KR970061880A - Method for preparing 2-sulfonylthiazole carboxylic acid derivative - Google Patents

Method for preparing 2-sulfonylthiazole carboxylic acid derivative Download PDF

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Publication number
KR970061880A
KR970061880A KR1019960038202A KR19960038202A KR970061880A KR 970061880 A KR970061880 A KR 970061880A KR 1019960038202 A KR1019960038202 A KR 1019960038202A KR 19960038202 A KR19960038202 A KR 19960038202A KR 970061880 A KR970061880 A KR 970061880A
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South Korea
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carboxylic acid
acid derivative
carried out
temperature
formula
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KR1019960038202A
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Korean (ko)
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KR100206535B1 (en
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류요섭
김성기
편승엽
전재훈
유성훈
김문정
조진호
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성재갑
주식회사 Lg 화학
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 하기 일반식(3)의 화합물을 염기의 존재하에서 가수분해 하여 일반식(4)의 2-술파닐티아졸 카르복실산 유도체를 생성시킨 후, 이를 용매의 존재하에서 산화시킴을 특징으로 하여, 하기 일반식(1)의 2-술포닐티아졸 카르복실산 유도체를 제조하는 방법에 관한 것이다.The present invention is characterized in that the compound of formula (3) is hydrolyzed in the presence of a base to produce a 2-sulfanylthiazole carboxylic acid derivative of formula (4), which is then oxidized in the presence of a solvent. The present invention relates to a method for producing the 2-sulfonylthiazole carboxylic acid derivative of the following general formula (1).

상기 식에서, R1은 C1-3직쇄 알킬기를 나타내고; R2는 C1-3알킬 또는 C1-3할로알킬을 나타내며, R3는 메틸 또는 에틸기를 나타낸다.Wherein R 1 represents a C 1-3 straight chain alkyl group; R 2 represents C 1-3 alkyl or C 1-3 haloalkyl, and R 3 represents a methyl or ethyl group.

Description

2-술포닐티아졸 카르복실산 유도체의 제조방법Method for preparing 2-sulfonylthiazole carboxylic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (9)

하기 일반식(3)의 화합물을 염기의 존재하에서 가수분해 하여 일반식(4)의 2-술파닐티아졸 카르복실산 유도체를 생성시킨 후, 이를 용매의 존재하에서 산화시킴을 특징으로 하여, 하기 일반식(1)의 2-술포닐티아졸 카르복실산 유도체를 제조하는 방법.The compound of formula (3) is hydrolyzed in the presence of a base to produce 2-sulfanylthiazole carboxylic acid derivative of formula (4), which is then oxidized in the presence of a solvent. A method for producing the 2-sulfonylthiazole carboxylic acid derivative of the general formula (1). 상기 식에서, R1은 C1-3직쇄 알킬기를 나타내고; R2는 C1-3알킬 또는 C1-3할로알킬을 나타내며, R3는 메틸 또는 에틸기를 나타낸다.Wherein R 1 represents a C 1-3 straight chain alkyl group; R 2 represents C 1-3 alkyl or C 1-3 haloalkyl, and R 3 represents a methyl or ethyl group. 제1항에 있어서, 염기가 수산화나트륨, 수산화칼륨 및 수산화리튬 중에서 선택된 1종 이상인 방법.The method of claim 1 wherein the base is at least one selected from sodium hydroxide, potassium hydroxide and lithium hydroxide. 제1항에 있어서, 가수분해를 0 내지 100℃의 온도에서 수행하는 방법.The process of claim 1 wherein the hydrolysis is carried out at a temperature of from 0 to 100 ° C. 제3항에 있어서, 가수분해를 25 내지 100℃의 온도에서 수행하는 방법.The process of claim 3 wherein the hydrolysis is carried out at a temperature of 25 to 100 ° C. 5. 제1항에 있어서, 산화제가 과산화수소수, 과산화유기산 및 옥손 중에서 선택된 1종 이상인 방법.The method of claim 1, wherein the oxidant is at least one selected from hydrogen peroxide water, organic peroxide acids, and oxone. 제1항에 있어서, 반응 용매가 메틸알콜, 에틸알콜, 이소프로필알콜, t-부틸알콜, 디옥신, 테트라하이드포푸란 및 물 중에서 선택된 1종 이상인 방법.The method of claim 1, wherein the reaction solvent is at least one selected from methyl alcohol, ethyl alcohol, isopropyl alcohol, t-butyl alcohol, dioxin, tetrahydrofuran and water. 제1항에 있어서, 상-전달 촉매로서 크라운 에테르 또는 유기 암모늄 화합물을 추가로 첨가하는 방법.The process of claim 1, wherein the crown ether or organic ammonium compound is further added as a phase-transfer catalyst. 제1항에 있어서, 산화 반응을 -20 내지 100℃의 온도에서 수행하는 방법.The process of claim 1 wherein the oxidation reaction is carried out at a temperature of -20 to 100 ° C. 제8항에 있어서, 산화 반응을 0 내지 80℃의 온도에서 수행하는 방법.The method of claim 8, wherein the oxidation reaction is carried out at a temperature of 0 to 80 ° C. 10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960038202A 1996-02-08 1996-09-04 Process for the preparation of 2-sulfonylthiazole carboxylic acid derivatives KR100206535B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960038202A KR100206535B1 (en) 1996-02-08 1996-09-04 Process for the preparation of 2-sulfonylthiazole carboxylic acid derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR101996003045 1996-02-08
KR19960003045 1996-02-08
KR96-3045 1996-02-08
KR1019960038202A KR100206535B1 (en) 1996-02-08 1996-09-04 Process for the preparation of 2-sulfonylthiazole carboxylic acid derivatives

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KR970061880A true KR970061880A (en) 1997-09-12
KR100206535B1 KR100206535B1 (en) 1999-07-01

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