KR920021552A - 라파마이신 대사산물 - Google Patents
라파마이신 대사산물 Download PDFInfo
- Publication number
- KR920021552A KR920021552A KR1019920008034A KR920008034A KR920021552A KR 920021552 A KR920021552 A KR 920021552A KR 1019920008034 A KR1019920008034 A KR 1019920008034A KR 920008034 A KR920008034 A KR 920008034A KR 920021552 A KR920021552 A KR 920021552A
- Authority
- KR
- South Korea
- Prior art keywords
- mass
- rapamycin
- charge ratio
- ions
- characteristic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하전비 899에 대한 질량으로 추적되는 탈양성자화된 분자 이온을 갖고, 하전비 591,569,559,543,529,421 및 308에 대한 질량으로 추적되는 이온을 포함하는 특징적인 화합적 흡착 이온화 질량 분광 분열 패턴을 갖는 라파마이신의 대사산물.
- 41-O-데스메틸 라파마이신인 제1항의 화합물.
- 하전비 928에 대한 질량으로 추적되는 탈양성자화된 분자이온을 갖고, 하전비 607,571,545,513,322,290 및 241에 대한 질량으로 추적되는 이온을 포함하는 특징적인 화학적 흡착이온화 질량분광 분열 패턴을 갖는 라파마이신의 하이드록실화 대사산물.
- 하전비 899에 대한 질량으로 추적되는 탈양성자화된 분자 이온을 갖고, 하전비 591,569,559,543,529,421 및 308에 대한 질량으로 추적되는 이온을 포함하는 특징적인 화합적 흡착 이온화 질량 분광 분열 패턴을 갖는 라파마이신의 대사산물의 유효량을 투여함을 포함하여, 이를 필요로 하는 포유동물에서의 이식 거부, 호스트 대식피 질병, 자동면역 질병 및 염증 질병을 치료하는 방법.
- 41-O-데스메틸 라파마이신인 제1항의 화합물의 유효량을 투여함을 포함하여, 이를 필요로 하는 포유동물에서의 이식 거부, 호스트 대 식피 질병, 자동면역 질병 및 염증 질병을 치료하는 방법.※ 참고사항:최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/699,505 US5776943A (en) | 1991-05-14 | 1991-05-14 | Rapamycin metabolites |
US07/699,505 | 1991-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920021552A true KR920021552A (ko) | 1992-12-18 |
Family
ID=24809620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920008034A KR920021552A (ko) | 1991-05-14 | 1992-05-13 | 라파마이신 대사산물 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5776943A (ko) |
EP (1) | EP0514144B1 (ko) |
JP (1) | JP3183554B2 (ko) |
KR (1) | KR920021552A (ko) |
AT (1) | ATE174918T1 (ko) |
AU (1) | AU659452B2 (ko) |
CA (1) | CA2068349C (ko) |
DE (1) | DE69227942T2 (ko) |
DK (1) | DK0514144T3 (ko) |
ES (1) | ES2126586T3 (ko) |
GR (1) | GR3029767T3 (ko) |
HK (1) | HK1010369A1 (ko) |
IE (1) | IE921525A1 (ko) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9302569D0 (en) * | 1993-02-10 | 1993-03-24 | Smithkline Beecham Plc | Novel compound |
GB9315914D0 (en) * | 1993-07-31 | 1993-09-15 | Smithkline Beecham Plc | Novel compound |
WO1996006847A1 (en) * | 1994-08-31 | 1996-03-07 | Pfizer Inc. | Process for preparing demethylrapamycins |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
IT1289815B1 (it) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
ATE420160T1 (de) * | 2003-06-18 | 2009-01-15 | Genelux Corp | Modifizierte rekombinante vacciniaviren, verwendungen davon |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US4981792A (en) * | 1988-06-29 | 1991-01-01 | Merck & Co., Inc. | Immunosuppressant compound |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
EP0413532A3 (en) * | 1989-08-18 | 1991-05-15 | Fisons Plc | Macrocyclic compounds |
US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
US5023262A (en) * | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
FI921595A (fi) * | 1991-04-17 | 1992-10-18 | American Home Prod | Rapamycinkarbamater |
US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
FI97472C (fi) * | 1991-05-07 | 1996-12-27 | American Home Prod | Menetelmä terapeuttisesti käyttökelpoisten rapamysiinijohdannaisten valmistamiseksi anti-inflammatorisina ja antifungaalisina aineina |
US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
-
1991
- 1991-05-14 US US07/699,505 patent/US5776943A/en not_active Expired - Lifetime
-
1992
- 1992-05-11 CA CA002068349A patent/CA2068349C/en not_active Expired - Fee Related
- 1992-05-11 AU AU16154/92A patent/AU659452B2/en not_active Ceased
- 1992-05-12 JP JP11881192A patent/JP3183554B2/ja not_active Expired - Fee Related
- 1992-05-13 AT AT92304293T patent/ATE174918T1/de not_active IP Right Cessation
- 1992-05-13 EP EP92304293A patent/EP0514144B1/en not_active Expired - Lifetime
- 1992-05-13 KR KR1019920008034A patent/KR920021552A/ko not_active Application Discontinuation
- 1992-05-13 DE DE69227942T patent/DE69227942T2/de not_active Expired - Fee Related
- 1992-05-13 ES ES92304293T patent/ES2126586T3/es not_active Expired - Lifetime
- 1992-05-13 DK DK92304293T patent/DK0514144T3/da active
- 1992-07-01 IE IE152592A patent/IE921525A1/en not_active IP Right Cessation
-
1998
- 1998-09-25 HK HK98110983A patent/HK1010369A1/xx not_active IP Right Cessation
-
1999
- 1999-03-22 GR GR990400854T patent/GR3029767T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE174918T1 (de) | 1999-01-15 |
DE69227942D1 (de) | 1999-02-04 |
CA2068349A1 (en) | 1992-11-15 |
DE69227942T2 (de) | 1999-08-26 |
EP0514144A2 (en) | 1992-11-19 |
HK1010369A1 (en) | 1999-06-17 |
EP0514144A3 (en) | 1993-03-03 |
ES2126586T3 (es) | 1999-04-01 |
EP0514144B1 (en) | 1998-12-23 |
IE921525A1 (en) | 1992-11-18 |
AU1615492A (en) | 1992-11-19 |
US5776943A (en) | 1998-07-07 |
JP3183554B2 (ja) | 2001-07-09 |
CA2068349C (en) | 2002-04-09 |
JPH05130884A (ja) | 1993-05-28 |
GR3029767T3 (en) | 1999-06-30 |
DK0514144T3 (da) | 1999-08-23 |
AU659452B2 (en) | 1995-05-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |