KR950007801A - Medical devices prone to disintegration - Google Patents

Abstract

The present invention provides medical devices comprised of ionically crosslinked polymer, especially, stents, catheter or cannula components, plugs, and constrictors. The medical devices of the present invention are prepared by treatment of ionically crosslinkable polymer compositions with crosslinking ion compositions to provide ionically crosslinked materials. An important aspect of the present invention is that these medical devices can be disintegrated in-vivo at a desired time through the exposure of the medical device to a chemical trigger which generally is described as an agent that acts to displace the crosslinking ion in the ionically crosslinked material through binding or simple replacement with a non-crosslinking ion.

Description

Medical devices prone to disintegration

Since this is an open matter, no full text was included.

Claims (26)

A medical device comprising at least one member selected from the group consisting of stents, catheter or cannula components, plugs and constrictors, and ion crosslinked polymers. The medical device of claim 1, wherein the ion crosslinked polymer comprises one or more polymers made from one or more ion crosslinkable polymers selected from the group consisting of carboxyl, sulfate and amine functionalized polymers. The medical device of claim 1, wherein the ion crosslinked polymer comprises one or more polymers made from one or more polysaccharides. The medical device of claim 1, wherein the ion crosslinked polymer comprises one or more polymers made from one or more ion crosslinkable anionic polymers. The medical device of claim 1, wherein the ion crosslinked polymer comprises one or more polymers made from one or more ion crosslinkable cationic polymers. The method of claim 4, wherein the ion crosslinked anionic polymer is selected from the group consisting of polyacrylic acid, polydeacrylic acid, alginic acid, pectonic acid, carboxymethyl cellulose, haaruronic acid, heparin, carboxymethyl starch, carboxymethyl textane, heparin sulfate and A medical device comprising at least one polymer prepared from at least one ion crosslinkable polymer selected from the group consisting of chondroitin sulfate, and salts thereof. 6. The medical treatment of claim 5 wherein the ionic crosslinked cationic polymer comprises at least one polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine comprising at least one polymer prepared from ionic crosslinkable polymers. Device. The medical device of claim 1, wherein the ion crosslinked polymer comprises one or more cations and crosslinked by crosslinking ions. The medical device of claim 8, wherein the at least one cation is selected from the group consisting of calcium, magnesium, barium, strontium, saxophonium, batilium, aluminum, iron, copper, cobalt, lead and silver ions. The medical device of claim 1, wherein the ion crosslinked polymer is crosslinked by crosslinking ions comprising one or more anions. The medical device of claim 10, wherein the at least one anion is selected from the group consisting of phosphate, citrate, borate, soxate, maleate, adipate and oxalate ions. The medical device of claim 1, further comprising one or more body fluids selected from the group consisting of urine, bile, stool, and serous fluid. The medical device of claim 1, further comprising a reagent to substitute crosslinking ions. The method of claim 13, wherein the reagent for replacing the crosslinking ions is ethylene diamine tetra acetic acid, ethylene diamine tetraacetate, citrate, organic phosphate, inorganic phosphate. A medical device comprising at least one member selected from the group consisting of trisodium carboxymethyloxysuccinate, nitrilotriacetic acid, maleic acid, oxalate, polyacrylic acid, sodium, potassium, calcium and magnesium. 15. The medical device of claim 14, wherein the inorganic phosphate is selected from the group consisting of pentasodium tripolyphosphate, mono- and dipyritic potassium phosphate, nat prop propphosphate and phosphoric acid. Dissolving the in vivo medical device with at least one chemical trigger. The method of claim 16, wherein the in vivo medical device comprises a crosslinked polymer followed by the chemical trigger comprising one or more reagents to replace the crosslinking ions. A method of medical treatment of humans and animals comprising introducing a medical device of any one of claims 1 to 15 into humans and animals. Medically comprising the ion crosslinked polymer with one or more members selected from the group consisting of stents, catheters or cannula components, plugs and shrinkages by crosslinking the polymer by treating the ion crosslinkable polymer with crosslinking ions. A method of medical treatment of humans and animals comprising the manufacture of a device and introduction into humans and animals. 20. The method of claim 18 or 19, further comprising disintegrating the medical device with a chemical trigger. 21. The method of claim 20, wherein said chemical trigger comprises one or more reagents to replace cross-linking ions. A medical device comprising an ionic crosslinked polymer hydrogel having a water content of less than 90%. And modifying the medical device comprising the ion crosslinked polymer at a temperature of about 40 ° C. or greater. Introducing an ion crosslinkable polymer through a die to shape a tube, simultaneously pumping a solution comprising crosslinking ions through the shaped tube, and solution forming the tube containing crosslinking ions from the die Extruding into and then optionally heat treating the shaped tube. Use of a medical device comprising an ionic crosslinked polymer in a human or animal system selected from the group consisting of gastrointestinal tract, genitourinary, cardiovascular, lymphatic, otolaryngological, ocular, nerve, cortical and muscular systems. A medical device comprising an ion crosslinked polymer that can be sterilized at a temperature of 121 ° C. or higher. ※ Note: The disclosure is based on the initial application.