KR920701175A - Method for preparing isoxazole derivatives - Google Patents

Method for preparing isoxazole derivatives

Info

Publication number
KR920701175A
KR920701175A KR1019910701137A KR910701137A KR920701175A KR 920701175 A KR920701175 A KR 920701175A KR 1019910701137 A KR1019910701137 A KR 1019910701137A KR 910701137 A KR910701137 A KR 910701137A KR 920701175 A KR920701175 A KR 920701175A
Authority
KR
South Korea
Prior art keywords
general formula
oxidation
lower alkoxy
producing
potassium
Prior art date
Application number
KR1019910701137A
Other languages
Korean (ko)
Other versions
KR940008746B1 (en
Inventor
모도아끼 다나까
유우이찌 하기와라
마꼬또 가지다니
미쯔기 야스모도
Original Assignee
고바야시 유끼오
다이호오 야꾸힌 고오교오 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고바야시 유끼오, 다이호오 야꾸힌 고오교오 가부시끼가이샤 filed Critical 고바야시 유끼오
Publication of KR920701175A publication Critical patent/KR920701175A/en
Application granted granted Critical
Publication of KR940008746B1 publication Critical patent/KR940008746B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for producing an isoxazole derivative of general formula (II), wherein R<1> and R<2> may be the same or different from each other and each represents hydrogen or lower alkoxy, and R<3> represents cyano or alkoxycarbonyl, by oxidizing an alpha , beta -unsaturated ketoxime derivative of general formula (I), wherein R<1>, R<2> and R<3> are as defined above. The isoxazole derivative (II) is useful as an intermediate for the production of (3,4-diaryl-isoxazol-5-yl)acetic acid derivatives useful as an antiinflammatory, analgesic and antipyretic.

Description

이소옥사졸 유도체의 제조방법Method for preparing isoxazole derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

일반식General formula (식중, R1및 R2는 동일 또는 상이하여 수소원자, 저급알콕시기, R3은 시아노기 또는 알콕시카르보닐기를 표시함.)으로 표시되는 α,β-불포화케토옥심 유도체를 산화하는 것을 특징으로 하는 일반식.Oxidizing α, β-unsaturated ketooxime derivatives represented by (wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkoxy group, R 3 represents a cyano group or an alkoxycarbonyl group) General formula. (식중, R1, R2및 R3은 상기와 같음.)으로 표시되는 이소옥사졸 유도체의 제조방법.(Wherein R 1 , R 2 and R 3 are the same as described above). 제1항에 있어서, R1및 R2가 저급알콕시기인 것을 특징으로 하는 이소옥사졸 유도체의 제조방법.The method for producing an isoxazole derivative according to claim 1, wherein R 1 and R 2 are lower alkoxy groups. 제1항에 있어서, 산화를 과망간산 칼륨, 이산화망간, 과요오드산 칼륨, 과요오드산나트륨, 4산화 류테늄, 4 아세트산납, 아세트산수은, 염화철(Ⅲ), 헥사시아노 철(Ⅲ)산 칼륨, 과산화수소수 또는 과아세트산의 산화제, 공기 또는 산소를 사용하는 산소산화 또는 유기전해산화로 행하는 것을 특징으로 하는 이소옥사졸 유도체의 제조방법.The method according to claim 1, wherein the oxidation is carried out by potassium permanganate, manganese dioxide, potassium periodate, sodium periodate, ruthenium tetraoxide, lead acetate, mercury acetate, iron chloride (III), potassium hexacyano iron (III), A method for producing isoxazole derivatives, which is carried out by oxygen oxidation or organic electrolysis oxidation using an oxidizing agent of hydrogen peroxide or peracetic acid, air or oxygen. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910701137A 1990-01-24 1991-01-22 Process for producing isoxazole derivative KR940008746B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP90-14239 1990-01-24
JP2014239A JP2796749B2 (en) 1990-01-24 1990-01-24 Method for producing isoxazole derivative
PCT/JP1991/000064 WO1991011443A1 (en) 1990-01-24 1991-01-22 Process for producing isoxazole derivative

Publications (2)

Publication Number Publication Date
KR920701175A true KR920701175A (en) 1992-08-11
KR940008746B1 KR940008746B1 (en) 1994-09-26

Family

ID=11855534

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910701137A KR940008746B1 (en) 1990-01-24 1991-01-22 Process for producing isoxazole derivative

Country Status (11)

Country Link
EP (1) EP0464218B1 (en)
JP (1) JP2796749B2 (en)
KR (1) KR940008746B1 (en)
AT (1) ATE126791T1 (en)
AU (1) AU623306B2 (en)
CA (1) CA2050345C (en)
DE (1) DE69112297T2 (en)
DK (1) DK0464218T3 (en)
ES (1) ES2080295T3 (en)
GR (1) GR3018088T3 (en)
WO (1) WO1991011443A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399577A (en) * 1991-05-01 1995-03-21 Taiho Pharmaceutical Co., Ltd. Isoxazole derivatives and salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1128526A (en) * 1979-10-05 1982-07-27 Cdc Life Sciences Inc. 3,4-diarylisoxazol-5-acetic acids
JPS6075471A (en) * 1983-10-03 1985-04-27 Sankyo Kasei Kogyo Kk Preparation of 3,4-diphenylisoxazol-5-acetic acid
JPH0675471A (en) * 1992-06-30 1994-03-18 Canon Inc Developing device and process cartridge using that

Also Published As

Publication number Publication date
CA2050345C (en) 1996-05-28
KR940008746B1 (en) 1994-09-26
DE69112297T2 (en) 1996-01-25
EP0464218A1 (en) 1992-01-08
JPH03220181A (en) 1991-09-27
EP0464218A4 (en) 1992-06-17
DK0464218T3 (en) 1995-09-25
DE69112297D1 (en) 1995-09-28
ES2080295T3 (en) 1996-02-01
AU7057791A (en) 1991-08-21
WO1991011443A1 (en) 1991-08-08
EP0464218B1 (en) 1995-08-23
ATE126791T1 (en) 1995-09-15
JP2796749B2 (en) 1998-09-10
GR3018088T3 (en) 1996-02-29
CA2050345A1 (en) 1991-07-25
AU623306B2 (en) 1992-05-07

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