KR930001930A - 핵 자기공명 조영제 - Google Patents

핵 자기공명 조영제 Download PDF

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Publication number
KR930001930A
KR930001930A KR1019920012482A KR920012482A KR930001930A KR 930001930 A KR930001930 A KR 930001930A KR 1019920012482 A KR1019920012482 A KR 1019920012482A KR 920012482 A KR920012482 A KR 920012482A KR 930001930 A KR930001930 A KR 930001930A
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KR
South Korea
Prior art keywords
contrast agent
complex
paramagnetic metal
agent according
magnetic resonance
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KR1019920012482A
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English (en)
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KR100206039B1 (ko
Inventor
유지 하시구치
쿠미코 이와이
시게미 세리
스스무 콘도
마코토 아즈마
Original Assignee
도키 가츠유키
니혼 메디피직스 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Soft Magnetic Materials (AREA)

Abstract

내용 없음.

Description

핵 자기공명 조영제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는(디알데히드-스타치)-p-아미노벤질-DTPA-Gd(DAS-DTEN-Gd)용액 투여 직후 희생된 랫트의 심장이 있는 가슴부위의 횡단면을 나타내고 있는 핵자기공명 조영 사진이고,
제2도는 DAS-DTEN-Gd용액을 투여한 지 30분후 희생된 랫트의 심장이 있는 가슴부위의 횡단면을 나타내고 있는 핵자기공명 조영 사진이며,
제3도는 DTPA-Gd(MAGNEVIST)를 투여한 지 30분 후 희생된 랫트의 심장이 있는 가슴부위의 횡단면을 나타내고 있는 핵자기공명 조영 사진이다.

Claims (8)

  1. (1) 분자량이 500 내지 10,000인, 1 이상의 산화-분해된 구성 모노사카라이드를 가지는 디알데히드-사카라이드, (2) 디알데히드-사카라이드의 알데히드기에 화학적으로 결합된 1 이상의 착화제, 및 (3) 상기 착화합물제와 화학적으로 결합된 상자성 금속이온으로 이루어진 착화합물인 핵자기공명 조영제.
  2. 제1항에 있어서, 상기 착화합물의 혈중 지속시간은 혈중 반감기로서 0.5 내지 5시간인 것임을 특징으로 하는 조영재.
  3. 제2항에 있어서, 상기 착화합물의 구성 모노사카라이드는 D-글루코스인 것임을 특징으로 하는 조영제.
  4. 제2항에 있어서, 상기 착화합물에서 구성 모노사카라이드의 반복단위수는 3 내지 10인 것임을 특징으로 하는 조영제.
  5. 제2항에 있어서, 상기 착화합물의 착화제는 디에틸렌트리아민펜타아세트산 또는 1,4,7,10-테트라아자시클로도데칸-1,4,7,10-테트라아세트산의 유도체인 것임을 특징으로 하는 조영제.
  6. 제2항에 있어서, 상기 착화합물의 상자성 금속이온은 원자번호 57 내지 70인 란탄계 원소인 것임을 특징으로 하는 조영제.
  7. 제6항에 있어서, 상기 상자성 금속이온은 Gd 또는 Dy인 것임을 특징으로 하는 조영제.
  8. 제2항에 있어서, 상기 착화합물의 상자성 금속이온의 농도는 1×10-5내 지 1×10 몰/리터인 것임을 특징으로 하는 조영제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920012482A 1991-07-15 1992-07-14 핵자기공명 조영제 KR100206039B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP173743/1991 1991-07-15
JP3173743A JP2901787B2 (ja) 1991-07-15 1991-07-15 核磁気共鳴造影剤

Publications (2)

Publication Number Publication Date
KR930001930A true KR930001930A (ko) 1993-02-22
KR100206039B1 KR100206039B1 (ko) 1999-07-01

Family

ID=15966310

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920012482A KR100206039B1 (ko) 1991-07-15 1992-07-14 핵자기공명 조영제

Country Status (11)

Country Link
US (1) US5271929A (ko)
EP (1) EP0523572B1 (ko)
JP (1) JP2901787B2 (ko)
KR (1) KR100206039B1 (ko)
AT (1) ATE143606T1 (ko)
AU (1) AU651708B2 (ko)
CA (1) CA2073482C (ko)
DE (1) DE69214215T2 (ko)
DK (1) DK0523572T3 (ko)
ES (1) ES2094853T3 (ko)
GR (1) GR3021229T3 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ280272A (en) * 1994-10-21 1996-11-26 Nihon Mediphysics Co Ltd Diagnostic imaging agent comprising a metal ion and bifunctional ligand bonded to an amino- or dialdehyde- oligosaccharide
US5677382A (en) 1994-12-19 1997-10-14 Japan Synthetic Rubber Co., Ltd. Ethylene-α-olefin-non-conjugated diene copolymer rubber composition
EP1805188A4 (en) * 2004-09-30 2010-03-03 Mds Analytical Technologies Us COMPLEXES OF LUMINESCENT LANTHANIDES
SI2280720T1 (sl) 2008-03-27 2019-06-28 Purdue Research Foundation Sintetični peptidoglikani,ki vežejo kolagen, priprava in postopki uporabe
RS55823B1 (sr) 2011-05-24 2017-08-31 Symic Ip Llc Sintetički peptidoglikani koji vezuju hijaluronsku kiselinu, priprema i postupci upotrebe
KR20150130419A (ko) 2013-03-15 2015-11-23 시믹 바이오메디칼, 인크. 세포외 기질 결합성 합성 펩티도글리칸
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
US11529424B2 (en) 2017-07-07 2022-12-20 Symic Holdings, Inc. Synthetic bioconjugates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
AU6621586A (en) * 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
DE3701665A1 (de) * 1987-01-19 1988-07-28 Schering Ag Polymer-komplexe, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US4952393A (en) * 1987-04-02 1990-08-28 The General Hospital Corporation Organ infarct imaging with technetium labelled glucarate
US4965007A (en) * 1988-05-10 1990-10-23 Eastman Kodak Company Encapsulated superparamagnetic particles
US5094950A (en) * 1988-06-07 1992-03-10 Nihon Medi-Physics Co., Ltd. Diethylenetriamine pentaacetic acid derivatives
JPH04154729A (ja) * 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
US5143716A (en) * 1991-02-01 1992-09-01 Unger Evan C Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region

Also Published As

Publication number Publication date
AU651708B2 (en) 1994-07-28
CA2073482C (en) 2003-08-19
GR3021229T3 (en) 1997-01-31
DE69214215D1 (de) 1996-11-07
US5271929A (en) 1993-12-21
ATE143606T1 (de) 1996-10-15
JPH0525059A (ja) 1993-02-02
DK0523572T3 (da) 1996-11-18
EP0523572A1 (en) 1993-01-20
CA2073482A1 (en) 1993-01-16
AU1962692A (en) 1993-01-21
DE69214215T2 (de) 1997-03-06
ES2094853T3 (es) 1997-02-01
JP2901787B2 (ja) 1999-06-07
KR100206039B1 (ko) 1999-07-01
EP0523572B1 (en) 1996-10-02

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