KR930017580A - 혈액 순환의 중단후 근육 손상을 치료하기 위한 키산틴 유도체의 용도 - Google Patents
혈액 순환의 중단후 근육 손상을 치료하기 위한 키산틴 유도체의 용도 Download PDFInfo
- Publication number
- KR930017580A KR930017580A KR1019930002426A KR930002426A KR930017580A KR 930017580 A KR930017580 A KR 930017580A KR 1019930002426 A KR1019930002426 A KR 1019930002426A KR 930002426 A KR930002426 A KR 930002426A KR 930017580 A KR930017580 A KR 930017580A
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- formula
- hydroxy
- chianthine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000017531 blood circulation Effects 0.000 title claims abstract 7
- 208000029549 Muscle injury Diseases 0.000 title claims abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 19
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 4
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims abstract 3
- 238000011282 treatment Methods 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- -1 5-hydroxy-5-methylhexyl Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000107 myocyte Anatomy 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940075420 xanthine Drugs 0.000 claims 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4205424.9 | 1992-02-22 | ||
| DE4205424 | 1992-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930017580A true KR930017580A (ko) | 1993-09-20 |
Family
ID=6452327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930002426A Withdrawn KR930017580A (ko) | 1992-02-22 | 1993-02-22 | 혈액 순환의 중단후 근육 손상을 치료하기 위한 키산틴 유도체의 용도 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0557876B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP3193800B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR930017580A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE146078T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU658979B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2089959A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE59304710D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0557876T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2096115T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3022183T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT64472A (cg-RX-API-DMAC7.html) |
| TW (1) | TW288977B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA931184B (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3792266B2 (ja) * | 1994-06-16 | 2006-07-05 | 森精機興産株式会社 | 工作機械の熱変位補正方法及びその装置 |
| DE19540798A1 (de) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel |
| US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
| US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
| US20070105878A1 (en) * | 2005-10-03 | 2007-05-10 | Andrew Reaume | Purine formulations and methods for managing disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608236A5 (cg-RX-API-DMAC7.html) * | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| GB8621870D0 (en) * | 1986-09-11 | 1986-10-15 | Beecham Group Plc | Active compounds |
| EP0484785B1 (en) * | 1990-11-07 | 1996-05-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of xanthines for the preparation of a medicament effective for inhibiting the replication of human retroviruses |
-
1993
- 1993-02-17 TW TW082101087A patent/TW288977B/zh active
- 1993-02-17 DK DK93102450.9T patent/DK0557876T3/da active
- 1993-02-17 AT AT93102450T patent/ATE146078T1/de not_active IP Right Cessation
- 1993-02-17 EP EP93102450A patent/EP0557876B1/de not_active Expired - Lifetime
- 1993-02-17 ES ES93102450T patent/ES2096115T3/es not_active Expired - Lifetime
- 1993-02-17 DE DE59304710T patent/DE59304710D1/de not_active Expired - Lifetime
- 1993-02-19 AU AU33761/93A patent/AU658979B2/en not_active Ceased
- 1993-02-19 ZA ZA931184A patent/ZA931184B/xx unknown
- 1993-02-19 JP JP02951693A patent/JP3193800B2/ja not_active Expired - Lifetime
- 1993-02-19 CA CA002089959A patent/CA2089959A1/en not_active Abandoned
- 1993-02-22 HU HU9300476A patent/HUT64472A/hu unknown
- 1993-02-22 KR KR1019930002426A patent/KR930017580A/ko not_active Withdrawn
-
1996
- 1996-12-30 GR GR960403651T patent/GR3022183T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9300476D0 (en) | 1993-05-28 |
| TW288977B (cg-RX-API-DMAC7.html) | 1996-10-21 |
| JP3193800B2 (ja) | 2001-07-30 |
| AU3376193A (en) | 1993-08-26 |
| EP0557876A1 (de) | 1993-09-01 |
| HUT64472A (en) | 1994-01-28 |
| CA2089959A1 (en) | 1993-08-23 |
| ZA931184B (en) | 1993-09-16 |
| DE59304710D1 (de) | 1997-01-23 |
| DK0557876T3 (da) | 1997-05-26 |
| ATE146078T1 (de) | 1996-12-15 |
| ES2096115T3 (es) | 1997-03-01 |
| GR3022183T3 (en) | 1997-03-31 |
| AU658979B2 (en) | 1995-05-04 |
| JPH069634A (ja) | 1994-01-18 |
| EP0557876B1 (de) | 1996-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0513104T3 (da) | Anvendelse af et alfa-tocopherolphosphat eller et af dets derivater til fremstilling af kosmetiske, dermatologiske eller farmaceutiske præparater, og således opnåede præparater | |
| KR940005270A (ko) | 뼈 손실 예방에 유용한 벤조티오펜 | |
| KR950010890A (ko) | 폐경기 증후군의 치료방법 | |
| KR950031068A (ko) | 골다공증의 복합 치료 | |
| KR950000663A (ko) | 트리테르펜 유도체 및 이를 함유하는 엔도텔린-수용체 길항물질 | |
| KR930001911A (ko) | 두개-뇌 외상후의 이차 신경 세포 손상 및 기능 장애를 치료하기 위한 크산틴 유도체의 용도 | |
| AU625886B2 (en) | New oxazolopyridine derivatives, process for preparing them and pharmaceutical compositions containing them | |
| KR910019623A (ko) | 상승병용을 이용한 안고혈압 치료 | |
| BR9916046A (pt) | Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus herpes e para tratamento de um paciente que sofra de uma infecção do vìrus herpes | |
| DK0488928T3 (da) | Pharmaceutiske formuleringer, der indeholder en blanding af højere, primære, alifatiske alkoholer, til behandling af hyperc | |
| AU8699891A (en) | Use of xanthines for the preparation of a medicament effective for inhibiting the replication of human retroviruses | |
| RU98100111A (ru) | Активирующая остеогенез фармацевтическая композиция | |
| KR950016753A (ko) | 벤조[쥐(g)]퀴놀린의 신규의 사용 방법 | |
| AU3376193A (en) | The use of xanthine derivatives for the treatment of muscle damage after interruption of the blood circulation | |
| KR940013503A (ko) | 동맥경화증의 예방 또는 치료용 약제학적 조성물 | |
| KR900701270A (ko) | 피리디닐메틸(술피닐 또는 티오)벤즈이미다졸을 사용한 인체 눈의 녹내장 및 관련 장해의 치료 방법 | |
| KR920021151A (ko) | 면역억제특성을 갖는 약제학적 조성물을 제조하기 위한 인지질 유도체의 용도 | |
| ES2107174T3 (es) | Derivados del etoposido, su procedimiento de preparacion, su utilizacion a titulo de medicamento y su utilizacion para la preparacion de un medicamento destinado al tratamiento anticanceroso. | |
| KR880013896A (ko) | 벤조푸로[3,2-c]퀴놀린 화합물 | |
| KR900015728A (ko) | 약제-내성 원생 동물 감염에 대한 치료에 있어서 방향족, 삼환식 화합물의 n-알킬아미노 유도체 | |
| MX9304313A (es) | Nuevos derivados de acido difosfonico, que contienen grupos amidina aciclicos, procedimiento para supreparacion y composiciones farmaceuticas que los contienen. | |
| KR910002455A (ko) | 아크릴산 유도체를 함유하는 제약 조성물 및 의약으로서 이들의 사용 | |
| KR960703924A (ko) | 항바이러스제로서 신규한 벤조티오펜 유사체(Novel Benzothiophene Analogs as Antiviral Agents) | |
| KR930017906A (ko) | 술포닐벤질 치환 이미다조피리딘 | |
| KR910011258A (ko) | 녹내장의 치료방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19930222 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |