR 950700895A
- Authority
- KR
- South Korea
- Prior art keywords
- dihydro
- benzofuranols
- pentaalkyl
- novel derivatives
- free radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92400956 | 1992-04-06 | ||
| PCT/US1993/002107 WO1993020057A1 (en) | 1992-04-06 | 1993-03-10 | Novel derivatives of 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950700895A true KR950700895A (ko) | 1995-02-20 |
Family
ID=8211646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940703513A KR950700895A (ko) | 1992-04-06 | 1994-10-05 | 2,3-디히드로-2,2,4,6,7- 펜타알킬-5-벤조푸라놀의 신규 유도체(Novel Derivatives of 2,3-Dihydro-2,2,4,6,7-Pentaalkyl-5-Benzofuranols) |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0635009B1 (ko) |
| JP (1) | JP3246741B2 (ko) |
| KR (1) | KR950700895A (ko) |
| AT (1) | ATE158287T1 (ko) |
| AU (1) | AU670433B2 (ko) |
| CA (1) | CA2132829C (ko) |
| DE (1) | DE69314022T2 (ko) |
| DK (1) | DK0635009T3 (ko) |
| ES (1) | ES2110602T3 (ko) |
| FI (1) | FI944655A (ko) |
| GR (1) | GR3025577T3 (ko) |
| HU (1) | HUT68926A (ko) |
| IL (1) | IL105318A (ko) |
| MX (1) | MX9301950A (ko) |
| NO (1) | NO943726L (ko) |
| NZ (1) | NZ251134A (ko) |
| TW (1) | TW226371B (ko) |
| WO (1) | WO1993020057A1 (ko) |
| ZA (1) | ZA932327B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510373A (en) * | 1992-04-06 | 1996-04-23 | Merrell Pharmaceuticals Inc. | Cardioprotective agents |
| US5545660A (en) * | 1992-04-07 | 1996-08-13 | Merrell Pharmaceuticals Inc. | Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans |
| TW393475B (en) * | 1992-10-16 | 2000-06-11 | Chugai Pharmaceutical Co Ltd | 4-alkoxyl-2,6-di-t-butyl phenol derivatives |
| IT1256264B (it) * | 1992-12-31 | 1995-11-29 | Lifegroup Spa | N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione |
| CA2215105A1 (en) * | 1995-03-10 | 1996-09-19 | Hoechst Marion Roussel, Inc. | Novel process for preparing 2,3-dihydro-benzofuranol derivatives |
| US6140309A (en) * | 1996-03-12 | 2000-10-31 | University Of South Florida | Vasoactive effects and free radical generation by β-amyloid peptides |
| WO2004041201A2 (en) * | 2002-11-01 | 2004-05-21 | Viropharma Incorporated | Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases |
| WO2004092153A1 (ja) * | 2003-04-14 | 2004-10-28 | Nippon Soda Co. Ltd. | ジアミン誘導体、製造法及び抗酸化薬 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
| JP2855340B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | ２―置換クマラン誘導体 |
| IT1229482B (it) * | 1988-08-01 | 1991-09-03 | Foscama Biomed Chim Farma | Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici. |
| IT1231341B (it) * | 1989-08-18 | 1991-11-28 | Foscama Biomed Chim Farma | 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche. |
| US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
| TW199152B (ko) * | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd |
-
1993
- 1993-03-10 JP JP51745293A patent/JP3246741B2/ja not_active Expired - Fee Related
- 1993-03-10 WO PCT/US1993/002107 patent/WO1993020057A1/en active IP Right Grant
- 1993-03-10 NZ NZ251134A patent/NZ251134A/en unknown
- 1993-03-10 DE DE69314022T patent/DE69314022T2/de not_active Expired - Fee Related
- 1993-03-10 DK DK93907336.7T patent/DK0635009T3/da active
- 1993-03-10 EP EP93907336A patent/EP0635009B1/en not_active Expired - Lifetime
- 1993-03-10 HU HU9402864A patent/HUT68926A/hu unknown
- 1993-03-10 ES ES93907336T patent/ES2110602T3/es not_active Expired - Lifetime
- 1993-03-10 AT AT93907336T patent/ATE158287T1/de not_active IP Right Cessation
- 1993-03-10 CA CA002132829A patent/CA2132829C/en not_active Expired - Fee Related
- 1993-03-10 AU AU37976/93A patent/AU670433B2/en not_active Ceased
- 1993-03-31 ZA ZA932327A patent/ZA932327B/xx unknown
- 1993-04-01 TW TW082102444A patent/TW226371B/zh active
- 1993-04-05 IL IL105318A patent/IL105318A/en not_active IP Right Cessation
- 1993-04-05 MX MX9301950A patent/MX9301950A/es unknown
-
1994
- 1994-10-05 KR KR1019940703513A patent/KR950700895A/ko not_active IP Right Cessation
- 1994-10-05 NO NO943726A patent/NO943726L/no unknown
- 1994-10-05 FI FI944655A patent/FI944655A/fi unknown
-
1997
- 1997-12-03 GR GR970403227T patent/GR3025577T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3025577T3 (en) | 1998-03-31 |
| IL105318A0 (en) | 1993-08-18 |
| TW226371B (ko) | 1994-07-11 |
| JP3246741B2 (ja) | 2002-01-15 |
| CA2132829A1 (en) | 1993-10-14 |
| FI944655A0 (fi) | 1994-10-05 |
| EP0635009B1 (en) | 1997-09-17 |
| HUT68926A (en) | 1995-08-28 |
| DE69314022T2 (de) | 1998-02-12 |
| CA2132829C (en) | 1999-01-26 |
| NZ251134A (en) | 1997-06-24 |
| WO1993020057A1 (en) | 1993-10-14 |
| IL105318A (en) | 1998-04-05 |
| ATE158287T1 (de) | 1997-10-15 |
| MX9301950A (es) | 1993-10-01 |
| DE69314022D1 (de) | 1997-10-23 |
| ES2110602T3 (es) | 1998-02-16 |
| EP0635009A1 (en) | 1995-01-25 |
| AU3797693A (en) | 1993-11-08 |
| DK0635009T3 (da) | 1997-10-06 |
| AU670433B2 (en) | 1996-07-18 |
| FI944655A (fi) | 1994-10-05 |
| JPH08503922A (ja) | 1996-04-30 |
| NO943726D0 (no) | 1994-10-05 |
| NO943726L (no) | 1994-12-06 |
| ZA932327B (en) | 1993-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| J201 | Request for trial against refusal decision | ||
| B701 | Decision to grant | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20031001 Year of fee payment: 4 |
|
| LAPS | Lapse due to unpaid annual fee |