KR950029254A - 신규한 생리 활성물질 엠알-387 에이(mr-387a), 엠알-387 비(mr-387b) 및 그의 제조방법 - Google Patents

신규한 생리 활성물질 엠알-387 에이(mr-387a), 엠알-387 비(mr-387b) 및 그의 제조방법 Download PDF

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KR950029254A
KR950029254A KR1019940009469A KR19940009469A KR950029254A KR 950029254 A KR950029254 A KR 950029254A KR 1019940009469 A KR1019940009469 A KR 1019940009469A KR 19940009469 A KR19940009469 A KR 19940009469A KR 950029254 A KR950029254 A KR 950029254A
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preparation
ratio
bioactive substance
novel bioactive
aminopeptidase
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KR0155403B1 (ko
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고영희
서영배
전효곤
정명철
이호재
이충환
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김은영
한국과학기술연구원
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 아미노펩티다제 M저해작용 및 면역증강 작용을 나타내는 신규한 아미노펩티다제 M 저해물질 MR―387A, MR―387B 및 이들의 염과 이들의 제조방법에 관한 것이다.

Description

신규한 생리 활성물질 엠암―387에이(MR―387A), 엠알―387비(MR―387B) 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 브롬화 칼륨(KBr)정내에서 MR―387A의 적외선 흡수 스펙트럼을 나타낸 그래프이다. 제2도는 MR―387A의 중수(D2O)용액에서 300MHz 수소 핵자기 공명 스펙트럼을 나타낸 그래프이다. 제3도는 브롬화 칼륨(KBr)정내에서 MR―387B의 적외선 흡수스펙트럼을 나타낸 그래프이다. 제4도는 MR―387B의 증수(D2O)용액에서 300MHz 수소 핵자기 공명 스펙트럼을 나타낸 그래프이다. 제5도는 MR―387A와 MR―387B를 6N 염산용액으로 48시간 가수분해한 후 아미노산 자동 분석기를 이용하여 분자내 아미노산조성을 분석한 결과이다.

Claims (5)

  1. 하기 일반식의 화합물 및 이의 염;
    상기식에서, R은 하이드록시프롤린 또는 프롤린이다.
  2. 제1항에 있어서, R이 하이드록시프롤린인 하기 구조식의 화합물(MR―387A);
  3. 제1항에 있어서, R이 프롤린인 하기 구조식의 화합물(MR―387B);
  4. 스트렙토미세스(Streptomyces) 속 SL―387균주(기탁번호 : KCTC0102BP)를 적당한 배지에서 배양하여 그 배양액으로 부터 MR―387A 또는 MR―387B를 단리하는 것을 특징으로 하는 아미노펩티다제 M 저해물질인 MR―387A 또는 MR―387B의 제조방법.
  5. 아미노펩티다제 M 저해물질 MR―387A 또는 MR―387B를 생산하는 스트렙토미세스(Streptomyces) 속 SL―387균주 (기탁번호 : KCTC0102BP).
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019940009469A 1994-04-30 1994-04-30 신규한 생리 활성 물질 엠알-387 에이, 엠알-387 비 및 그의 제조방법 KR0155403B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940009469A KR0155403B1 (ko) 1994-04-30 1994-04-30 신규한 생리 활성 물질 엠알-387 에이, 엠알-387 비 및 그의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940009469A KR0155403B1 (ko) 1994-04-30 1994-04-30 신규한 생리 활성 물질 엠알-387 에이, 엠알-387 비 및 그의 제조방법

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KR950029254A true KR950029254A (ko) 1995-11-22
KR0155403B1 KR0155403B1 (ko) 1998-10-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100431573B1 (ko) * 2002-03-12 2004-05-17 한국해양연구원 방선균 유래의 신규 생리 활성 물질, 이의 추출 방법 및이를 포함하는 약학적 조성물

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102691292B1 (ko) 2021-11-22 2024-08-05 강윤수 세탁기용 다기능 열풍 건조시스템
KR20240027266A (ko) 2022-08-23 2024-03-04 강윤수 균등한 열풍 공급분사가 가능하면서 습한 배기의 효과적 배출이 가능한 세탁기용 열풍건조시스템

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100431573B1 (ko) * 2002-03-12 2004-05-17 한국해양연구원 방선균 유래의 신규 생리 활성 물질, 이의 추출 방법 및이를 포함하는 약학적 조성물

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