KR950008494A - 나프톡사진 - Google Patents
나프톡사진 Download PDFInfo
- Publication number
- KR950008494A KR950008494A KR1019940021968A KR19940021968A KR950008494A KR 950008494 A KR950008494 A KR 950008494A KR 1019940021968 A KR1019940021968 A KR 1019940021968A KR 19940021968 A KR19940021968 A KR 19940021968A KR 950008494 A KR950008494 A KR 950008494A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- formula
- compound
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
본 발명은 하기 일반식(I)의 화합물 및 그 제조방법에 관한 것이다.
상기식에서, R1, R2및 R3는 제1항에서 정의된 바와 동일하다. 일반식(I)의 화합물은 약물로서 사용될 수 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 유리 염기 또는 산 부가염 형태의 하기 일반식(I)의 화합물 :상기식에서, R1은 (C1-4)알킬, 이중결합이 질소원자에 대한 α-위치에 존재하지 않는 (C3-6)알케닐 또는 (C3-7)시클로알킬 (C1-2)알킬이고, R2는 (C1-4)알콕시, (C2-6)알케닐옥시 또는 (C3-7)시클로알킬 (C1-2)알콜시이고, R3는 (C1-4)알킬카르보닐, (C1-4)알킬, α-히드록시 (C1-4)알킬, (C2-5)알케닐, (C1-4)알콕시 (C1-4)알킬 또는 (C3-7)시클로알킬이다.
- 유리 염기 또는 산 부가염 형태의 (-)-(1'R, 4aR, 10aR)-3,4,4a,5,10,10a-헥사히드로-9-(1'-메톡시에틸)-6-메톡시-4-메틸-2H-나프트[2,3-b]-1,4-옥사진.
- 유리 염기 또는 생리적으로 허용가능한 산 부가염 형태의, 제1항 또는 제2항의 화합물을 약제학적 담체 또는 희석제와 함께 포함하는 약제학적 조성물.
- (a)하기 일반식(II)의 화합물을9-위치에서 아실화시켜 하기 일반식(Ib)의 화합물을 제조하거나, (b)하기 일반식(II)의 화합물을9-위치에서 알킬화시켜 하기 일반식(Ib)의 화합물을 제조하고 바람직하게는, 이렇게하여 수득된 하기 일반식(I)의 화합물을 그들의 산 부가염으로 전환시킴으로써, 제1항에서 정의된 하기 일반식(I)의 화합물을 제조하는 방법.상기식에서, R1, R2및 R3는 제1항에서 정의된 바와 동일하고, Ra 3은 (C1-4)알킬, 카르보닐이고 Rb 3는 (C1-4)일킬 α-히드록시(C1-4)알킬, (C2-5)알케닐 (C1-4)알콕시 (C1-4)알킬 또는 (C3-7)시클로알킬이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4329776.5 | 1993-09-03 | ||
DE4329776A DE4329776A1 (de) | 1993-09-03 | 1993-09-03 | Naphthoxazine, ihre Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950008494A true KR950008494A (ko) | 1995-04-17 |
Family
ID=6496759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940021968A KR950008494A (ko) | 1993-09-03 | 1994-09-01 | 나프톡사진 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0641787A1 (ko) |
JP (1) | JPH07165736A (ko) |
KR (1) | KR950008494A (ko) |
CN (1) | CN1105998A (ko) |
AU (1) | AU7164394A (ko) |
CA (1) | CA2117656A1 (ko) |
CZ (1) | CZ211094A3 (ko) |
DE (1) | DE4329776A1 (ko) |
FI (1) | FI944012A (ko) |
HU (1) | HUT71117A (ko) |
IL (1) | IL110833A0 (ko) |
NO (1) | NO943230L (ko) |
PL (1) | PL304878A1 (ko) |
RU (1) | RU94032148A (ko) |
SK (1) | SK104894A3 (ko) |
ZA (1) | ZA946769B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
CA2740873C (en) | 2008-10-17 | 2019-09-10 | Wisconsin Alumni Research Foundation | Method of making biologically active alpha-beta peptides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU193979B (en) * | 1984-06-12 | 1987-12-28 | Sandoz Ag | Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them |
HU214591B (hu) * | 1989-12-14 | 1998-04-28 | Novartis Ag. | Eljárás egy naftoxazinszármazék malonátsójának és az ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására |
-
1993
- 1993-09-03 DE DE4329776A patent/DE4329776A1/de not_active Withdrawn
-
1994
- 1994-08-30 EP EP94810493A patent/EP0641787A1/en not_active Withdrawn
- 1994-09-01 FI FI944012A patent/FI944012A/fi unknown
- 1994-09-01 IL IL11083394A patent/IL110833A0/xx unknown
- 1994-09-01 KR KR1019940021968A patent/KR950008494A/ko not_active Application Discontinuation
- 1994-09-01 NO NO943230A patent/NO943230L/no unknown
- 1994-09-01 AU AU71643/94A patent/AU7164394A/en not_active Abandoned
- 1994-09-01 CZ CZ942110A patent/CZ211094A3/cs unknown
- 1994-09-02 HU HU9402534A patent/HUT71117A/hu unknown
- 1994-09-02 JP JP6209596A patent/JPH07165736A/ja active Pending
- 1994-09-02 PL PL94304878A patent/PL304878A1/xx unknown
- 1994-09-02 SK SK1048-94A patent/SK104894A3/sk unknown
- 1994-09-02 CN CN94115647A patent/CN1105998A/zh active Pending
- 1994-09-02 ZA ZA946769A patent/ZA946769B/xx unknown
- 1994-09-02 CA CA002117656A patent/CA2117656A1/en not_active Abandoned
- 1994-09-02 RU RU94032148/04A patent/RU94032148A/ru unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07165736A (ja) | 1995-06-27 |
FI944012A0 (fi) | 1994-09-01 |
HUT71117A (en) | 1995-11-28 |
FI944012A (fi) | 1995-03-04 |
RU94032148A (ru) | 1996-07-10 |
NO943230L (no) | 1995-03-06 |
CN1105998A (zh) | 1995-08-02 |
CZ211094A3 (en) | 1995-03-15 |
AU7164394A (en) | 1995-03-16 |
ZA946769B (en) | 1996-03-04 |
SK104894A3 (en) | 1995-05-10 |
NO943230D0 (no) | 1994-09-01 |
HU9402534D0 (en) | 1994-10-28 |
EP0641787A1 (en) | 1995-03-08 |
IL110833A0 (en) | 1994-11-28 |
PL304878A1 (en) | 1995-03-06 |
DE4329776A1 (de) | 1995-03-09 |
CA2117656A1 (en) | 1995-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |