KR830003481A - Method for preparing 6-fluoro-1,8-naphthyridine derivative - Google Patents

Method for preparing 6-fluoro-1,8-naphthyridine derivative Download PDF

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Publication number
KR830003481A
KR830003481A KR1019800003708A KR800003708A KR830003481A KR 830003481 A KR830003481 A KR 830003481A KR 1019800003708 A KR1019800003708 A KR 1019800003708A KR 800003708 A KR800003708 A KR 800003708A KR 830003481 A KR830003481 A KR 830003481A
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KR
South Korea
Prior art keywords
compound
general formula
product
formula
hydrogen atom
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KR1019800003708A
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Korean (ko)
Inventor
쥰이찌 마쓰모또
유시유끼 다까세
히로유끼 미야모또
Original Assignee
미야다께 도꾸지로
다이닛뽕 세이야꾸 가부시끼 가이샤
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Application filed by 미야다께 도꾸지로, 다이닛뽕 세이야꾸 가부시끼 가이샤 filed Critical 미야다께 도꾸지로
Priority to KR1019800003708A priority Critical patent/KR830003481A/en
Publication of KR830003481A publication Critical patent/KR830003481A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

내용 없음No content

Description

6-플루오로-1,8-나프티리딘 유도체의 제조방법.Process for the preparation of 6-fluoro-1,8-naphthyridine derivatives.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (9)

하기 일반식(Ⅱ)로 표시되는 1,8-나프티리딘 유도체를 산화하여 R1이 보호기인 경우에 반응 생성물을 가수분해 하고 필요에 따라서 생성물을 이의 약학적으로 무해한 염으로 전화시킴을 특징으로 하는 하기 일반식(Ⅰ)로 표시되는 6-플루오로-1,8-나프티리딘 유도체 및 이의 약학적으로 무해한 염의 제조방법.Characterized by oxidizing the 1,8-naphthyridine derivative represented by the following general formula (II) to hydrolyze the reaction product when R 1 is a protecting group and to convert the product to its pharmaceutically harmless salt, if necessary 6-fluoro-1,8-naphthyridine derivative represented by the following general formula (I) and a method for preparing a pharmaceutically harmless salt thereof. (상기식중에서 R1은 수소원자 또는 보호기를 나타내고, R2는 수소원자 또는 1내지 4개의 탄소원자를 갖는 저급알킬기를 나타낸다.)(In the formula, R 1 represents a hydrogen atom or a protecting group, and R 2 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms.) 일반식(Ⅱ)에 있어서 R2가 저급알킬기인 화합물을 산화시킴을 특징으로하는 특허청구의 범위 제1항 기재의 방법.The method according to claim 1, which oxidizes a compound in which R 2 is a lower alkyl group in general formula (II). 일반식(Ⅱ)에 있어서 R1이 보호기이고, R2가 저급알킬기인 화합물을 산화시킴을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.The method according to claim 1 , wherein the compound of formula (II) oxidizes a compound in which R 1 is a protecting group and R 2 is a lower alkyl group. 일반식(Ⅱ)에 있어서 R1이 아세틸기이고, R2가 메틸기인 화합물을 산화시켜 얻어지는 산화생성물을 가수분해하고, 필요에 따라서, 생성물을 산으로 반응시켜 이의 산부가염을 형성함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.In general formula (II), the oxidation product obtained by oxidizing the compound whose R <1> is an acetyl group and R <2> is a methyl group is hydrolyzed, and if necessary, the product is reacted with an acid to form an acid addition salt thereof. The method as described in claim 1 to claim. 일반식(Ⅱ)에 있어서 R2가 수소원자인 화합물을 산화시킴을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.The method according to claim 1, which oxidizes a compound in which R 2 is a hydrogen atom in formula (II). 일반식(Ⅱ)에 있어서 R1이 보호기이고, R2가 수소원자인 화합물을 산화시켜 얻어지는 산화 생성물을 가수분해하여 보호기 R1을 제거시킴을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.The method according to claim 1 , wherein in the general formula (II), R 1 is a protecting group and R 2 is a hydrogen atom, and the protecting product R 1 is removed by hydrolysis of an oxidation product obtained by oxidizing a compound. . 일반식(Ⅱ)의 화합물을 하이포할로게나이트를 사용하여 산화반응을 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.The method according to claim 1, wherein the compound of general formula (II) is oxidized using hypohalogenite. 일반식(Ⅱ)의 화합물에 피리딘과 요오드와의 혼합물을 작용시켜 산화반응을 수행하고 생성물을 알카리로 처리함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.Method according to claim 1, characterized in that a reaction of pyridine with iodine is carried out on a compound of formula (II) to effect oxidation and to treat the product with alkali. 화합물(Ⅱ)의 산화반응을 산화은을 사용하여 수행함을 특징으로 하는 특허청구의 범의 제1항 기재의 방법.The method according to claim 1, wherein the oxidation of compound (II) is carried out using silver oxide. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800003708A 1980-09-22 1980-09-22 Method for preparing 6-fluoro-1,8-naphthyridine derivative KR830003481A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019800003708A KR830003481A (en) 1980-09-22 1980-09-22 Method for preparing 6-fluoro-1,8-naphthyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019800003708A KR830003481A (en) 1980-09-22 1980-09-22 Method for preparing 6-fluoro-1,8-naphthyridine derivative

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KR830003481A true KR830003481A (en) 1983-06-20

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KR1019800003708A KR830003481A (en) 1980-09-22 1980-09-22 Method for preparing 6-fluoro-1,8-naphthyridine derivative

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450317B1 (en) * 1999-08-27 2004-09-30 르 라보레또레 쎄르비에르 New pyridine compounds, a process for their preparation and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450317B1 (en) * 1999-08-27 2004-09-30 르 라보레또레 쎄르비에르 New pyridine compounds, a process for their preparation and pharmaceutical compositions containing them

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