KR950000650A - 트리요오도벤젠 유도체의 제조방법 - Google Patents

트리요오도벤젠 유도체의 제조방법 Download PDF

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Publication number
KR950000650A
KR950000650A KR1019930010109A KR930010109A KR950000650A KR 950000650 A KR950000650 A KR 950000650A KR 1019930010109 A KR1019930010109 A KR 1019930010109A KR 930010109 A KR930010109 A KR 930010109A KR 950000650 A KR950000650 A KR 950000650A
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South Korea
Prior art keywords
formula
general formula
derivative
protected
aniline derivative
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KR1019930010109A
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English (en)
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KR970001536B1 (ko
Inventor
조정혁
오창현
류재천
Original Assignee
김은영
한국과학기술연구원
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Priority to KR1019930010109A priority Critical patent/KR970001536B1/ko
Publication of KR950000650A publication Critical patent/KR950000650A/ko
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Publication of KR970001536B1 publication Critical patent/KR970001536B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 X선 조영제로서 사용되는 일반식(Ⅰ)의 트리요오드벤젠 유도체의 제조방법이 제공된다.
본 발명의 제조방법은 일반식(Ⅱ)의 아닐린 유도체를 유기염기 존재하에 아세틸 화합물과 반응시켜 히드록시기가 보호된 일반식(Ⅲ)의 아닐린 유도체를 얻은 다음, 유기용매에서 아세틸기로 보호된 일반식(Ⅳ)의 α-히드록시 카르복실산 또는 그의 염화물과 반응시키고, 얻어진 일반식(Ⅳ)의 아실화물에 구아니딘을 촉매량 가하는 것으로 이루어진다.
상기식에서의 R1, R2는 각각 독립적으로 수소, 메틸, 저급알킬(C1-C6)이다.

Description

트리요오드벤젠 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(II)의 아닐린 유도체를 유기염기 존재하에 아세틸 화합물과 반응시켜 히드록시기가 보호된 일반식(III)의 아닐린유도체를 얻은 다음, 유기용매에서 아세틸기로 보호된 일반식(IV)의 α-히드록시카르복실산 또는 그의 염화물과 반응시키고, 얻어진 일반식(V)의 아실화물에 구아니딘을 촉매량 가하는 것으로 이루어진 일반식(I)의 트리요오도벤젠 유도체의 제조방법.
    상기식에서의 R1, R2는 각각 독립적으로 수소, 메틸, 저급알킬(C1-C6)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930010109A 1993-06-04 1993-06-04 트리요오도벤젠 유도체의 제조방법 KR970001536B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930010109A KR970001536B1 (ko) 1993-06-04 1993-06-04 트리요오도벤젠 유도체의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930010109A KR970001536B1 (ko) 1993-06-04 1993-06-04 트리요오도벤젠 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR950000650A true KR950000650A (ko) 1995-01-03
KR970001536B1 KR970001536B1 (ko) 1997-02-11

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Application Number Title Priority Date Filing Date
KR1019930010109A KR970001536B1 (ko) 1993-06-04 1993-06-04 트리요오도벤젠 유도체의 제조방법

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KR970001536B1 (ko) 1997-02-11

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